ES8609253A1 - Un procedimiento para la preparacion de derivados de dihi- dropiridina - Google Patents

Un procedimiento para la preparacion de derivados de dihi- dropiridina

Info

Publication number
ES8609253A1
ES8609253A1 ES544558A ES544558A ES8609253A1 ES 8609253 A1 ES8609253 A1 ES 8609253A1 ES 544558 A ES544558 A ES 544558A ES 544558 A ES544558 A ES 544558A ES 8609253 A1 ES8609253 A1 ES 8609253A1
Authority
ES
Spain
Prior art keywords
intermediates
processes
preparation
dihydropyridine derivatives
pharmaceutical preparations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES544558A
Other languages
English (en)
Other versions
ES544558A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES8609253A1 publication Critical patent/ES8609253A1/es
Publication of ES544558A0 publication Critical patent/ES544558A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Dental Preparations (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE DIHIDROPIRIDINA DE FORMULA GENERAL (I) EN DONDE A ES EL GRUPO -CH(R7)-CO- SIENDO R ARILO O UN RADICAL HETEROCICLICO, T1 HIDROGENO O METILO, R2 HIDROGENO O UN ALQUILO DE C1 A C4 Y R3, R4, R5, R6 Y R7 DIFERENTES GRUPOS ALQUILO DISTINTAMENTE SUSTITUIDOS. COMPRENDE LA REACCION DE UNA ENAMINA DE FORMULA GENERAL (II) EN DONDE R1, R2, R5, R6 Y R7 TIENEN EL SIGNIFICADO ANTES INDICADO, CON UN COMPUESTO ILIDENICO DE FORMULA GENERAL (III), EN PRESENCIA DE UN DISOLVENTE INERTE O UNA MEZCLA DISOLVENTE, A TEMPERATURA ENTRE 20 Y 150JC. APLICABLES POR SU ACTIVIDAD CALCIO-ANTAGONISTICA PARA EL CONTROL O PREVENCION DE ANGINA DE PECHO, ISQUEMIA, HIPERTENSION Y MIGRAÑA.
ES544558A 1984-06-27 1985-06-26 Un procedimiento para la preparacion de derivados de dihi- dropiridina Expired ES8609253A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH309784 1984-06-27

Publications (2)

Publication Number Publication Date
ES8609253A1 true ES8609253A1 (es) 1986-09-01
ES544558A0 ES544558A0 (es) 1986-09-01

Family

ID=4248551

Family Applications (2)

Application Number Title Priority Date Filing Date
ES544558A Expired ES8609253A1 (es) 1984-06-27 1985-06-26 Un procedimiento para la preparacion de derivados de dihi- dropiridina
ES551817A Expired ES8705388A1 (es) 1984-06-27 1986-01-31 Un procedimiento para la preparacion de derivados de dihidropiridina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES551817A Expired ES8705388A1 (es) 1984-06-27 1986-01-31 Un procedimiento para la preparacion de derivados de dihidropiridina

Country Status (16)

Country Link
US (1) US4742069A (es)
EP (1) EP0166422A1 (es)
JP (1) JPS6118762A (es)
CN (1) CN85105335A (es)
AU (1) AU4399185A (es)
DK (1) DK288085A (es)
ES (2) ES8609253A1 (es)
FI (1) FI852359L (es)
GR (1) GR851554B (es)
HU (1) HU193784B (es)
IL (1) IL75595A0 (es)
MC (1) MC1675A1 (es)
NO (1) NO852576L (es)
PH (1) PH21510A (es)
PT (1) PT80719B (es)
ZA (1) ZA854665B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6541479B1 (en) 1997-12-02 2003-04-01 Massachusetts College Of Pharmacy Calcium channel blockers
CN106011652B (zh) 2016-06-28 2017-12-26 宝山钢铁股份有限公司 一种磷化性能优异的冷轧低密度钢板及其制造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2639498A1 (de) * 1976-09-02 1978-03-09 Bayer Ag Neue schwefelhaltige amino-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2658183A1 (de) * 1976-12-22 1978-07-06 Bayer Ag In 2-position substituierte 1,4- dihydropyridin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2747513A1 (de) * 1977-10-22 1979-05-03 Bayer Ag Dihydropyridine mit schwefelhaltigen estergruppierungen
SE429652B (sv) * 1978-06-30 1983-09-19 Haessle Ab 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester
DE3116129A1 (de) * 1981-04-23 1982-11-11 Hoechst Ag, 6000 Frankfurt 2-ketosulfonamide und verfahren zu ihrer herstellung
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines

Also Published As

Publication number Publication date
FI852359A0 (fi) 1985-06-13
DK288085D0 (da) 1985-06-25
GR851554B (es) 1985-11-25
US4742069A (en) 1988-05-03
ES551817A0 (es) 1987-05-01
HUT37923A (en) 1986-03-28
PH21510A (en) 1987-11-10
JPS6118762A (ja) 1986-01-27
DK288085A (da) 1985-12-28
NO852576L (no) 1985-12-30
ZA854665B (en) 1986-02-26
PT80719B (en) 1987-04-23
ES8705388A1 (es) 1987-05-01
HU193784B (en) 1987-11-30
CN85105335A (zh) 1987-01-14
FI852359L (fi) 1985-12-28
IL75595A0 (en) 1985-10-31
AU4399185A (en) 1986-01-02
MC1675A1 (fr) 1986-06-03
EP0166422A1 (de) 1986-01-02
PT80719A (en) 1985-07-01
ES544558A0 (es) 1986-09-01

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