ES8609343A1 - Un metodo para preparar un derivado de cefem - Google Patents

Un metodo para preparar un derivado de cefem

Info

Publication number
ES8609343A1
ES8609343A1 ES543932A ES543932A ES8609343A1 ES 8609343 A1 ES8609343 A1 ES 8609343A1 ES 543932 A ES543932 A ES 543932A ES 543932 A ES543932 A ES 543932A ES 8609343 A1 ES8609343 A1 ES 8609343A1
Authority
ES
Spain
Prior art keywords
group
stands
hydrogen atom
pyrazolo
pyridinium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES543932A
Other languages
English (en)
Other versions
ES543932A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP1984/000295 external-priority patent/WO1986000070A1/ja
Priority claimed from PCT/JP1985/000155 external-priority patent/WO1986005787A1/ja
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of ES543932A0 publication Critical patent/ES543932A0/es
Publication of ES8609343A1 publication Critical patent/ES8609343A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

METODO PARA PRODUCIR DERIVADOS DE CEFEM. CONSISTE EN HACER REACCIONAR A UN COMPUESTO DE FORMULA (II) CON UN PIRAZOL OPCIONALMENTE SUSTITUIDO QUE FORMA UN ANILLO CONDENSADO EN LA POSICION 1,5, PARA FORMAR UN COMPUESTO DE FORMULA (I), SUS SALES O ESTERES FISIOLOGICAMENTE O FARMACEUTICAMENTE ACEPTABLES. SIENDO: A, UN GRUPO PIRAZOL-2-ILO OPCIONALMENTE SUSTITUIDO QUE FORMA UN ANILLO CONDENSADO EN LA POSICION 1,5; R0, H; R4, H, UN GRUPO METOXI O UN GRUPO FORMAMIDO; R5, UN GRUPO HIDROXILO, UN GRUPO ALCOXI, UN GRUPO CARBAMOILOXI Y OTROS; R13, H, UN GRUPO METILO O UN GRUPO HIDROXILO; Y Z, S, S 9 O, O O CH2. SE UTILIZAN COMO AGENTES ANTIBACTERIANOS CONTRA BACTERIAS GRAM-POSITIVAS (STAPHYLOCOCCUS AUREUS O CORYNEBACTERIUM DIPHTHERIAE) Y GRAM-NEGATIVAS PRODUCTORAS DE B-LACTAMASAS DE GENEROS (ESCHERICHIA, ENTEROBACTER O SERRATIA).43
ES543932A 1984-06-07 1985-06-05 Un metodo para preparar un derivado de cefem Expired ES8609343A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/JP1984/000295 WO1986000070A1 (en) 1984-06-07 1984-06-07 Cephem compounds
PCT/JP1985/000155 WO1986005787A1 (en) 1985-04-01 1985-04-01 Antibacterial compounds

Publications (2)

Publication Number Publication Date
ES543932A0 ES543932A0 (es) 1986-08-16
ES8609343A1 true ES8609343A1 (es) 1986-08-16

Family

ID=26425045

Family Applications (2)

Application Number Title Priority Date Filing Date
ES543932A Expired ES8609343A1 (es) 1984-06-07 1985-06-05 Un metodo para preparar un derivado de cefem
ES551064A Expired ES8800240A1 (es) 1984-06-07 1986-01-21 Un metodo para preparar derivados de cefem

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES551064A Expired ES8800240A1 (es) 1984-06-07 1986-01-21 Un metodo para preparar derivados de cefem

Country Status (15)

Country Link
US (1) US4665065A (es)
EP (1) EP0164113B1 (es)
KR (1) KR920004823B1 (es)
AU (1) AU576588B2 (es)
CA (1) CA1264052A (es)
DE (1) DE3577707D1 (es)
DK (1) DK256085A (es)
ES (2) ES8609343A1 (es)
FI (1) FI852289L (es)
GR (1) GR851384B (es)
HU (1) HU194894B (es)
NO (1) NO852294L (es)
NZ (1) NZ212320A (es)
PH (1) PH22107A (es)
PT (1) PT80595B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4788185A (en) * 1984-04-23 1988-11-29 Takeda Chemical Industries, Ltd. Cephalosporin compounds
EP0203271B1 (en) * 1985-03-01 1993-05-26 Takeda Chemical Industries, Ltd. Antibacterial compounds, their production and use
ATE89826T1 (de) * 1985-03-01 1993-06-15 Takeda Chemical Industries Ltd Antibakterielle verbindungen, ihre herstellung und verwendung.
ATE82976T1 (de) * 1985-09-03 1992-12-15 Otsuka Kagaku Kk Cephalosporinderivate.
US4826834A (en) * 1985-09-27 1989-05-02 Takeda Chemical Industries, Ltd. Cephem compounds
US4760140A (en) * 1986-10-20 1988-07-26 American Cyanamid Company 3-substituted-7-[5-substituted-2-thiazolyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic acid, diphenylmethyl esters
CA1293719C (en) * 1986-09-22 1991-12-31 Takao Takaya Cephem compounds and processes for preparation thereof
US5019571A (en) * 1988-01-25 1991-05-28 Eli Lilly And Company 1-carbacephalosporin antibiotics
DE3803169A1 (de) * 1988-02-03 1989-08-17 Bayer Ag Ss-lactam-antibiotika, verfahren zu ihrer herstellung und ihre verwendung als und in arzneimitteln
GB8805642D0 (en) * 1988-03-09 1988-04-07 Fujisawa Pharmaceutical Co New cephem compounds & processes for preparation thereof
US5173485A (en) * 1988-03-09 1992-12-22 Fujisawa Pharmaceutical Company, Ltd. Cephem compounds
US5215982A (en) * 1989-11-10 1993-06-01 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
KR930009796B1 (ko) * 1991-05-25 1993-10-11 주식회사 대웅제약 신규의 세팔로스포린 및 그의 제조방법
CA2258965A1 (en) * 1996-06-28 1998-01-08 Oxigene, Inc. Useful formulations of acid addition salt drugs

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4024133A (en) * 1971-05-14 1977-05-17 Glaxo Laboratories Limited 7β-[2-Etherified oximino-2-(thienyl-,furyl- or pyridylacetamido)]cephalosporins
US4033950A (en) * 1971-05-14 1977-07-05 Glaxo Laboratories Limited 3-Hydroxymethyl-7β-(2-alkoxy-or benzyloxyimino-2-arylacetamido)ceph-3-em-4-carboxylic acids and salts thereof
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
GR63088B (en) * 1976-04-14 1979-08-09 Takeda Chemical Industries Ltd Preparation process of novel cephalosporins
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
AR228726A1 (es) * 1978-05-26 1983-04-15 Glaxo Group Ltd Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato
GB2037281B (en) * 1978-11-15 1983-01-19 Glaxo Group Ltd 7( -(2-amino-4-thiozolyl)-2-hydroximino-acetanuds)-cephalosporins
ES8306160A1 (es) * 1981-04-03 1983-05-01 Fujisawa Pharmaceutical Co "procedimiento para preparar un nuevo compuesto de cefem".
US4501739A (en) * 1982-01-19 1985-02-26 Eli Lilly And Company Thieno and furopyridinium-substituted cephalosporins
US4500526A (en) * 1982-06-28 1985-02-19 Bristol-Myers Company Cephalosporin derivatives
DE3336757A1 (de) * 1983-10-08 1985-04-25 Hoechst Ag, 6230 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
EP0138552A3 (en) * 1983-10-17 1986-03-19 Eli Lilly And Company Improvements on or relating to 3-bicyclicpyridinium-methyl cephalosporins
GB8401093D0 (en) * 1984-01-16 1984-02-15 Fujisawa Pharmaceutical Co Cephem compounds
NO165842C (no) * 1984-04-23 1991-04-17 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive cefem-forbindelser.

Also Published As

Publication number Publication date
ES8800240A1 (es) 1987-11-01
EP0164113A3 (en) 1987-01-28
DE3577707D1 (de) 1990-06-21
EP0164113A2 (en) 1985-12-11
HUT41034A (en) 1987-03-30
AU576588B2 (en) 1988-09-01
PT80595A (en) 1985-07-01
ES543932A0 (es) 1986-08-16
KR860000302A (ko) 1986-01-27
FI852289A0 (fi) 1985-06-07
PH22107A (en) 1988-06-01
ES551064A0 (es) 1987-11-01
PT80595B (en) 1987-04-21
DK256085A (da) 1985-12-08
EP0164113B1 (en) 1990-05-16
NZ212320A (en) 1988-09-29
HU194894B (en) 1988-03-28
DK256085D0 (da) 1985-06-06
US4665065A (en) 1987-05-12
FI852289L (fi) 1985-12-08
GR851384B (es) 1985-11-25
KR920004823B1 (ko) 1992-06-18
AU4330685A (en) 1985-12-12
CA1264052A (en) 1989-12-27
NO852294L (no) 1985-12-09

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