JPS57114591A - Preparation of cephalosporin derivative - Google Patents
Preparation of cephalosporin derivativeInfo
- Publication number
- JPS57114591A JPS57114591A JP10004481A JP10004481A JPS57114591A JP S57114591 A JPS57114591 A JP S57114591A JP 10004481 A JP10004481 A JP 10004481A JP 10004481 A JP10004481 A JP 10004481A JP S57114591 A JPS57114591 A JP S57114591A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- lower alkyl
- infectious diseases
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The cephalosporin derivative of formulaI[R1 is H or lower alkyl; X is O, S, or NR2 (R2 is H, lower alkyl, etc.); Y is H, lower acyloxy, or SR3 (R3 is nitrogen-containing 5-membered heterocyclic group which may have lower alkyl substituent group and may contain O or S)].
EXAMPLE: 7-[2-(2-Aminothiaxol-4-yl)acetamido]-3-(1,3,4-thiadiazol-2-yl)thiomethyl- 3-cephem-4-carboxylic acid sodium salt.
USE: Antimicrobial agent effective to respiratory infectious diseases, purulent diseases, infectious diseases of the urinary tract, puerperal infectious diseases, etc. Does: 5W20mg/kg daily by parenteral administration divided in 3W4 doses.
PROCESS: The compound of formulaIis prepared by the dehydrative cyclization reaction of a novel compound of formula II in a solvent in the presence of an acid or a base. The starting compound of formula II can be prepared by reacting a novel compound of formula III (w is halogen) with a compound of formula IV.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10004481A JPS5831356B2 (en) | 1981-06-26 | 1981-06-26 | Method for producing cephalosporin derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10004481A JPS5831356B2 (en) | 1981-06-26 | 1981-06-26 | Method for producing cephalosporin derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11620481A Division JPS5831357B2 (en) | 1981-07-23 | 1981-07-23 | Method for producing cephalosporin derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57114591A true JPS57114591A (en) | 1982-07-16 |
| JPS5831356B2 JPS5831356B2 (en) | 1983-07-05 |
Family
ID=14263504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10004481A Expired JPS5831356B2 (en) | 1981-06-26 | 1981-06-26 | Method for producing cephalosporin derivatives |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5831356B2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107987091A (en) * | 2017-11-07 | 2018-05-04 | 河北九派制药股份有限公司 | A kind of preparation method of cefotiam hydrochloride impurity 3- methyl cefotiam chlorides |
-
1981
- 1981-06-26 JP JP10004481A patent/JPS5831356B2/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107987091A (en) * | 2017-11-07 | 2018-05-04 | 河北九派制药股份有限公司 | A kind of preparation method of cefotiam hydrochloride impurity 3- methyl cefotiam chlorides |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5831356B2 (en) | 1983-07-05 |
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