ES8702364A1 - Procedimiento para preparar nuevos derivados de benzazepinas. - Google Patents

Procedimiento para preparar nuevos derivados de benzazepinas.

Info

Publication number
ES8702364A1
ES8702364A1 ES551788A ES551788A ES8702364A1 ES 8702364 A1 ES8702364 A1 ES 8702364A1 ES 551788 A ES551788 A ES 551788A ES 551788 A ES551788 A ES 551788A ES 8702364 A1 ES8702364 A1 ES 8702364A1
Authority
ES
Spain
Prior art keywords
alkoxy
alkyl
hydrogen
bromine
benzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES551788A
Other languages
English (en)
Other versions
ES551788A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES551788A0 publication Critical patent/ES551788A0/es
Publication of ES8702364A1 publication Critical patent/ES8702364A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C07D233/08—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms with alkyl radicals, containing more than four carbon atoms, directly attached to ring carbon atoms
    • C07D233/12—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms with alkyl radicals, containing more than four carbon atoms, directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D233/16—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE DERIVADOS DE BENZAZEPINA DE FORMULA (I), DONDE A ES -CH2-CH2- O -CHFCH-, R1 ES H, CL, BR O ALQUILO, AMINO, ALQUILAMINO, DIALQUILAMINO, ACILAMINO, HIDROXI, ALCOXI O FENILALCOXI, CON FRACCIONES ALQUILO C1-C3; R2 ES H, CL, BR, HIDROXI, ALQUILO, ALCOXI O FENILALCOXI CON FRACCIONES ALQUILO C1-C3 O R1 Y R2 SON UN ALQUILENDIOXI; R3 ES H, CL, BR O ALCOXI C1-C3; R4 ES ALQUILO C1-C3; R5 ES H, HALOGENO, ALQUILO O ALCOXI C1-C3; R6 ES H, ALQUILO O ALCOXI C1-C3, O R5 Y R6 SON ALQUILENDIOXI; X ES IMINO, SUSTITUIDO O NO O O, S, SULFINILO O SULFONILO; Y ES IMINO SUSTITUIDO O NO, ALQUILO C1-C3, METILENO O CARBONILO; N ES 2, 3 O 4 Y M ES 2, 3 O 4, Y DE SUS SALES. SE OBTIENEN A PARTIR DE (II), DONDE TODOS LOS GRUPOS SE HAN DEFINIDO, MENOR RK1 QUE ES UN HIDROXIAMINO O ALQUILAMINO PROTEGIDO O ES R1; RK4 ES H O R4, XK ES IMINO O X, CON UN COMPUESTO R7-CHO, SIENDO R7 H, METILO O ETILO, EN PRESENCIA DE UN REDUCTOR. SON REDUCTORES DEL RITMO CARDIACO O A-BLOQUEANTES.
ES551788A 1984-05-17 1986-02-10 Procedimiento para preparar nuevos derivados de benzazepinas. Expired ES8702364A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843418271 DE3418271A1 (de) 1984-05-17 1984-05-17 Neue benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
ES551788A0 ES551788A0 (es) 1986-12-16
ES8702364A1 true ES8702364A1 (es) 1986-12-16

Family

ID=6236071

Family Applications (3)

Application Number Title Priority Date Filing Date
ES543188A Expired ES8607248A1 (es) 1984-05-17 1985-05-16 Procedimiento para preparar nuevos derivados de benzazepina
ES551789A Expired ES8702365A1 (es) 1984-05-17 1986-02-10 Procedimiento para preparar nuevos derivados de benzazepina.
ES551788A Expired ES8702364A1 (es) 1984-05-17 1986-02-10 Procedimiento para preparar nuevos derivados de benzazepinas.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES543188A Expired ES8607248A1 (es) 1984-05-17 1985-05-16 Procedimiento para preparar nuevos derivados de benzazepina
ES551789A Expired ES8702365A1 (es) 1984-05-17 1986-02-10 Procedimiento para preparar nuevos derivados de benzazepina.

Country Status (17)

Country Link
US (1) US4604389A (es)
EP (1) EP0161599A3 (es)
JP (1) JPS60255770A (es)
KR (1) KR850008667A (es)
AU (1) AU572998B2 (es)
CA (1) CA1247612A (es)
DE (1) DE3418271A1 (es)
DK (1) DK206785A (es)
ES (3) ES8607248A1 (es)
FI (1) FI851924L (es)
GR (1) GR851151B (es)
IL (1) IL75219A (es)
NO (1) NO851950L (es)
NZ (1) NZ212103A (es)
PH (1) PH20762A (es)
PT (1) PT80484B (es)
ZA (1) ZA853667B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3418270A1 (de) * 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3717561A1 (de) * 1987-05-25 1988-12-08 Thomae Gmbh Dr K Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5175157A (en) * 1985-11-27 1992-12-29 Boehringer Ingelheim Gmbh Cyclic amine derivatives, pharmaceutical compositions containing these compounds and methods for preparing them
DE3541811A1 (de) * 1985-11-27 1987-06-04 Thomae Gmbh Dr K Neue cyclische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3631013A1 (de) * 1986-09-12 1988-03-24 Thomae Gmbh Dr K Neue naphthylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
AU666318B2 (en) * 1991-06-28 1996-02-08 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
US5939412A (en) * 1992-06-26 1999-08-17 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
GB9321812D0 (en) * 1993-10-22 1993-12-15 Smithkline Beecham Plc Pharmaceuticals
MA23420A1 (fr) * 1994-01-07 1995-10-01 Smithkline Beecham Corp Antagonistes bicycliques de fibrinogene.
US6458784B1 (en) 1994-06-29 2002-10-01 Smithkline Beecham Corporation Vitronectin receptor antagonists
US5977101A (en) * 1995-06-29 1999-11-02 Smithkline Beecham Corporation Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity
US20030125317A1 (en) * 1996-10-02 2003-07-03 Smithkline Beecham Corporation Vitronectin receptor antagonists
CA2537124C (en) * 2003-08-29 2012-08-07 Mitsui Chemicals, Inc. Agricultural/horticultural insecticide and method for using the same
FR2932800B1 (fr) * 2008-06-20 2015-02-20 Servier Lab Nouveau procede de synthese de la 7,8-dimethoxy-1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
EP2495237A1 (en) * 2011-03-04 2012-09-05 Alembic Pharmaceuticals Limited An improved process for the preparation of highly pure ivabradine hydrochloride

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4131685A (en) * 1972-12-15 1978-12-26 Imperial Chemical Industries Limited Pharmaceutical compositions and uses of alkanolamine derivatives
DE3242599A1 (de) * 1982-11-18 1984-05-24 Dr. Karl Thomae Gmbh, 7950 Biberach Neue benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel
DE3119874A1 (de) * 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
US4490369A (en) * 1981-05-19 1984-12-25 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Benzazepine derivatives, their pharmaceutical compositions and method of use

Also Published As

Publication number Publication date
EP0161599A3 (de) 1986-10-08
ES551788A0 (es) 1986-12-16
ES551789A0 (es) 1986-12-16
ES8607248A1 (es) 1986-05-16
KR850008667A (ko) 1985-12-21
FI851924A0 (fi) 1985-05-15
CA1247612A (en) 1988-12-28
PT80484A (de) 1985-06-01
DK206785D0 (da) 1985-05-09
EP0161599A2 (de) 1985-11-21
PT80484B (de) 1987-04-21
DK206785A (da) 1985-11-18
ES543188A0 (es) 1986-05-16
NO851950L (no) 1985-11-18
PH20762A (en) 1987-04-10
ES8702365A1 (es) 1986-12-16
AU4268285A (en) 1985-11-21
JPS60255770A (ja) 1985-12-17
ZA853667B (en) 1987-01-28
US4604389A (en) 1986-08-05
DE3418271A1 (de) 1985-11-21
NZ212103A (en) 1988-10-28
AU572998B2 (en) 1988-05-26
GR851151B (es) 1985-11-25
IL75219A (en) 1989-02-28
FI851924L (fi) 1985-11-18
IL75219A0 (en) 1985-09-29

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