ES8608523A1 - Procedimiento de producir alquilangelicinas - Google Patents

Procedimiento de producir alquilangelicinas

Info

Publication number
ES8608523A1
ES8608523A1 ES526910A ES526910A ES8608523A1 ES 8608523 A1 ES8608523 A1 ES 8608523A1 ES 526910 A ES526910 A ES 526910A ES 526910 A ES526910 A ES 526910A ES 8608523 A1 ES8608523 A1 ES 8608523A1
Authority
ES
Spain
Prior art keywords
photochemotherapic
methylangelicin
compounds
treating psoriasis
alkylangelicins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES526910A
Other languages
English (en)
Other versions
ES526910A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consiglio Nazionale delle Richerche CNR
Original Assignee
Consiglio Nazionale delle Richerche CNR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consiglio Nazionale delle Richerche CNR filed Critical Consiglio Nazionale delle Richerche CNR
Publication of ES526910A0 publication Critical patent/ES526910A0/es
Publication of ES8608523A1 publication Critical patent/ES8608523A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ALQUILANGELICINAS, LIBRES DE PSORALENOS, Y DE SUS SALES, DE FORMULA (I), EN LA QUE R, R1, R2, R3 Y R5 REPRESENTAN ALQUILO Y R6 PUEDE SER UNO DE VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE TRANSPOSICION DEL GRUPO R4 EN UN COMPUESTO DE FORMULA (II), EN LA QUE R4 ES UN RESIDUO DE ACILO O DE ALILO Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), EN LAS CONDICIONES DE LA REACCION DE FRIES O CLAISEN, BAJO FUSION EN PRESENCIA DE TRICLORURO DE ALUMINIO O EN DIETILANILINA HIRVIENTE; SEGUIDA DE LA CICLACION DEL COMPUESTO FORMADO MEDIANTE TRANSFORMACION EN 7-CUMARINILOXIACETATO, HIDROLISIS Y REFLUJO EN ANHIDRIDO ACETICO, EN PRESENCIA DE ACETATO SODICO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA LA FOTOQUIMIOTERAPIA DE PSORIASIS, DEL VITILIGO Y DE LA ALOPECIA AERATA.43
ES526910A 1982-10-18 1983-10-18 Procedimiento de producir alquilangelicinas Expired ES8608523A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT84148/82A IT1165797B (it) 1982-10-18 1982-10-18 Procedimento di preparazione di alchilangelicine esenti da psoraleni ed alchilangolicine ottenute col procedimento

Publications (2)

Publication Number Publication Date
ES526910A0 ES526910A0 (es) 1986-07-16
ES8608523A1 true ES8608523A1 (es) 1986-07-16

Family

ID=11324788

Family Applications (1)

Application Number Title Priority Date Filing Date
ES526910A Expired ES8608523A1 (es) 1982-10-18 1983-10-18 Procedimiento de producir alquilangelicinas

Country Status (12)

Country Link
US (1) US5001147A (es)
JP (1) JPH0633269B2 (es)
AT (1) AT384810B (es)
AU (1) AU559082B2 (es)
CA (1) CA1228860A (es)
CH (1) CH662566A5 (es)
DE (1) DE3337207A1 (es)
ES (1) ES8608523A1 (es)
FR (1) FR2534585B1 (es)
GB (1) GB2128997B (es)
IT (1) IT1165797B (es)
ZA (1) ZA837585B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1242055B1 (en) * 1999-12-23 2008-04-23 Pfizer Products Inc. Hydrogel-driven drug dosage form
JP5230420B2 (ja) * 2005-08-18 2013-07-10 ゲンマブ エー／エス Ｃｄ４結合ペプチドおよび放射線による治療
ITVE20070005A1 (it) 2007-01-25 2008-07-26 Associazione Veneta Per La Lotta Alla Talassemia Farmaco per la cura della talassemia, dell'anemia falciforme e di tutte le altre forme di anemia trattabili con questo, metodo di attivazione del farmaco, composizione farmaceutica avente come principio attivo il farmaco e metodo fotochemioterapico u
CN102177162B (zh) * 2008-10-21 2015-02-11 花王株式会社 Nfat信号抑制剂以及育发剂
CN105832720B (zh) * 2016-05-03 2019-04-05 中国科学院新疆理化技术研究所 一种补骨脂素类化合物的用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI59598C (fi) * 1977-10-03 1981-09-10 Star Oy Ab Nytt foerfarande foer framstaellning av i 9-staellningen eventuellt metoxisubstituerade 7h-furo(3,2-g)(1)bensopyran-7-oner
JPS55124775A (en) * 1979-03-13 1980-09-26 Elder Thomas C Inc Alphaalower alkylfurocoumarin manufacture and intermediate oftained therefrom
US4216154A (en) * 1979-03-15 1980-08-05 Thomas C. Elder, Inc. Process for making α-loweralkylfurocoumarins
IT1166343B (it) * 1979-08-20 1987-04-29 Francarosa Baccichetti Furocumarina per la fotochemioterapia della fsoriasi e di altre malattie cutanee ad essa sensibili

Also Published As

Publication number Publication date
FR2534585B1 (fr) 1986-12-19
CA1228860A (en) 1987-11-03
US5001147A (en) 1991-03-19
GB2128997A (en) 1984-05-10
ATA370383A (de) 1987-06-15
FR2534585A1 (fr) 1984-04-20
JPS59104387A (ja) 1984-06-16
AU559082B2 (en) 1987-02-19
CH662566A5 (it) 1987-10-15
GB8327200D0 (en) 1983-11-09
DE3337207A1 (de) 1984-04-19
AU2014183A (en) 1984-05-03
ES526910A0 (es) 1986-07-16
JPH0633269B2 (ja) 1994-05-02
DE3337207C2 (es) 1991-12-19
AT384810B (de) 1988-01-11
GB2128997B (en) 1985-12-24
IT1165797B (it) 1987-04-29
ZA837585B (en) 1984-06-27
IT8284148A0 (it) 1982-10-18

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20041102