ES8606373A1 - Procedimiento para la preparacion de derivados de esfingosina - Google Patents

Procedimiento para la preparacion de derivados de esfingosina

Info

Publication number
ES8606373A1
ES8606373A1 ES548901A ES548901A ES8606373A1 ES 8606373 A1 ES8606373 A1 ES 8606373A1 ES 548901 A ES548901 A ES 548901A ES 548901 A ES548901 A ES 548901A ES 8606373 A1 ES8606373 A1 ES 8606373A1
Authority
ES
Spain
Prior art keywords
hydroxyl group
diastereomers
eliminating
separation
carried out
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES548901A
Other languages
English (en)
Other versions
ES548901A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ICN Switzerland AG
Original Assignee
Solco Basel AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH6493/83A external-priority patent/CH679209A5/de
Application filed by Solco Basel AG filed Critical Solco Basel AG
Publication of ES548901A0 publication Critical patent/ES548901A0/es
Publication of ES8606373A1 publication Critical patent/ES8606373A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ESFINGOSINA, DE FORMULA (I), EN LA QUE R1 Y R2 PUEDEN SER VARIOS TIPOS DE RADICALES. COMPRENDE LA REACCION DE UN COMPUESTO RACEMICO DE FORMULA (II) O (III), EN LAS QUE R1 Y R2 TIENEN LOS MISMOS SIGNIFICADOS QUE EN LA FORMULA (I), CON UN REACTIVO ORGANICO SELECTIVO DEL GRUPO HIDROXILICO PRIMARIOI, QUE INTRODUZCA EL GRUPO PROTECTOR R; ESTERIFICACION DEL COMPUESTO RESULTANTE CON UN ACIDO CARBOXILICO, OPTICAMENTE ACTIVO Y SEPARAR LOS DIASTEREOMEROS. DESACILACION DEL DIASTEREOMERO D, ESTERIFICACION PARA FORMAR ENANTIOMEROS Y LIBERACION DEL GRUPO R; REACCION DEL COMPUESTO OBTENIDO CON O-TRIFLUORO U O-TRICLORO-ACETAMIDATO DE UNA D-GLUCOSA CON LOS HIDROXILOS 2,3,4 Y 6 PROTEGIDOS; Y SEPARACION DE LOS GRUPOS PROTECTORES. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE HERIDAS O ULCERACIONES DE CURACION DIFICIL O LENTA.
ES548901A 1983-12-05 1985-11-02 Procedimiento para la preparacion de derivados de esfingosina Expired ES8606373A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH6493/83A CH679209A5 (en) 1983-12-05 1983-12-05 New neutral glyco-sphingolipid derivs.
CH467184 1984-09-28

Publications (2)

Publication Number Publication Date
ES548901A0 ES548901A0 (es) 1986-04-16
ES8606373A1 true ES8606373A1 (es) 1986-04-16

Family

ID=25696036

Family Applications (2)

Application Number Title Priority Date Filing Date
ES538231A Expired ES8604986A1 (es) 1983-12-05 1984-12-04 Procedimiento para la preparacion de derivado de esfingosina.
ES548901A Expired ES8606373A1 (es) 1983-12-05 1985-11-02 Procedimiento para la preparacion de derivados de esfingosina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES538231A Expired ES8604986A1 (es) 1983-12-05 1984-12-04 Procedimiento para la preparacion de derivado de esfingosina.

Country Status (11)

Country Link
US (1) US4952683A (es)
EP (1) EP0146810A3 (es)
AU (1) AU570087B2 (es)
CA (1) CA1259610A (es)
DK (1) DK573384A (es)
ES (2) ES8604986A1 (es)
FI (1) FI844775L (es)
HU (1) HU195516B (es)
NO (1) NO844815L (es)
PL (1) PL143901B1 (es)
YU (2) YU202784A (es)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1199116B (it) * 1984-07-03 1988-12-30 Fidia Farmaceutici Derivati di gangliosidi
DK17885D0 (da) * 1985-01-14 1985-01-14 Karlsson Karl Anders Antiviralt middel
EP0212400B1 (de) * 1985-08-13 1992-01-02 Solco Basel AG Neues Verfahren zur Herstellung von Sphingosinderivaten
US4769362A (en) * 1985-10-01 1988-09-06 Trustees Of Boston University Increased vascular perfusion following administration of lipids
JPH07116209B2 (ja) * 1986-04-11 1995-12-13 メクト株式会社 シアロシルセラミド類及びその製造方法
EP0255717A3 (en) * 1986-08-06 1990-12-05 Mect Corporation Ganglioside related compounds and method of producing the same
EP0299201A3 (de) * 1987-06-12 1990-08-22 Wilhelm Dr. Hoerrmann Fett-Aminoalkohol enthaltendes Arzneimittel
US5010059A (en) * 1987-06-26 1991-04-23 Solco Basel Ag Pharmaceutical products and lactosyl compounds
US4957741A (en) * 1988-08-02 1990-09-18 Angio-Medical Corp. Method for the treatment of gastric ulcer
US5066496A (en) * 1988-08-03 1991-11-19 Angio-Medical Corporation Composition and method for treatment of gastric and duodenal ulcers and mucosal erosions
IT1235162B (it) * 1988-12-02 1992-06-22 Fidia Farmaceutici Derivati di lisosfingolipidi
DE3916072A1 (de) * 1989-05-17 1990-11-22 Thera Ges Fuer Patente Ceramidderivate und ihre verwendung als inhibitoren der sphingolipidsynthese
DE4102817A1 (de) * 1991-01-31 1992-08-06 Merck Patent Gmbh Verfahren zur stereoselektiven herstellung von (beta)-fucopyranosyl-phosphaten und sehr reiner gdp-fucose
US5936076A (en) * 1991-08-29 1999-08-10 Kirin Beer Kabushiki Kaisha αgalactosylceramide derivatives
TW261533B (es) * 1992-07-16 1995-11-01 Kirin Brewery
WO1994009020A1 (en) * 1992-10-22 1994-04-28 Kirin Beer Kabushiki Kaisha Novel shingoglycolipid and use thereof
WO1994024142A1 (en) * 1993-04-15 1994-10-27 Kirin Beer Kabushiki Kaisha Novel sphingoglycolipid and use thereof
WO1995003028A1 (en) * 1993-07-23 1995-02-02 Morris Herstein Cosmetic, skin-renewal stimulating composition with long-term irritation control
US5663151A (en) * 1994-03-04 1997-09-02 Bristol-Myers Squibb Company Sulfated α-glycolipid derivatives as cell adhesion inhibitors
CA2142153A1 (en) * 1994-03-04 1995-09-05 Jacques Banville Sulfated .beta.-glycolipid derivatives as cell adhesion inhibitors
US5686426A (en) * 1994-11-17 1997-11-11 Bristol-Myers Squibb Company Dicarboxymethylated glycolipid derivatives as cell adhesion inhibitors
JPH10501554A (ja) * 1995-02-03 1998-02-10 コリア インスティテュート オブ サイエンス アンド テクノロジー 新規な止血剤組成物
EP0869185B9 (en) * 1997-03-03 2004-08-11 Sumitomo Chemical Company, Limited Production of optically active sphingoid compound
CA2344652C (en) 1998-09-21 2007-11-20 Otsuka Pharmaceutical Co., Ltd. Carboxymethylgalactose derivatives
US20040180852A1 (en) * 2003-03-10 2004-09-16 Cara-Lynne Schengrund Use of multivalent glycodendrimers to inhibit the activity of human immunodeficiency virus
DE102004025000A1 (de) * 2004-05-21 2005-12-08 Bayer Technology Services Gmbh Verfahren zur Herstellung von chemischen und pharmazeutischen Produkten mit integrierter Mehrsäulen-Chromatographie
CN101460458A (zh) 2006-02-15 2009-06-17 阿勒根公司 具有1－磷酸－鞘氨醇(s1p)受体拮抗剂生物活性的带芳基或者杂芳基基团的吲哚－3－羧酸的酰胺、酯、硫代酰胺和硫羟酸酯化合物
US8097644B2 (en) * 2006-03-28 2012-01-17 Allergan, Inc. Indole compounds having sphingosine-1-phosphate (S1P) receptor antagonist
CA2655947C (en) 2006-06-30 2016-08-02 The Scripps Research Institute Compositions comprising nkt cell agonist compounds and methods of use
US8524917B2 (en) * 2007-01-11 2013-09-03 Allergan, Inc. 6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
EP2125723A1 (en) 2007-01-11 2009-12-02 Allergan, Inc. 6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (s1p) receptor antagonist biological activity
CN101918360A (zh) * 2007-09-24 2010-12-15 阿勒根公司 具有1-磷酸-鞘氨醇(s1p)受体生物学活性的带芳基或者杂芳基基团的吲哚化合物
US8143291B2 (en) 2008-05-09 2012-03-27 Allergan, Inc. Indole compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (S1P) receptor biological activity
CN102119140B (zh) * 2008-08-12 2014-09-03 阿勒根公司 1-磷酸鞘氨醇（s1p）受体拮抗剂及其使用方法
WO2011008475A1 (en) 2009-06-30 2011-01-20 Allergan, Inc. Optionally substituted 2-(arylmethyl, aryloxy or arylthio) -n- pyridin-2 -yl-aryl acetamide or 2, 2-bis (aryl) -n-pyridin-2-yl acetamide compounds as medicaments for the treatment of eye diseases
US8168795B2 (en) * 2009-08-11 2012-05-01 Allergan, Inc. Selective sphingosine-1-phosphate receptor antagonists
WO2011028927A1 (en) 2009-09-04 2011-03-10 Allergan, Inc. Selective sphingosine-1-phosphate receptor antagonists
KR20120087932A (ko) 2009-09-29 2012-08-07 알러간, 인코포레이티드 스핑고신-１-포스페이트-２(ｓ１ｐ２) 수용체의 아형-선택적 조정자로서의 축합 고리 피리딘 화합물
US8741875B2 (en) 2009-11-24 2014-06-03 Allergan, Inc. Compounds as receptor modulators with therapeutic utility
AU2010324988B2 (en) * 2009-11-24 2016-05-26 Allergan, Inc. Novel compounds as receptor modulators with therapeutic utility
CN103328492A (zh) 2010-11-22 2013-09-25 阿勒根公司 作为受体调节剂具有疗效的新型化合物
US9708354B2 (en) 2013-03-15 2017-07-18 Cerenis Therapeutics Holding Sa Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
DK3363805T3 (da) 2013-03-15 2021-03-08 Cerenis Therapeutics Holding Sa Fremgangsmåder til syntese af sphingomyeliner og dihydrosphingomyeliner
EP4281435A1 (en) 2021-01-25 2023-11-29 Carbocode S.A. Method for the production of d-erythro-sphingosine and analogs thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1495548A (en) * 1974-04-16 1977-12-21 Tate & Lyle Ltd Sugar derivative containing vinyl groups and copolymers thereof
US4362720A (en) * 1977-04-14 1982-12-07 Chembiomed Ltd. Synthesis of 2-amino-2-deoxyglycoses and 2-amino-2-deoxyglycosides from glycals

Also Published As

Publication number Publication date
ES548901A0 (es) 1986-04-16
DK573384D0 (da) 1984-12-03
HUT36833A (en) 1985-10-28
ES538231A0 (es) 1986-03-16
EP0146810A2 (de) 1985-07-03
AU570087B2 (en) 1988-03-03
HU195516B (en) 1988-05-30
FI844775L (fi) 1985-06-06
CA1259610A (en) 1989-09-19
YU202784A (en) 1987-02-28
NO844815L (no) 1985-06-06
EP0146810A3 (de) 1987-05-13
AU3628684A (en) 1985-06-13
FI844775A0 (fi) 1984-12-04
DK573384A (da) 1985-06-06
ES8604986A1 (es) 1986-03-16
PL143901B1 (en) 1988-03-31
YU189686A (en) 1987-12-31
PL250710A1 (en) 1985-07-16
US4952683A (en) 1990-08-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203