ES8605801A1 - Procedimiento para la fabricacion de nuevos compuestos cina-moicos - Google Patents
Procedimiento para la fabricacion de nuevos compuestos cina-moicosInfo
- Publication number
- ES8605801A1 ES8605801A1 ES545609A ES545609A ES8605801A1 ES 8605801 A1 ES8605801 A1 ES 8605801A1 ES 545609 A ES545609 A ES 545609A ES 545609 A ES545609 A ES 545609A ES 8605801 A1 ES8605801 A1 ES 8605801A1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- preparation
- group
- therapeutical use
- cinnamoyl compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Abstract
PROCEDIMIENTO PARA LA FABRICACION DE NUEVOS COMPUESTOS CINAMOICOS. CONSISTE EN HACER CONDENSAR LOS ALDEHIDOS DE FORMULA (II) CON LOS DERIVADOS DE FORMULA (III), EN MEDIO ALCOHOLICO, EN PRESENCIA DE UNA BASE TAL COMO LA SOSA, PARA OBTENER LOS DERIVADOS DE FORMULA (I). SIENDO: AR, NUCLEO FENILO, NUCELO FENILO SUSTITUIDO, GRUPO 1,3-BENZODIOXOL, 2,2-DIMETIL-1,3-BENZODIOXOL O GRUPO DE ESTRUCTURA DE FORMULA (IV); B1, GRUPO ESCOGIDO ENTRE OH, NH2, ALQUILOXI DE C 1 A 4, ETC.; M, 0 O 1; N, 0, 1, 2 O 3; P, 1 O 2; R2 Y R3, CADA UNO DE ELLOS, H O UN GRUPO ALQUILO DE C 1 A 4. SE UTILIZA EN TERAPEUTICA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8315580A FR2552762B1 (fr) | 1983-09-30 | 1983-09-30 | Nouveaux amides piperaziniques et homopiperaziniques derives de l'acide 3,4-dioxymethylene cinnamique, leur procede de preparation et leur application en therapeutique |
Publications (2)
Publication Number | Publication Date |
---|---|
ES545609A0 ES545609A0 (es) | 1986-04-01 |
ES8605801A1 true ES8605801A1 (es) | 1986-04-01 |
Family
ID=9292689
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES536404A Expired ES8605799A1 (es) | 1983-09-30 | 1984-09-29 | Procedimiento para la fabricacion de nuevos compuestos cinamoicos |
ES545609A Expired ES8605801A1 (es) | 1983-09-30 | 1985-07-26 | Procedimiento para la fabricacion de nuevos compuestos cina-moicos |
ES545610A Expired ES8605802A1 (es) | 1983-09-30 | 1985-07-26 | Procedimiento para la fabricacion de nuevos compuestos cina-moicos |
ES545608A Expired ES8605800A1 (es) | 1983-09-30 | 1985-07-26 | Procedimiento para la fabricacion de nuevos compuestos cina-moicos |
ES545611A Expired ES8605803A1 (es) | 1983-09-30 | 1985-07-26 | Procedimiento para la fabricacion de nuevos compuestos cina-moicos |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES536404A Expired ES8605799A1 (es) | 1983-09-30 | 1984-09-29 | Procedimiento para la fabricacion de nuevos compuestos cinamoicos |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES545610A Expired ES8605802A1 (es) | 1983-09-30 | 1985-07-26 | Procedimiento para la fabricacion de nuevos compuestos cina-moicos |
ES545608A Expired ES8605800A1 (es) | 1983-09-30 | 1985-07-26 | Procedimiento para la fabricacion de nuevos compuestos cina-moicos |
ES545611A Expired ES8605803A1 (es) | 1983-09-30 | 1985-07-26 | Procedimiento para la fabricacion de nuevos compuestos cina-moicos |
Country Status (9)
Country | Link |
---|---|
US (1) | US4808582A (es) |
EP (1) | EP0136945B1 (es) |
JP (1) | JPH0631227B2 (es) |
AU (1) | AU3368484A (es) |
CA (1) | CA1227195A (es) |
DE (1) | DE3485988T2 (es) |
ES (5) | ES8605799A1 (es) |
FR (1) | FR2552762B1 (es) |
ZA (1) | ZA847640B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8512163D0 (en) * | 1985-05-14 | 1985-06-19 | Fujisawa Pharmaceutical Co | Oxothiazolidine compound |
DK386089A (da) * | 1988-08-12 | 1990-02-13 | Japan Tobacco Inc | Katekolderivater |
US6867203B2 (en) | 1998-12-29 | 2005-03-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds |
US6878700B1 (en) * | 1998-12-29 | 2005-04-12 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds |
SE0003795D0 (sv) | 2000-10-20 | 2000-10-20 | Astrazeneca Ab | Pharmaceutically useful compounds |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1139934A (en) * | 1966-08-18 | 1969-01-15 | Delalande Sa | Cinnamylpiperazine preparations |
GB1168108A (en) * | 1967-09-29 | 1969-10-22 | Delalande Sa | Amide Derivatives of 1-Piperazine Acetic Acid and Process for their Preparation |
GB1218591A (en) * | 1968-04-03 | 1971-01-06 | Delalande Sa | Derivatives of n-(3,4,5-trimethoxy cennamoyl) piperazine and their process of preparation |
US3753984A (en) * | 1971-05-26 | 1973-08-21 | Delalande Sa | Amides derived from the esters of 1-piperazine propionic acid, their method of preparation and their application to therapeutics |
FR2244518A1 (en) * | 1973-08-10 | 1975-04-18 | Delalande Sa | N-sinapyl-N'-alkoxyalkyl or-aminocarbonylmethyl-piperazines - as vasodilators, diuretics, antihypertensive and antiulcer agents |
FR2278340A1 (fr) * | 1974-07-17 | 1976-02-13 | Delalande Sa | Nouveau derive de la n-(trimethoxy-3,4,5 cinnamoyl) piperazine, ses sels d'addition d'acides, son procede de preparation et son application en therapeutique |
GB1473262A (en) * | 1974-11-20 | 1977-05-11 | Delalande Sa | Derivatives of n-3,4,5-trimethoxy cinnamoyl-piperazine their process of preparation and their therapeutic application |
FR2460942A1 (fr) * | 1979-07-12 | 1981-01-30 | Delalande Sa | Nouveaux derives de l'acide a-amino butyrique, leur procede de preparation et leur application en therapeutique |
JPS5732255A (en) * | 1980-08-05 | 1982-02-20 | Kowa Co | Trimethoxyphenyl derivative |
US4397855A (en) * | 1981-06-26 | 1983-08-09 | Warner-Lambert Company | 4-(Substituted)-α, α-dimethyl-1-piperazine pentanoic acids and derivatives as anti-arteriosclerotic agents and method |
JPS5888370A (ja) * | 1981-11-19 | 1983-05-26 | Hokuriku Seiyaku Co Ltd | 1−(3,4,5−トリメトキシシンナモイル)−4−アミノカルボニルエチル置換ピペラジン及びホモピペラジン誘導体、及びその製造方法 |
IT1151104B (it) * | 1982-02-04 | 1986-12-17 | Delalande Sa | Impiego terapeutico di derivati (1-cinnamoil oppure 1-fenetil-carbonil)piperazinici |
FR2522325B1 (fr) * | 1982-02-26 | 1985-08-09 | Delalande Sa | Nouveaux derives aryliques de la piperazine, de l'homopiperazine et de n,n'-dialkyl diamino-1,2 ethane, leur procede de preparation et leur application en therapeutique |
-
1983
- 1983-09-30 FR FR8315580A patent/FR2552762B1/fr not_active Expired
-
1984
- 1984-09-25 CA CA000463980A patent/CA1227195A/en not_active Expired
- 1984-09-26 DE DE8484401923T patent/DE3485988T2/de not_active Expired - Fee Related
- 1984-09-26 EP EP84401923A patent/EP0136945B1/fr not_active Expired - Lifetime
- 1984-09-28 JP JP59203956A patent/JPH0631227B2/ja not_active Expired - Lifetime
- 1984-09-28 AU AU33684/84A patent/AU3368484A/en not_active Abandoned
- 1984-09-29 ES ES536404A patent/ES8605799A1/es not_active Expired
- 1984-09-29 ZA ZA847640A patent/ZA847640B/xx unknown
-
1985
- 1985-07-26 ES ES545609A patent/ES8605801A1/es not_active Expired
- 1985-07-26 ES ES545610A patent/ES8605802A1/es not_active Expired
- 1985-07-26 ES ES545608A patent/ES8605800A1/es not_active Expired
- 1985-07-26 ES ES545611A patent/ES8605803A1/es not_active Expired
-
1987
- 1987-03-19 US US07/028,092 patent/US4808582A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES545609A0 (es) | 1986-04-01 |
JPS60105662A (ja) | 1985-06-11 |
EP0136945A2 (fr) | 1985-04-10 |
DE3485988D1 (de) | 1992-12-24 |
ES8605802A1 (es) | 1986-04-01 |
EP0136945A3 (en) | 1985-07-10 |
ES545608A0 (es) | 1986-04-01 |
DE3485988T2 (de) | 1993-04-15 |
JPH0631227B2 (ja) | 1994-04-27 |
CA1227195A (en) | 1987-09-22 |
US4808582A (en) | 1989-02-28 |
ES8605800A1 (es) | 1986-04-01 |
ES8605803A1 (es) | 1986-04-01 |
ES8605799A1 (es) | 1986-04-01 |
FR2552762A1 (fr) | 1985-04-05 |
AU3368484A (en) | 1985-04-04 |
FR2552762B1 (fr) | 1986-07-25 |
EP0136945B1 (fr) | 1992-11-19 |
ES545610A0 (es) | 1986-04-01 |
ES536404A0 (es) | 1986-04-01 |
ES545611A0 (es) | 1986-04-01 |
ZA847640B (en) | 1985-05-29 |
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