ES8605523A1 - Un procedimiento para la preparacion de derivados de hidantoina. - Google Patents

Un procedimiento para la preparacion de derivados de hidantoina.

Info

Publication number
ES8605523A1
ES8605523A1 ES539942A ES539942A ES8605523A1 ES 8605523 A1 ES8605523 A1 ES 8605523A1 ES 539942 A ES539942 A ES 539942A ES 539942 A ES539942 A ES 539942A ES 8605523 A1 ES8605523 A1 ES 8605523A1
Authority
ES
Spain
Prior art keywords
chroman
imidazolidine
spiro
diones
antiarrhythmic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES539942A
Other languages
English (en)
Other versions
ES539942A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of ES8605523A1 publication Critical patent/ES8605523A1/es
Publication of ES539942A0 publication Critical patent/ES539942A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE HIDANTOINA, DE FORMULA GENERAL (I), EN LA QUE X1 Y X2 SON IGUALES O DIFERENTES Y REPRESENTAN CADA UNO DE ELLOS HIDROGENO, HALOGENO O ALQUILO INFERIOR; R1 Y R2 REPRESENTAN HIDROGENO O ALQUILO INFERIOR; N REPRESENTA UN NUMERO ENTERO DE 2 A 7; Y Z REPRESENTA UN RADICAL, Y SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II) CON UN COMPUESTO DE FORMULA GENERAL: X-(CH2)N-Y, PARA OBTENER UN COMPUESTO DE FORMULA GENERAL (III). DICHO COMPUESTO OBTENIDO DE FORMULA GENERAL (III) SE HACE REACCIONAR CON UN COMPUESTO DE FORMULA GENERAL: R3O-HN-R4O, PARA OBTENER EL COMPUESTO DE FORMULA GENERAL (I) BUSCADO. DE APLICACION COMO AGENTES ANTI-ARRITMICOS.
ES539942A 1984-01-30 1985-01-29 Un procedimiento para la preparacion de derivados de hidantoina. Expired ES8605523A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59013442A JPS60158190A (ja) 1984-01-30 1984-01-30 ヒダントイン誘導体およびその製法ならびにそれを含有する医薬

Publications (2)

Publication Number Publication Date
ES8605523A1 true ES8605523A1 (es) 1986-03-16
ES539942A0 ES539942A0 (es) 1986-03-16

Family

ID=11833246

Family Applications (2)

Application Number Title Priority Date Filing Date
ES539942A Expired ES8605523A1 (es) 1984-01-30 1985-01-29 Un procedimiento para la preparacion de derivados de hidantoina.
ES548960A Expired ES8606293A1 (es) 1984-01-30 1985-11-15 Un procedimiento para la preparacion de derivados de hidan- toina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES548960A Expired ES8606293A1 (es) 1984-01-30 1985-11-15 Un procedimiento para la preparacion de derivados de hidan- toina

Country Status (23)

Country Link
US (1) US4650798A (es)
JP (1) JPS60158190A (es)
KR (1) KR870001681B1 (es)
AU (1) AU585207B2 (es)
BE (1) BE901591A (es)
CA (1) CA1249271A (es)
CH (1) CH662354A5 (es)
DE (1) DE3503074A1 (es)
DK (1) DK158668C (es)
ES (2) ES8605523A1 (es)
FI (1) FI83873C (es)
FR (1) FR2558835B1 (es)
GB (1) GB2155466B (es)
HU (1) HU194885B (es)
IE (1) IE850136L (es)
IT (1) IT1184144B (es)
MX (1) MX160579A (es)
NL (1) NL8500248A (es)
NZ (1) NZ210979A (es)
PH (1) PH21920A (es)
SE (1) SE462849B (es)
SU (3) SU1468424A3 (es)
ZA (1) ZA85655B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2708507B2 (ja) * 1988-04-07 1998-02-04 株式会社三和化学研究所 （ｄ）‐６‐フルオロ‐２，３‐ジヒドロ‐２’，５’‐ジオキソ‐スピロ［４Ｈ‐１‐ベンゾピラン‐４，４’‐イミダゾリジン］‐２‐カルボキサミド誘導体、これらの製法及び用途
JPH0276882A (ja) * 1988-06-20 1990-03-16 Eisai Co Ltd 光学活性ヒダントイン誘導体
US5206240A (en) * 1989-12-08 1993-04-27 Merck & Co., Inc. Nitrogen-containing spirocycles
IL96507A0 (en) * 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
US5382587A (en) * 1993-06-30 1995-01-17 Merck & Co., Inc. Spirocycles
US5403846A (en) * 1993-11-22 1995-04-04 Merck & Co., Inc. Spirocycles
US5439914A (en) * 1994-02-18 1995-08-08 Merck & Co., Inc. Spirocycles
GB2355264A (en) 1999-09-30 2001-04-18 Merck & Co Inc Spirohydantoin derivatives useful as alpha 1a adrenoceptor antagonists

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2455046A1 (fr) * 1979-04-25 1980-11-21 Science Union & Cie Nouvelles hydantoines, leur procede de preparation et leur emploi comme medicament

Also Published As

Publication number Publication date
GB2155466B (en) 1987-10-07
SE462849B (sv) 1990-09-10
BE901591A (fr) 1985-07-29
SE8500387L (sv) 1985-07-31
SU1468424A3 (ru) 1989-03-23
GB2155466A (en) 1985-09-25
ES8606293A1 (es) 1986-04-16
ES539942A0 (es) 1986-03-16
FR2558835A1 (fr) 1985-08-02
SE8500387D0 (sv) 1985-01-28
HU194885B (en) 1988-03-28
CA1249271A (en) 1989-01-24
US4650798A (en) 1987-03-17
CH662354A5 (fr) 1987-09-30
DK39585A (da) 1985-07-31
NZ210979A (en) 1987-05-29
JPH0441149B2 (es) 1992-07-07
ES548960A0 (es) 1986-04-16
SU1609453A3 (ru) 1990-11-23
FI83873B (fi) 1991-05-31
PH21920A (en) 1988-04-08
FR2558835B1 (fr) 1990-05-18
AU585207B2 (en) 1989-06-15
HUT38646A (en) 1986-06-30
FI850302L (fi) 1985-07-31
IE850136L (en) 1985-07-30
DK158668B (da) 1990-07-02
NL8500248A (nl) 1985-08-16
KR870001681B1 (ko) 1987-09-22
SU1445559A3 (ru) 1988-12-15
MX160579A (es) 1990-03-27
IT8519296A0 (it) 1985-01-30
JPS60158190A (ja) 1985-08-19
FI83873C (fi) 1991-09-10
KR850005442A (ko) 1985-08-26
DK158668C (da) 1990-11-26
AU3806285A (en) 1985-08-08
DK39585D0 (da) 1985-01-29
IT1184144B (it) 1987-10-22
DE3503074A1 (de) 1985-08-08
FI850302A0 (fi) 1985-01-23
GB8502308D0 (en) 1985-02-27
ZA85655B (en) 1985-08-28

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