ES8606293A1 - Un procedimiento para la preparacion de derivados de hidan- toina - Google Patents
Un procedimiento para la preparacion de derivados de hidan- toinaInfo
- Publication number
- ES8606293A1 ES8606293A1 ES548960A ES548960A ES8606293A1 ES 8606293 A1 ES8606293 A1 ES 8606293A1 ES 548960 A ES548960 A ES 548960A ES 548960 A ES548960 A ES 548960A ES 8606293 A1 ES8606293 A1 ES 8606293A1
- Authority
- ES
- Spain
- Prior art keywords
- chroman
- imidazolidine
- spiro
- diones
- antiarrhythmic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
METODO DE OBTENCION DE DERIVADOS DE HIDANTOINA Y SUS SALES DE FORMULA (I) DONDE X1 Y X2 SON IGUALES O DIFERENTES PUDIENDO SER HIDROGENO, HALOGENO, ALQUILO INFERIOR, ALCOXI INFERIOR O NITRO, O BIEN JUNTOS FORMAN UN GRUPO ALQUILENDIOXI; R1 Y R2 SON IGUALES O DIFERENTES Y REPRESENTAN HIDROGENO, ALQUILO INFERIOR, O BIEN UNIDOS FORMAN UNGRUPO CICLOALQUILO; N TOMA LOS VALORES DE 2 A 7 Y Z REPRESENTA UNA AMINA TERCIARIA O BIEN UN GRUPO PIPERIDIL DOBLEMENTE SUSTITUIDO EN POSICION 3 POR RADICALES, O TAMBIEN UN GRUPO PIPERIDIL CON UN HIDROXI EN POSICION 2. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) DONDE X1, X2, R1 Y R2 TIENEN EL SIGNIFICADO ANTERIOR, CON UN HALURO DE ALQUILAMINA. DE UTILIZACION FARMACOLOGICA POR SU ACTIVIDAD ANTI-ARRITMICA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP59013442A JPS60158190A (ja) | 1984-01-30 | 1984-01-30 | ヒダントイン誘導体およびその製法ならびにそれを含有する医薬 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES548960A0 ES548960A0 (es) | 1986-04-16 |
ES8606293A1 true ES8606293A1 (es) | 1986-04-16 |
Family
ID=11833246
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES539942A Expired ES8605523A1 (es) | 1984-01-30 | 1985-01-29 | Un procedimiento para la preparacion de derivados de hidantoina. |
ES548960A Expired ES8606293A1 (es) | 1984-01-30 | 1985-11-15 | Un procedimiento para la preparacion de derivados de hidan- toina |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES539942A Expired ES8605523A1 (es) | 1984-01-30 | 1985-01-29 | Un procedimiento para la preparacion de derivados de hidantoina. |
Country Status (23)
Country | Link |
---|---|
US (1) | US4650798A (es) |
JP (1) | JPS60158190A (es) |
KR (1) | KR870001681B1 (es) |
AU (1) | AU585207B2 (es) |
BE (1) | BE901591A (es) |
CA (1) | CA1249271A (es) |
CH (1) | CH662354A5 (es) |
DE (1) | DE3503074A1 (es) |
DK (1) | DK158668C (es) |
ES (2) | ES8605523A1 (es) |
FI (1) | FI83873C (es) |
FR (1) | FR2558835B1 (es) |
GB (1) | GB2155466B (es) |
HU (1) | HU194885B (es) |
IE (1) | IE850136L (es) |
IT (1) | IT1184144B (es) |
MX (1) | MX160579A (es) |
NL (1) | NL8500248A (es) |
NZ (1) | NZ210979A (es) |
PH (1) | PH21920A (es) |
SE (1) | SE462849B (es) |
SU (3) | SU1468424A3 (es) |
ZA (1) | ZA85655B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2708507B2 (ja) * | 1988-04-07 | 1998-02-04 | 株式会社三和化学研究所 | (d)‐6‐フルオロ‐2,3‐ジヒドロ‐2’,5’‐ジオキソ‐スピロ[4H‐1‐ベンゾピラン‐4,4’‐イミダゾリジン]‐2‐カルボキサミド誘導体、これらの製法及び用途 |
JPH0276882A (ja) * | 1988-06-20 | 1990-03-16 | Eisai Co Ltd | 光学活性ヒダントイン誘導体 |
IL96507A0 (en) * | 1989-12-08 | 1991-08-16 | Merck & Co Inc | Nitrogen-containing spirocycles and pharmaceutical compositions containing them |
US5206240A (en) * | 1989-12-08 | 1993-04-27 | Merck & Co., Inc. | Nitrogen-containing spirocycles |
US5382587A (en) * | 1993-06-30 | 1995-01-17 | Merck & Co., Inc. | Spirocycles |
US5403846A (en) * | 1993-11-22 | 1995-04-04 | Merck & Co., Inc. | Spirocycles |
US5439914A (en) * | 1994-02-18 | 1995-08-08 | Merck & Co., Inc. | Spirocycles |
GB2355264A (en) * | 1999-09-30 | 2001-04-18 | Merck & Co Inc | Spirohydantoin derivatives useful as alpha 1a adrenoceptor antagonists |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2455046A1 (fr) * | 1979-04-25 | 1980-11-21 | Science Union & Cie | Nouvelles hydantoines, leur procede de preparation et leur emploi comme medicament |
-
1984
- 1984-01-30 JP JP59013442A patent/JPS60158190A/ja active Granted
-
1985
- 1985-01-22 IE IE850136A patent/IE850136L/xx unknown
- 1985-01-23 PH PH31760A patent/PH21920A/en unknown
- 1985-01-23 FI FI850302A patent/FI83873C/fi not_active Application Discontinuation
- 1985-01-24 AU AU38062/85A patent/AU585207B2/en not_active Ceased
- 1985-01-25 US US06/695,152 patent/US4650798A/en not_active Expired - Fee Related
- 1985-01-28 CA CA000472972A patent/CA1249271A/en not_active Expired
- 1985-01-28 SE SE8500387A patent/SE462849B/sv not_active IP Right Cessation
- 1985-01-28 MX MX8350A patent/MX160579A/es unknown
- 1985-01-28 ZA ZA85655A patent/ZA85655B/xx unknown
- 1985-01-28 CH CH375/85A patent/CH662354A5/fr not_active IP Right Cessation
- 1985-01-29 ES ES539942A patent/ES8605523A1/es not_active Expired
- 1985-01-29 HU HU85323A patent/HU194885B/hu not_active IP Right Cessation
- 1985-01-29 SU SU853856860A patent/SU1468424A3/ru active
- 1985-01-29 NL NL8500248A patent/NL8500248A/xx not_active Application Discontinuation
- 1985-01-29 DK DK039585A patent/DK158668C/da not_active IP Right Cessation
- 1985-01-29 NZ NZ210979A patent/NZ210979A/en unknown
- 1985-01-29 BE BE2/60602A patent/BE901591A/fr not_active IP Right Cessation
- 1985-01-29 KR KR1019850000539A patent/KR870001681B1/ko not_active IP Right Cessation
- 1985-01-30 FR FR858501296A patent/FR2558835B1/fr not_active Expired - Fee Related
- 1985-01-30 GB GB08502308A patent/GB2155466B/en not_active Expired
- 1985-01-30 IT IT19296/85A patent/IT1184144B/it active
- 1985-01-30 DE DE19853503074 patent/DE3503074A1/de not_active Withdrawn
- 1985-11-15 ES ES548960A patent/ES8606293A1/es not_active Expired
-
1986
- 1986-04-02 SU SU864027211A patent/SU1609453A3/ru active
- 1986-04-02 SU SU864027225A patent/SU1445559A3/ru active
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Patent lapsed |
Effective date: 19960506 |