ES8604593A1 - Un procedimiento para preparar derivados de imidazo(1,2-a) quinoleinas - Google Patents

Un procedimiento para preparar derivados de imidazo(1,2-a) quinoleinas

Info

Publication number
ES8604593A1
ES8604593A1 ES545929A ES545929A ES8604593A1 ES 8604593 A1 ES8604593 A1 ES 8604593A1 ES 545929 A ES545929 A ES 545929A ES 545929 A ES545929 A ES 545929A ES 8604593 A1 ES8604593 A1 ES 8604593A1
Authority
ES
Spain
Prior art keywords
quinolines
imidazo
preparation
therapeutical use
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES545929A
Other languages
English (en)
Other versions
ES545929A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Publication of ES8604593A1 publication Critical patent/ES8604593A1/es
Publication of ES545929A0 publication Critical patent/ES545929A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE IMIDAZO1,2-AQUINOLEINAS, DE FORMULA GENERAL (I) EN LA QUE X REPRESENTA HIDROGENO, HALOGENO, UN GRUPO METILO O UN GRUPO METILTIO; Y REPRESENTA HIDROGENO O UN HALOGENO; Y R1 Y R2 REPRESENTAN CADA UNO DE ELLOS HIDROGENO O UN GRUPO METILO O ETILO, Y SUS SALES DE ADICION DE ACIDOS FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN SOMETER A LA QUINOLEINA DE FORMULA GENERAL (II) A LA ACCION DE UNA A-BROMO-ACETOFENONA, PARA OBTENER UN COMPUESTO IONICO DE FORMULA GENERAL (III). A CONTINUACION EL COMPUESTO DE FORMULA GENERAL (III) SE SOMETE A UNA SERIE DE PROCESOS EN CADENA HASTA OBTENER EL COMPUESTO DE FORMULA GENERAL (I). DE APLICACION EN TERAPEUTICA
ES545929A 1984-08-07 1985-08-06 Un procedimiento para preparar derivados de imidazo(1,2-a) quinoleinas Expired ES8604593A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8412446A FR2568879B1 (fr) 1984-08-07 1984-08-07 Imidazo(1,2-a)quinolines, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
ES8604593A1 true ES8604593A1 (es) 1986-02-01
ES545929A0 ES545929A0 (es) 1986-02-01

Family

ID=9306855

Family Applications (1)

Application Number Title Priority Date Filing Date
ES545929A Expired ES8604593A1 (es) 1984-08-07 1985-08-06 Un procedimiento para preparar derivados de imidazo(1,2-a) quinoleinas

Country Status (20)

Country Link
EP (1) EP0172097B1 (es)
JP (1) JPS6147484A (es)
KR (1) KR860001814A (es)
AR (1) AR240674A1 (es)
AT (1) ATE41001T1 (es)
AU (1) AU573880B2 (es)
CA (1) CA1263389A (es)
DE (1) DE3568430D1 (es)
DK (1) DK161963B (es)
ES (1) ES8604593A1 (es)
FI (1) FI79314C (es)
FR (1) FR2568879B1 (es)
GR (1) GR851929B (es)
HU (1) HU199838B (es)
IL (1) IL76019A0 (es)
MX (1) MX161035A (es)
NO (1) NO162188C (es)
NZ (1) NZ213014A (es)
PT (1) PT80920B (es)
ZA (1) ZA855937B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2593179B1 (fr) * 1986-01-22 1988-04-01 Synthelabo Derives d'imidazo(1,2-a)quinoleines, leur preparation et leur application en therapeutique
FR2606410B1 (fr) * 1986-11-07 1989-02-24 Synthelabo Imidazopyridines, leur preparation et leur application en therapeutique
EP0607076A1 (fr) * 1993-01-15 1994-07-20 Synthelabo Dérivés de 9h-imidazo 1,2-a benzimidazole-3-acétamide à activité GABA
FR2707987B1 (fr) * 1993-07-22 1995-09-08 Synthelabo Dérivés de 9H-imidazo[1,2-a]benzimidazole-3-acétamide, leur préparation et leur application en thérapeutique .
FR2700544B1 (fr) * 1993-01-15 1995-02-17 Synthelabo Dérivés de 9H-imidazo[1,2-a]benzimidazole-3-acétamide, leur préparation et leur application en thérapeutique.
FR2700547B1 (fr) * 1993-01-15 1995-02-17 Synthelabo Dérivés d'imidazo[2,1-b]benzosélénazole-3-acétamide, leur préparation et leur application en thérapeutique.
FR2719843B1 (fr) * 1994-05-10 1996-06-07 Synthelabo Dérivés de 5,6-dihydro-4h-imidazo [2',1':2,3] imidazo-[4,5,1-ij] quinoléine et de 4,5-dihydroimidazo [1,2-a] pyrrolo-[1,2,3-cd] benzimidazole, leur préparation et leur application en thérapeutique.
FR2722501B1 (fr) * 1994-07-13 1996-08-09 Synthelabo Derives de 9h-imidazo(1,2-a)benzimidazole-3-acetamide, leur preparation et leur application en therapeutique

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2492382A1 (fr) * 1980-10-22 1982-04-23 Synthelabo Derives d'imidazo (1,2-a) pyridine, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
IL76019A0 (en) 1985-12-31
ZA855937B (en) 1986-03-26
CA1263389A (en) 1989-11-28
NZ213014A (en) 1988-05-30
MX161035A (es) 1990-07-11
PT80920A (fr) 1985-09-01
HUT38636A (en) 1986-06-30
AU4581485A (en) 1986-02-13
NO162188C (no) 1989-11-29
JPS6147484A (ja) 1986-03-07
DK161963B (da) 1991-09-02
AR240674A1 (es) 1990-08-31
DE3568430D1 (en) 1989-04-06
FR2568879B1 (fr) 1986-12-12
FI79314B (fi) 1989-08-31
FI79314C (fi) 1989-12-11
ES545929A0 (es) 1986-02-01
AU573880B2 (en) 1988-06-23
NO162188B (no) 1989-08-14
NO853099L (no) 1986-02-10
ATE41001T1 (de) 1989-03-15
GR851929B (es) 1985-12-09
FI853027L (fi) 1986-02-08
PT80920B (pt) 1987-12-30
DK356985A (da) 1986-02-08
KR860001814A (ko) 1986-03-22
HU199838B (en) 1990-03-28
FR2568879A1 (fr) 1986-02-14
FI853027A0 (fi) 1985-08-06
EP0172097A1 (fr) 1986-02-19
DK356985D0 (da) 1985-08-06
EP0172097B1 (fr) 1989-03-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603