ES8604163A1 - Procedimiento para preparar nuevos bencimidazoles - Google Patents

Procedimiento para preparar nuevos bencimidazoles

Info

Publication number
ES8604163A1
ES8604163A1 ES544117A ES544117A ES8604163A1 ES 8604163 A1 ES8604163 A1 ES 8604163A1 ES 544117 A ES544117 A ES 544117A ES 544117 A ES544117 A ES 544117A ES 8604163 A1 ES8604163 A1 ES 8604163A1
Authority
ES
Spain
Prior art keywords
denotes
group
alkoxy
benzimidazoles
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES544117A
Other languages
English (en)
Other versions
ES544117A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES544117A0 publication Critical patent/ES544117A0/es
Publication of ES8604163A1 publication Critical patent/ES8604163A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE BENCIMIDAZOLES, SUS TAUTOMEROS Y SUS SALES DE ADICION DE ACIDOS, DE FORMULA (I), EN LA QUE R3 REPRESENTA HIDROGENO O ALCOXI; Y R1, R2 Y R4 UEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO, DE FORMULA (II), CON UN HALOGENURO DE FORMULA W-R5, EN LAS QUE U REPRESENTA HIDROXI O MERCAPTO, R+ 2 ES HIDROXI O LO MISMO QUE R2, R3 ES HIDROXI O LO MISMO QUE R3, W ES UN GRUPO LABIL NUCLEOFILO, TAL COMO CLORO, BROMO O YODO, Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE INSUFICIENCIAS CARDIACAS.
ES544117A 1983-12-23 1985-06-13 Procedimiento para preparar nuevos bencimidazoles Expired ES8604163A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3346575A DE3346575A1 (de) 1983-12-23 1983-12-23 Neue benzimidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
ES544117A0 ES544117A0 (es) 1986-01-16
ES8604163A1 true ES8604163A1 (es) 1986-01-16

Family

ID=6217793

Family Applications (5)

Application Number Title Priority Date Filing Date
ES538929A Granted ES538929A0 (es) 1983-12-23 1984-12-21 Procedimiento para preparar bencimidazoles
ES544118A Expired ES8604164A1 (es) 1983-12-23 1985-06-13 Procedimiento para preparar nuevos bencimidazoles
ES544116A Expired ES8604162A1 (es) 1983-12-23 1985-06-13 Procedimiento para preparar nuevos bencimidazoles
ES544117A Expired ES8604163A1 (es) 1983-12-23 1985-06-13 Procedimiento para preparar nuevos bencimidazoles
ES544119A Expired ES8604165A1 (es) 1983-12-23 1985-06-13 Procedimiento para preparar nuevos bencimidazoles

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES538929A Granted ES538929A0 (es) 1983-12-23 1984-12-21 Procedimiento para preparar bencimidazoles
ES544118A Expired ES8604164A1 (es) 1983-12-23 1985-06-13 Procedimiento para preparar nuevos bencimidazoles
ES544116A Expired ES8604162A1 (es) 1983-12-23 1985-06-13 Procedimiento para preparar nuevos bencimidazoles

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES544119A Expired ES8604165A1 (es) 1983-12-23 1985-06-13 Procedimiento para preparar nuevos bencimidazoles

Country Status (14)

Country Link
EP (1) EP0148431A1 (es)
JP (1) JPS60156676A (es)
KR (1) KR850004467A (es)
AU (1) AU3704284A (es)
DD (1) DD232697A5 (es)
DE (1) DE3346575A1 (es)
DK (1) DK597484A (es)
ES (5) ES538929A0 (es)
FI (1) FI845084L (es)
HU (1) HU193073B (es)
IL (1) IL73897A0 (es)
NO (1) NO845169L (es)
PT (1) PT79718B (es)
ZA (1) ZA849972B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU85544A1 (fr) * 1984-09-19 1986-04-03 Cird Derives heterocycliques aromatiques,leur procede de preparation et leur application dans les domaines therapeutique et cosmetique
DE3522230A1 (de) * 1985-06-21 1987-01-02 Thomae Gmbh Dr K Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
FR2677020B1 (fr) * 1991-05-31 1993-08-27 Cird Galderma Composes derives de benzimidazole, leur procede de preparation et leur utilisation dans les domaines therapeutique et cosmetique.
US5821258A (en) * 1994-12-27 1998-10-13 Mitsui Chemicals, Inc. Phenylbenzimidazole derivatives
AU714873B2 (en) 1995-08-02 2000-01-13 Newcastle University Ventures Limited Benzimidazole compounds
US5942532A (en) * 1997-09-05 1999-08-24 Ortho Pharmaceutical Corporation 2-substituted phenyl-benzimidazole antibacterial agents
DE60221866T2 (de) 2001-10-19 2008-05-29 Ortho-Mcneil Pharmaceutical, Inc. 2-PHENYL BENZIMIDAZOLE UND IMIDAZO-i4,5ö-PYRIDINE ALS CDS1/CHK2-INHIBITOREN UND ADJUVANTIEN IN DER CHEMOTHERAPIE ODER STRAHLUNGSTHERAPIE ZUR BEHANDLUNG VON KREBS
CA2504044A1 (en) * 2002-11-01 2004-05-21 Merck & Co., Inc. Carbonylamino-benzimidazole derivatives as androgen receptor modulators
JP4726235B2 (ja) 2003-04-17 2011-07-20 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 癌の処置のためのチェックポイントキナーゼｃｄｓ１（ｃｈｋ２）インヒビターとしての２−フェニル−ベンズイミダゾールおよび２−フェニル−イミダゾ−‘４，５！−ピリジン誘導体
ATE507206T1 (de) 2004-06-30 2011-05-15 Janssen Pharmaceutica Nv Arylsubstituiertes benzimidazol- und imidazopyridinether als wirkstoffe gegen krebs
WO2012086848A1 (en) 2010-12-24 2012-06-28 Sumitomo Chemical Company, Limited Fused heterocyclic compound and use for pest control thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH350763A (de) * 1958-10-14 1960-12-15 Ciba Geigy Verwendung von Azolverbindungen als Schutzmittel gegen ultraviolette Strahlung
DE1447733B2 (de) * 1963-12-23 1977-04-21 Hoechst Ag, 6000 Frankfurt 2-(3,5-dihydroxyphenyl)-benzimidazolderivate
IL23847A (en) * 1964-08-07 1969-02-27 Merck & Co Inc Benzimidazoles useful as antifungals
FR1569337A (es) * 1968-06-18 1969-05-30
DE2742093A1 (de) * 1977-09-19 1979-03-29 Cassella Ag Verfahren zur herstellung von 2-(3'- bzw. 4'-aminophenyl)-5(bzw. 6) -aminobenzimidazolen
DE2927987A1 (de) * 1979-07-11 1981-02-05 Thomae Gmbh Dr K Neue 2-alkoxyphenyl-imidazo eckige klammer auf 4,5-b eckige klammer zu pyridine, deren herstellung und deren verwendung als arzneimittel
DE3224512A1 (de) * 1982-07-01 1984-01-05 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
HUT37763A (en) 1986-02-28
ES8604164A1 (es) 1986-01-16
ES8601913A1 (es) 1985-11-16
DE3346575A1 (de) 1985-07-04
DK597484A (da) 1985-06-24
JPS60156676A (ja) 1985-08-16
ES544116A0 (es) 1986-01-16
PT79718A (de) 1985-01-01
HU193073B (en) 1987-08-28
ES544117A0 (es) 1986-01-16
FI845084A0 (fi) 1984-12-21
EP0148431A1 (de) 1985-07-17
DD232697A5 (de) 1986-02-05
ES8604162A1 (es) 1986-01-16
FI845084L (fi) 1985-06-24
DK597484D0 (da) 1984-12-13
ES544119A0 (es) 1986-01-16
ES8604165A1 (es) 1986-01-16
NO845169L (no) 1985-06-24
PT79718B (de) 1986-12-30
ES544118A0 (es) 1986-01-16
KR850004467A (ko) 1985-07-15
ZA849972B (en) 1986-08-27
IL73897A0 (en) 1985-03-31
ES538929A0 (es) 1985-11-16
AU3704284A (en) 1985-07-04

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