ES8604018A1 - Un procedimiento para la preparacion de injertos oftalmicos solidos. - Google Patents

Un procedimiento para la preparacion de injertos oftalmicos solidos.

Info

Publication number
ES8604018A1
ES8604018A1 ES537584A ES537584A ES8604018A1 ES 8604018 A1 ES8604018 A1 ES 8604018A1 ES 537584 A ES537584 A ES 537584A ES 537584 A ES537584 A ES 537584A ES 8604018 A1 ES8604018 A1 ES 8604018A1
Authority
ES
Spain
Prior art keywords
formulation containing
ophthalmic formulation
norfloxacin
related antibiotics
containing norfloxacin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES537584A
Other languages
English (en)
Other versions
ES537584A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES537584A0 publication Critical patent/ES537584A0/es
Publication of ES8604018A1 publication Critical patent/ES8604018A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE INJERTOS OFTALMICOS SOLIDOS, QUE COMPRENDEN COMO INGREDIENTE ACTIVO UN ANTIBIOTICO SELECCIONADO ENTRE NORFLOXACINA, OFLOXACINA, PERFLOXACINA, AT-2266 Y BAYER 09867. COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE SOMETE UNA MEZCLA FORMADA POR EL INGREDIENTE ACTIVO Y UN POLIMERO SOLUBLE EN AGUA, A UNA PRESION DE APROXIMADAMENTE 4.724 KILOS Y A UNA TEMPERATURA DE APROXIMADAMENTE 149 GRADOS, DURANTE 1 A 4 MINUTOS; SEGUNDA, A CONTINUACION SE ENFRIA EL PRODUCTO RESULTANTE Y SE LE CORTA EN TROZOS DE TAMAÑO ADECUADO; Y POR ULTIMO, EL PRODUCTO TROCEADO SE HUMIDIFICA A UNA HUMEDAD RELATIVA DEL 88% A 30 GRADOS, DURANTE DOS A CUATRO DIAS.
ES537584A 1983-11-14 1984-11-12 Un procedimiento para la preparacion de injertos oftalmicos solidos. Expired ES8604018A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/551,775 US4551456A (en) 1983-11-14 1983-11-14 Ophthalmic use of norfloxacin and related antibiotics

Publications (2)

Publication Number Publication Date
ES537584A0 ES537584A0 (es) 1986-01-16
ES8604018A1 true ES8604018A1 (es) 1986-01-16

Family

ID=24202636

Family Applications (1)

Application Number Title Priority Date Filing Date
ES537584A Expired ES8604018A1 (es) 1983-11-14 1984-11-12 Un procedimiento para la preparacion de injertos oftalmicos solidos.

Country Status (12)

Country Link
US (1) US4551456A (es)
EP (1) EP0142426A3 (es)
JP (1) JPS60123420A (es)
AU (1) AU567979B2 (es)
CA (1) CA1241599A (es)
DK (1) DK537784A (es)
ES (1) ES8604018A1 (es)
GR (1) GR80874B (es)
IL (1) IL73426A (es)
NZ (1) NZ210104A (es)
PT (1) PT79454B (es)
ZA (1) ZA848829B (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3517709A1 (de) * 1985-01-05 1986-07-10 Bayer Ag Basische zubereitungen von chinoloncarbonsaeuren
FR2588189B1 (fr) * 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
DE3542972A1 (de) * 1985-12-05 1987-06-11 Merck Patent Gmbh Pharmakadepot
US4692454A (en) * 1986-02-03 1987-09-08 Warner-Lambert Company Opthalmic use of quinolone antibiotics
JPS635091A (ja) * 1986-06-26 1988-01-11 Senjiyu Seiyaku Kk 着色防止方法
JP2558107B2 (ja) * 1986-12-18 1996-11-27 第一製薬株式会社 外用剤
CA1309024C (en) * 1986-12-19 1992-10-20 Hiromitsu Seki Aqueous pharmaceutical composition containing s-(-)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl -7-oxo-2,3,-dihydro-7h-pyridol[1,2,3,-de][1,4]benzoxazine -6-carboxylic acid
JPH0696533B2 (ja) * 1987-01-14 1994-11-30 北陸製薬株式会社 キノロンカルボン酸の水性組成物
IE873504L (en) * 1987-01-28 1988-07-28 Harvard College Stabilized ophthalmic compositions
DE3881939T2 (de) * 1987-02-26 1993-09-30 Daiichi Seiyaku Co Verwendung von Ofloxacin zur lokalen Behandlung oder Prophylaxe von Beschwerden der Wurzelhaut der Zähne.
JPH01258620A (ja) * 1988-04-08 1989-10-16 Dai Ichi Seiyaku Co Ltd 耳疾患用局所製剤
US4960799A (en) * 1988-09-13 1990-10-02 Ciba-Geigy Corporation Stabilized aqueous solutions of pharmaceutically acceptable salts of ortho-(2,6-dichlorophenyl)-aminophenylacetic acid for opthalmic use
FR2655545B1 (fr) * 1989-12-11 1994-06-10 Rhone Poulenc Sante Nouvelle application therapeutique des derives des fluoroquinolones.
FR2665635A1 (fr) * 1990-08-10 1992-02-14 Merck Sharp & Dohme Composition pharmaceutique fluide a base d'un complexe metallique et son procede de preparation.
US5516808A (en) * 1994-10-27 1996-05-14 Sawaya; Assad S. Topical cellulose pharmaceutical formulation
US5686095A (en) * 1995-10-23 1997-11-11 Price, Jr.; Francis W. Method of treating canker sores
US5888493A (en) * 1996-12-05 1999-03-30 Sawaya; Assad S. Ophthalmic aqueous gel formulation and related methods
DE19729879C2 (de) * 1997-07-11 1999-07-08 Mann Gerhard Chem Pharm Fab Lagerstabile ophthalmische Zusammensetzungen, umfassend Diclofenac und Ofloxacin
US6861411B1 (en) 1997-12-02 2005-03-01 Pfizer, Inc. Method of treating eye infections with azithromycin
US6017912A (en) * 1998-02-27 2000-01-25 Bussell; Letantia Topical fluoroquinolone antibiotics in an alcohol and acetone vehicle
US5912255A (en) * 1998-02-27 1999-06-15 Bussell; Letantia Topical fluoroquinolone antibiotics combined with benzoyl peroxide
US6395746B1 (en) 1998-09-30 2002-05-28 Alcon Manufacturing, Ltd. Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
CA2344050A1 (en) * 1998-09-30 2000-04-06 Alcon Laboratories, Inc. Antibiotic compositions for treatment of the eye, ear and nose
US6509327B1 (en) 1998-09-30 2003-01-21 Alcon Manufacturing, Ltd. Compositions and methods for treating otic, ophthalmic and nasal infections
US6716830B2 (en) * 1998-09-30 2004-04-06 Alcon, Inc. Ophthalmic antibiotic compositions containing moxifloxacin
US6685958B2 (en) 2001-04-25 2004-02-03 Insite Vision Incorporated Quinolone carboxylic acid compositions and related methods of treatment
US7056893B2 (en) * 1999-03-31 2006-06-06 Insite Vision, Inc. Topical treatment for prevention of ocular infections
US6239113B1 (en) * 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
US6699492B2 (en) * 1999-03-31 2004-03-02 Insite Vision Incorporated Quinolone carboxylic acid compositions and related methods of treatment
KR20000067454A (ko) * 1999-04-28 2000-11-15 김충섭 가교형태의 실록산그룹함유 고분자분리막
US6552020B1 (en) 1999-07-30 2003-04-22 Allergan, Inc. Compositions including antibiotics and methods for using same
US6166012A (en) * 1999-07-30 2000-12-26 Allergan Sales, Inc. Antibiotic compositions and method for using same
JP2002037746A (ja) * 2000-07-24 2002-02-06 Fuji Yakuhin:Kk キノロンカルボン酸系抗菌剤を含有する液剤
US7943585B2 (en) * 2003-12-22 2011-05-17 Sandoz, Inc. Extended release antibiotic composition
US20060046970A1 (en) * 2004-08-31 2006-03-02 Insite Vision Incorporated Topical otic compositions and methods of topical treatment of prevention of otic infections
DE102006010643A1 (de) * 2006-03-08 2007-09-13 Bayer Healthcare Aktiengesellschaft Arzneimittel enthaltend Fluorchinolone
CA2680831A1 (en) * 2007-03-14 2008-09-18 University Of Washington Device and method for intraocular drug delivery
ES2588437T3 (es) * 2007-11-30 2016-11-02 Toltec Pharmaceuticals, Llc Composiciones y métodos para tratar infecciones vaginales y biopelículas vaginales patógenas
CA2723954A1 (en) * 2008-05-19 2009-11-26 Alcon Research, Ltd. Pharmaceutical compositions having carboxyvinyl polymer and povidone polymer
CN105534886A (zh) * 2015-12-31 2016-05-04 湖北远大天天明制药有限公司 一种诺氟沙星滴眼剂及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53141286A (en) * 1977-05-16 1978-12-08 Kyorin Seiyaku Kk Novel substituted quinolinecarboxylic acid
GB1598915A (en) * 1977-09-20 1981-09-23 Bellon Labor Sa Roger 1,4-dihydro-quinoline-3-carboxylic acid derivatives process for their preparation and composition containing them
CA1175836A (en) * 1977-09-20 1984-10-09 Marcel Pesson Production of 1,4-dihydroquinoline-3-carboxylic acid derivatives
AR223983A1 (es) * 1978-08-25 1981-10-15 Dainippon Pharmaceutical Co Un procedimiento para-preparar derivados de acido 6-halogeno-4-oxo-7-(1-piperazinil)-1,8-naftiridin-3-carboxilico
JPS5746986A (en) * 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
DE3142854A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3033157A1 (de) * 1980-09-03 1982-04-01 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
IE52125B1 (en) * 1980-10-02 1987-06-24 Fox Charles L Jun 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quino-line carboxylic acid and metal salts thereof useful in burn therapy

Also Published As

Publication number Publication date
IL73426A (en) 1989-03-31
ES537584A0 (es) 1986-01-16
NZ210104A (en) 1988-03-30
EP0142426A3 (en) 1986-12-17
EP0142426A2 (en) 1985-05-22
US4551456A (en) 1985-11-05
ZA848829B (en) 1986-06-25
PT79454A (en) 1984-12-01
GR80874B (en) 1985-03-07
PT79454B (en) 1986-12-11
AU567979B2 (en) 1987-12-10
AU3538084A (en) 1985-05-23
DK537784D0 (da) 1984-11-13
JPS60123420A (ja) 1985-07-02
IL73426A0 (en) 1985-02-28
DK537784A (da) 1985-05-15
CA1241599A (en) 1988-09-06

Similar Documents

Publication Publication Date Title
ES8604018A1 (es) Un procedimiento para la preparacion de injertos oftalmicos solidos.
AU554213B2 (en) High and low temperature packer
NO179274C (no) Anvendelse av glassaktig amylose som en bærer ved fremstilling av en blanding for oral administrasjon
AU564675B2 (en) Poly(dihydrobenzoxazine) derivatives
AU2679684A (en) Naphthoquinone derivatives
AU1322283A (en) Asporogenic mutant of bacillus subtilis as host in host-vector system
AU582124B2 (en) Cyclohexenol derivatives and their use for controlling undersirable plant growth
AU555879B2 (en) Dummy (baby comforter)
AU7107387A (en) High speed thermomagnetic tape duplication
HUT34017A (en) Process for preparing pyrimidine derivatives
AU511923B2 (en) Thermal treatment of glass
AU573663B2 (en) Acylated benzoxazine and benzthiazine derivatives
AU552963B2 (en) Thermally toughening glass
JO1490B1 (en) Innovative vehicles
AU568882B2 (en) Microbial enzymatic contact lens cleaner and method of use
AU524573B2 (en) Thermal toughening of glass
AU5763480A (en) Nutrient medium
AU7542487A (en) Ignition transfer medium
AU7018281A (en) Regenerator amplifier supply
AU563638B2 (en) Parison transfer
DE3370652D1 (en) Bacillus subtilis dsm 2704 and process for the preparation of alpha-amylase
AU555542B2 (en) Asporogenic mutant of bacillus subtilis as host in host-vector system
AU92546S (en) Hot air oven
AU520281B2 (en) Thermal toughening of glass
AU2842684A (en) Parison transfer

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20051107