ES8603855A1 - Procedimiento de preparacion de nuevos derivados benzohi- drilpiperacinos y sus sales de adicion acidas - Google Patents
Procedimiento de preparacion de nuevos derivados benzohi- drilpiperacinos y sus sales de adicion acidasInfo
- Publication number
- ES8603855A1 ES8603855A1 ES543797A ES543797A ES8603855A1 ES 8603855 A1 ES8603855 A1 ES 8603855A1 ES 543797 A ES543797 A ES 543797A ES 543797 A ES543797 A ES 543797A ES 8603855 A1 ES8603855 A1 ES 8603855A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- pharmaceutical compositions
- compositions containing
- benzhydrylpiperazine
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
Abstract
PROCEDIMIENTO DE PREPARACION DE NUEVOS DERIVADOS BENZOHIDRILPIPERACINOS Y SUS SALES DE ADICION ACIDAS. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) EN EL QUE X ES HALOGENO CON 1-BENZOHIDRIL-PIPERACINA EN PRESENCIA DE UN AGENTE AGLUTINANTE DE ACIDOS, PARA OBTENER DERIVADOS BENZOIDRILPIPERACINOS Y SUS SALES DE ADICION DE ACIDOS DE FORMULA (I) DONDE N ES 2 O 3. LA REACCION SE EFECTUA EN UN DISOLVENTE ORGANICO, EN PRESENCIA DE UNA BASE ADECUADA PARA AGLUTINAR EL ACIDO FORMADO EN LA REACCION, EMPLEANDOSE COMO DISOLVENTES HIDROCARBUROS TALES COMO LIGROINA, BENCENO, TOLUENO Y OTROS, O MEZCLAS DE ESTOS; LLEVANDOSE A CABO LA REACCION A UNA TEMPERATURA ENTRE 20JC Y LA DEL PUNTO DE EBULLICION DEL DISOLVENTE EMPLEADO. TIENEN PROPIEDADES FARMACEUTICAS POR INHIBIR EL SISTEMA ENZIMATICO DE LAS MONOOXIGENASAS MICROSOMATICAS DEL HIGADO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU824187A HU186656B (en) | 1982-12-28 | 1982-12-28 | Process for producing new benzhydryl-piperazine derivatives, acid additionak salts and pharmaceutical compositions containing them |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8603855A1 true ES8603855A1 (es) | 1986-01-01 |
ES543797A0 ES543797A0 (es) | 1986-01-01 |
Family
ID=10967254
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES528457A Granted ES528457A0 (es) | 1982-12-28 | 1983-12-27 | Procedimiento de preparacion de nuevos derivados benzohidrilpiperacinos y sus sales de adicion acidas |
ES543797A Granted ES543797A0 (es) | 1982-12-28 | 1985-06-01 | Procedimiento de preparacion de nuevos derivados benzohi- drilpiperacinos y sus sales de adicion acidas |
ES543796A Granted ES543796A0 (es) | 1982-12-28 | 1985-06-01 | Procedimiento de preparacion de nuevos derivados benzohi- drilpiperacinos y sus sales de adicion acidas |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES528457A Granted ES528457A0 (es) | 1982-12-28 | 1983-12-27 | Procedimiento de preparacion de nuevos derivados benzohidrilpiperacinos y sus sales de adicion acidas |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES543796A Granted ES543796A0 (es) | 1982-12-28 | 1985-06-01 | Procedimiento de preparacion de nuevos derivados benzohi- drilpiperacinos y sus sales de adicion acidas |
Country Status (14)
Country | Link |
---|---|
US (1) | US4504481A (es) |
EP (1) | EP0115203B1 (es) |
JP (1) | JPS59134785A (es) |
AT (1) | ATE26271T1 (es) |
AU (1) | AU556474B2 (es) |
CA (1) | CA1215060A (es) |
DE (1) | DE3370625D1 (es) |
DK (1) | DK160495C (es) |
ES (3) | ES528457A0 (es) |
FI (1) | FI78912C (es) |
GR (1) | GR79152B (es) |
HU (1) | HU186656B (es) |
IL (1) | IL70556A (es) |
ZA (1) | ZA839618B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990013539A1 (en) * | 1989-04-28 | 1990-11-15 | Meiji Seika Kaisha, Ltd. | New n-substituted piperazine derivatives and drug for improving functional disorder of brain |
JP2679872B2 (ja) * | 1989-04-28 | 1997-11-19 | 明治製菓株式会社 | N−置換ピペラジン誘導体を含む脳機能障害改善剤 |
GB0816783D0 (en) | 2008-09-15 | 2008-10-22 | Carmeda Ab | Immobilised biological entities |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3075014A (en) * | 1960-06-14 | 1963-01-22 | Richardson Merrell Inc | Basic substituted alkoxy diphenylalkanols, diphenylalkenes and diphenylalkanes |
NL7306771A (es) * | 1972-06-02 | 1973-12-04 | ||
JPS5226822B2 (es) * | 1973-05-31 | 1977-07-16 | ||
HU168432B (es) * | 1973-08-15 | 1976-04-28 | ||
GB1491207A (en) * | 1973-11-12 | 1977-11-09 | Atomic Energy Authority Uk | Sensors for monitoring the electrical conductivity of electrically conductive fluids |
JPS606946B2 (ja) * | 1974-03-12 | 1985-02-21 | 東京田辺製薬株式会社 | N−(3,3−ジフエニルプロピル)−n’−アラルキル置換ピペラジンおよびその塩の製法 |
US3998815A (en) * | 1974-06-24 | 1976-12-21 | Interx Research Corporation | 1-hydrocarbonoyloxymethyl-3-carbamoyl or 3-carboethoxy-pyridinium salts |
-
1982
- 1982-12-28 HU HU824187A patent/HU186656B/hu not_active IP Right Cessation
-
1983
- 1983-12-23 AT AT83307966T patent/ATE26271T1/de not_active IP Right Cessation
- 1983-12-23 CA CA000444190A patent/CA1215060A/en not_active Expired
- 1983-12-23 DE DE8383307966T patent/DE3370625D1/de not_active Expired
- 1983-12-23 AU AU22910/83A patent/AU556474B2/en not_active Ceased
- 1983-12-23 EP EP83307966A patent/EP0115203B1/en not_active Expired
- 1983-12-27 FI FI834795A patent/FI78912C/fi not_active IP Right Cessation
- 1983-12-27 ES ES528457A patent/ES528457A0/es active Granted
- 1983-12-27 DK DK601483A patent/DK160495C/da not_active IP Right Cessation
- 1983-12-27 ZA ZA839618A patent/ZA839618B/xx unknown
- 1983-12-27 JP JP58244947A patent/JPS59134785A/ja active Granted
- 1983-12-27 IL IL70556A patent/IL70556A/xx unknown
- 1983-12-27 US US06/565,923 patent/US4504481A/en not_active Expired - Fee Related
- 1983-12-28 GR GR73366A patent/GR79152B/el unknown
-
1985
- 1985-06-01 ES ES543797A patent/ES543797A0/es active Granted
- 1985-06-01 ES ES543796A patent/ES543796A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
FI78912C (fi) | 1989-10-10 |
FI78912B (fi) | 1989-06-30 |
DK601483D0 (da) | 1983-12-27 |
ZA839618B (en) | 1984-08-29 |
CA1215060A (en) | 1986-12-09 |
AU2291083A (en) | 1984-07-05 |
IL70556A (en) | 1986-12-31 |
JPH0348907B2 (es) | 1991-07-25 |
ES8601175A1 (es) | 1985-11-01 |
JPS59134785A (ja) | 1984-08-02 |
DE3370625D1 (en) | 1987-05-07 |
DK160495C (da) | 1991-09-16 |
HU186656B (en) | 1985-09-30 |
ES8603854A1 (es) | 1986-01-01 |
DK160495B (da) | 1991-03-18 |
US4504481A (en) | 1985-03-12 |
ES543797A0 (es) | 1986-01-01 |
FI834795A0 (fi) | 1983-12-27 |
GR79152B (es) | 1984-10-02 |
FI834795A (fi) | 1984-06-29 |
IL70556A0 (en) | 1984-03-30 |
ATE26271T1 (de) | 1987-04-15 |
EP0115203A1 (en) | 1984-08-08 |
ES543796A0 (es) | 1986-01-01 |
EP0115203B1 (en) | 1987-04-01 |
ES528457A0 (es) | 1985-11-01 |
DK601483A (da) | 1984-06-29 |
AU556474B2 (en) | 1986-11-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970401 |