ES8601175A1 - Procedimiento de preparacion de nuevos derivados benzohidrilpiperacinos y sus sales de adicion acidas - Google Patents

Procedimiento de preparacion de nuevos derivados benzohidrilpiperacinos y sus sales de adicion acidas

Info

Publication number
ES8601175A1
ES8601175A1 ES528457A ES528457A ES8601175A1 ES 8601175 A1 ES8601175 A1 ES 8601175A1 ES 528457 A ES528457 A ES 528457A ES 528457 A ES528457 A ES 528457A ES 8601175 A1 ES8601175 A1 ES 8601175A1
Authority
ES
Spain
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
benzhydrylpiperazine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES528457A
Other languages
English (en)
Other versions
ES528457A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of ES8601175A1 publication Critical patent/ES8601175A1/es
Publication of ES528457A0 publication Critical patent/ES528457A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS BENZOHIDRILPIPERACINOS Y SUS SALES DE ADICION ACIDAS DE FORMULA GENERAL (I) EN LA QUE N ES 2 O 3. CONSISTE EN HACER REACCIONAR UNA PROPIOFENONA DE FORMULA GENERAL (II) EN LA QUE N TIENE EL SIGNIFICADO YA MENCIONADO CON UN COMPUESTO ORGANOMETALICO DE FORMULA GENERAL (III) EN LA QUE M ES UN METAL ALCALINO PREFERENTEMENTE LITIO SODIO O POTASIO O UN GRUPO MGX EN EL QUE X ES HALOGENO. LOS COMPUESTOS OBTENIDOS SE PUEDEN CONVERTIR EN SALES MEDIANTE LA ADICION DE LOS ACIDOS CORRESPONDIENTES. DE APLICACION EN TERAPIA PARA INHIBIR O REDUCIR EL EFECTO TOXICO DE SUSTANCIAS XENOBIOTICAS.
ES528457A 1982-12-28 1983-12-27 Procedimiento de preparacion de nuevos derivados benzohidrilpiperacinos y sus sales de adicion acidas Granted ES528457A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU824187A HU186656B (en) 1982-12-28 1982-12-28 Process for producing new benzhydryl-piperazine derivatives, acid additionak salts and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
ES8601175A1 true ES8601175A1 (es) 1985-11-01
ES528457A0 ES528457A0 (es) 1985-11-01

Family

ID=10967254

Family Applications (3)

Application Number Title Priority Date Filing Date
ES528457A Granted ES528457A0 (es) 1982-12-28 1983-12-27 Procedimiento de preparacion de nuevos derivados benzohidrilpiperacinos y sus sales de adicion acidas
ES543796A Granted ES543796A0 (es) 1982-12-28 1985-06-01 Procedimiento de preparacion de nuevos derivados benzohi- drilpiperacinos y sus sales de adicion acidas
ES543797A Granted ES543797A0 (es) 1982-12-28 1985-06-01 Procedimiento de preparacion de nuevos derivados benzohi- drilpiperacinos y sus sales de adicion acidas

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES543796A Granted ES543796A0 (es) 1982-12-28 1985-06-01 Procedimiento de preparacion de nuevos derivados benzohi- drilpiperacinos y sus sales de adicion acidas
ES543797A Granted ES543797A0 (es) 1982-12-28 1985-06-01 Procedimiento de preparacion de nuevos derivados benzohi- drilpiperacinos y sus sales de adicion acidas

Country Status (14)

Country Link
US (1) US4504481A (es)
EP (1) EP0115203B1 (es)
JP (1) JPS59134785A (es)
AT (1) ATE26271T1 (es)
AU (1) AU556474B2 (es)
CA (1) CA1215060A (es)
DE (1) DE3370625D1 (es)
DK (1) DK160495C (es)
ES (3) ES528457A0 (es)
FI (1) FI78912C (es)
GR (1) GR79152B (es)
HU (1) HU186656B (es)
IL (1) IL70556A (es)
ZA (1) ZA839618B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2679872B2 (ja) * 1989-04-28 1997-11-19 明治製菓株式会社 Ｎ−置換ピペラジン誘導体を含む脳機能障害改善剤
WO1990013539A1 (en) * 1989-04-28 1990-11-15 Meiji Seika Kaisha, Ltd. New n-substituted piperazine derivatives and drug for improving functional disorder of brain
GB0816783D0 (en) 2008-09-15 2008-10-22 Carmeda Ab Immobilised biological entities

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3075014A (en) * 1960-06-14 1963-01-22 Richardson Merrell Inc Basic substituted alkoxy diphenylalkanols, diphenylalkenes and diphenylalkanes
NL7306771A (es) * 1972-06-02 1973-12-04
JPS5226822B2 (es) * 1973-05-31 1977-07-16
HU168432B (es) * 1973-08-15 1976-04-28
GB1491207A (en) * 1973-11-12 1977-11-09 Atomic Energy Authority Uk Sensors for monitoring the electrical conductivity of electrically conductive fluids
JPS606946B2 (ja) * 1974-03-12 1985-02-21 東京田辺製薬株式会社 Ｎ−（３，３−ジフエニルプロピル）−ｎ’−アラルキル置換ピペラジンおよびその塩の製法
US3998815A (en) * 1974-06-24 1976-12-21 Interx Research Corporation 1-hydrocarbonoyloxymethyl-3-carbamoyl or 3-carboethoxy-pyridinium salts

Also Published As

Publication number Publication date
ES8603855A1 (es) 1986-01-01
AU556474B2 (en) 1986-11-06
AU2291083A (en) 1984-07-05
FI78912B (fi) 1989-06-30
IL70556A (en) 1986-12-31
DE3370625D1 (en) 1987-05-07
IL70556A0 (en) 1984-03-30
US4504481A (en) 1985-03-12
CA1215060A (en) 1986-12-09
ATE26271T1 (de) 1987-04-15
GR79152B (es) 1984-10-02
ES8603854A1 (es) 1986-01-01
FI834795A (fi) 1984-06-29
DK601483A (da) 1984-06-29
HU186656B (en) 1985-09-30
JPH0348907B2 (es) 1991-07-25
EP0115203B1 (en) 1987-04-01
DK160495B (da) 1991-03-18
EP0115203A1 (en) 1984-08-08
ZA839618B (en) 1984-08-29
ES543796A0 (es) 1986-01-01
JPS59134785A (ja) 1984-08-02
DK601483D0 (da) 1983-12-27
DK160495C (da) 1991-09-16
ES543797A0 (es) 1986-01-01
FI834795A0 (fi) 1983-12-27
ES528457A0 (es) 1985-11-01
FI78912C (fi) 1989-10-10

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303