ES8603822A1 - Un procedimiento para la preparacion de un indol - Google Patents

Un procedimiento para la preparacion de un indol

Info

Publication number
ES8603822A1
ES8603822A1 ES538335A ES538335A ES8603822A1 ES 8603822 A1 ES8603822 A1 ES 8603822A1 ES 538335 A ES538335 A ES 538335A ES 538335 A ES538335 A ES 538335A ES 8603822 A1 ES8603822 A1 ES 8603822A1
Authority
ES
Spain
Prior art keywords
alkyl
group
production
indole
alkenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES538335A
Other languages
English (en)
Other versions
ES538335A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES8603822A1 publication Critical patent/ES8603822A1/es
Publication of ES538335A0 publication Critical patent/ES538335A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UN INDOL. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN PRESENCIA DE UNA BASE TAL COMO UN CARBONATO O BICARBONATO DE UN METAL ALCALINO, UNA AMINA TERCIARIA, UN ALCOXIDO O UN HIDRURO, EN UN DISOLVENTE ORGANICO, TALES COMO ETERES, AMIDAS, ALCOHOLES, Y OTROS, A UNA TEMPERATURA ENTRE C20J Y 150JC, PARA OBTENER UN COMPUESTO DE FORMULA (I). SIENDO: ALQ, UNA CADENA ALQUILENICA DE C 2 A 3; R1, H O UN GRUPO ALQUILO DE C 1 A 6 O ALQUENILO DE C 3 A 6; R2, H O UN GRUPO ALQUILO DE C 1 A 3, ALQUENILO DE C 3 A 6, ARILO, AR-ALQUILO DE C 1 A 4 O CICLOALQUILO DE C 5 A 7; R3, H O UN GRUPO ALQUILO DE C 1 A 3; R4 A R5, H O UN GRUPO ALQUILO DE C 1 A 3 O PROPENILO. SE UTILIZA EN EL TRATAMIENTO DE LA JAQUECA.
ES538335A 1983-12-06 1984-12-06 Un procedimiento para la preparacion de un indol Granted ES538335A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838332434A GB8332434D0 (en) 1983-12-06 1983-12-06 Production of chemical compounds

Publications (2)

Publication Number Publication Date
ES8603822A1 true ES8603822A1 (es) 1986-01-01
ES538335A0 ES538335A0 (es) 1986-01-01

Family

ID=10552844

Family Applications (1)

Application Number Title Priority Date Filing Date
ES538335A Granted ES538335A0 (es) 1983-12-06 1984-12-06 Un procedimiento para la preparacion de un indol

Country Status (7)

Country Link
EP (1) EP0145459A3 (es)
JP (1) JPS60139669A (es)
KR (1) KR920000895B1 (es)
CA (1) CA1230602A (es)
ES (1) ES538335A0 (es)
FI (1) FI79699C (es)
GB (1) GB8332434D0 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
US4833153A (en) * 1985-11-08 1989-05-23 Glaxo Group Limited Indole derivatives
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8601959D0 (en) * 1986-01-28 1986-03-05 Glaxo Group Ltd Indole derivatives
US5270333A (en) * 1986-01-28 1993-12-14 Glaxo Group Limited Indole derivatives
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
ES2033578B1 (es) * 1991-06-06 1995-01-16 Quimica Sint S A Con El 50 Procedimiento para la obtencion de 3-(2-(dimetilamino)etil)-n-metil-1h-indol-5-metanosulfonamida.
ES2055651B1 (es) * 1992-07-20 1995-03-01 Vita Invest Sa Procedimiento para la obtencion de nuevas amidinas derivadas de 3-aminoetilindoles.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3472870A (en) * 1966-08-29 1969-10-14 Mead Johnson & Co Sulfonamidotryptamines
ZW19381A1 (en) * 1980-08-12 1983-03-09 Glaxo Group Ltd Heterocyclic compounds
GR79215B (es) * 1982-06-07 1984-10-22 Glaxo Group Ltd

Also Published As

Publication number Publication date
GB8332434D0 (en) 1984-01-11
JPS60139669A (ja) 1985-07-24
FI79699C (fi) 1990-02-12
KR920000895B1 (ko) 1992-01-30
CA1230602A (en) 1987-12-22
FI844788L (fi) 1985-06-07
FI844788A0 (fi) 1984-12-05
FI79699B (fi) 1989-10-31
EP0145459A3 (en) 1985-07-10
ES538335A0 (es) 1986-01-01
KR850004460A (ko) 1985-07-15
EP0145459A2 (en) 1985-06-19

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20050920