JPS5663945A - Preparation of novel alkanolamine derivative - Google Patents

Preparation of novel alkanolamine derivative

Info

Publication number
JPS5663945A
JPS5663945A JP13868479A JP13868479A JPS5663945A JP S5663945 A JPS5663945 A JP S5663945A JP 13868479 A JP13868479 A JP 13868479A JP 13868479 A JP13868479 A JP 13868479A JP S5663945 A JPS5663945 A JP S5663945A
Authority
JP
Japan
Prior art keywords
formula
compound
reacting
alkanolamine derivative
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP13868479A
Other languages
Japanese (ja)
Inventor
Nobunori Takemoto
Tokuyuki Kuroda
Yoshihiro Nakamizo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP13868479A priority Critical patent/JPS5663945A/en
Publication of JPS5663945A publication Critical patent/JPS5663945A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain the titled compound which is a β-blocking agent having an antiarrhythmic and hypotensive actions industrially and advantageously, by reacting a formimidate compound with a glycidyl compound as raw materials, and deformylating the reaction product.
CONSTITUTION: A compound of formula I (R is 1W6C chain or alicyclic alkyl; X is O or NH; R' is 1W4C alkyl) is reacted with a compound of formula II (Ar is naphthyl or indolyl) to give a novel compound of formula III, which is then deformylated to afford an alkanolamine derivative of formula IV, e.g. N-isopropyl-N-[2- hydroxy-3-(4-indoloxy)]propylformamide. According to the method, side reactions will scarcely occur, and purification is readily carried out in high yield. The com?pound of formula I is obtained by reacting an amine of the formula R-NH2 with an orthoformate of the formula (R'O)3CH by the well-known method.
COPYRIGHT: (C)1981,JPO&Japio
JP13868479A 1979-10-29 1979-10-29 Preparation of novel alkanolamine derivative Pending JPS5663945A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13868479A JPS5663945A (en) 1979-10-29 1979-10-29 Preparation of novel alkanolamine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13868479A JPS5663945A (en) 1979-10-29 1979-10-29 Preparation of novel alkanolamine derivative

Publications (1)

Publication Number Publication Date
JPS5663945A true JPS5663945A (en) 1981-05-30

Family

ID=15227682

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13868479A Pending JPS5663945A (en) 1979-10-29 1979-10-29 Preparation of novel alkanolamine derivative

Country Status (1)

Country Link
JP (1) JPS5663945A (en)

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