JPS5663945A - Preparation of novel alkanolamine derivative - Google Patents
Preparation of novel alkanolamine derivativeInfo
- Publication number
- JPS5663945A JPS5663945A JP13868479A JP13868479A JPS5663945A JP S5663945 A JPS5663945 A JP S5663945A JP 13868479 A JP13868479 A JP 13868479A JP 13868479 A JP13868479 A JP 13868479A JP S5663945 A JPS5663945 A JP S5663945A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- reacting
- alkanolamine derivative
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the titled compound which is a β-blocking agent having an antiarrhythmic and hypotensive actions industrially and advantageously, by reacting a formimidate compound with a glycidyl compound as raw materials, and deformylating the reaction product.
CONSTITUTION: A compound of formula I (R is 1W6C chain or alicyclic alkyl; X is O or NH; R' is 1W4C alkyl) is reacted with a compound of formula II (Ar is naphthyl or indolyl) to give a novel compound of formula III, which is then deformylated to afford an alkanolamine derivative of formula IV, e.g. N-isopropyl-N-[2- hydroxy-3-(4-indoloxy)]propylformamide. According to the method, side reactions will scarcely occur, and purification is readily carried out in high yield. The com?pound of formula I is obtained by reacting an amine of the formula R-NH2 with an orthoformate of the formula (R'O)3CH by the well-known method.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13868479A JPS5663945A (en) | 1979-10-29 | 1979-10-29 | Preparation of novel alkanolamine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13868479A JPS5663945A (en) | 1979-10-29 | 1979-10-29 | Preparation of novel alkanolamine derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5663945A true JPS5663945A (en) | 1981-05-30 |
Family
ID=15227682
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13868479A Pending JPS5663945A (en) | 1979-10-29 | 1979-10-29 | Preparation of novel alkanolamine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5663945A (en) |
-
1979
- 1979-10-29 JP JP13868479A patent/JPS5663945A/en active Pending
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