JPS56147780A - 3-allyl-5-hydroxymethyltetrahydrofuran-2-ones - Google Patents

3-allyl-5-hydroxymethyltetrahydrofuran-2-ones

Info

Publication number
JPS56147780A
JPS56147780A JP5074380A JP5074380A JPS56147780A JP S56147780 A JPS56147780 A JP S56147780A JP 5074380 A JP5074380 A JP 5074380A JP 5074380 A JP5074380 A JP 5074380A JP S56147780 A JPS56147780 A JP S56147780A
Authority
JP
Japan
Prior art keywords
formula
hydroxymethyltetrahydrofuran
allyl
compound shown
give
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5074380A
Other languages
Japanese (ja)
Other versions
JPH0115510B2 (en
Inventor
Seiichi Takano
Kuniro Ogasawara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kawaken Fine Chemicals Co Ltd
Original Assignee
Kawaken Fine Chemicals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kawaken Fine Chemicals Co Ltd filed Critical Kawaken Fine Chemicals Co Ltd
Priority to JP5074380A priority Critical patent/JPS56147780A/en
Publication of JPS56147780A publication Critical patent/JPS56147780A/en
Publication of JPH0115510B2 publication Critical patent/JPH0115510B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Furan Compounds (AREA)

Abstract

NEW MATERIAL:3-Allyl-5- hydroxymethyltetrahydrofuran-2- ones shown by the formula I (R1 and R2 are H or 1W4C alkyl; R3 is H or OH-protecting group).
EXAMPLE: (3R, 5S)-3-Allyl-3-ethyl-5-hydroxymethyltetrahydrofuran-2-one.
USE: A raw material for a nontryptamine part of the precursor of a physiologically active indolealkaloid(hypotensive, cerebrovascular vasodilator, antitumor agent). The raw material is industrially advantageous.
PROCESS: For example, 5-hydroxymethyltetrahydrofuran-2-one shown by the formula II obtained from glutamic acid is reacted with a compound shown by the formula R'3X (R' is OH-protecting group; X is halogen), to give a compound shown by the formula III, which is reacted with an ally halide in the presence of a base, e.g., lithium isopropylamide to give a compound shown by the formula IV. This compound is alkylated with an alkyl halide, to give a compound shown by the formula I wherein R3 is R3'.
COPYRIGHT: (C)1981,JPO&Japio
JP5074380A 1980-04-17 1980-04-17 3-allyl-5-hydroxymethyltetrahydrofuran-2-ones Granted JPS56147780A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5074380A JPS56147780A (en) 1980-04-17 1980-04-17 3-allyl-5-hydroxymethyltetrahydrofuran-2-ones

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5074380A JPS56147780A (en) 1980-04-17 1980-04-17 3-allyl-5-hydroxymethyltetrahydrofuran-2-ones

Publications (2)

Publication Number Publication Date
JPS56147780A true JPS56147780A (en) 1981-11-16
JPH0115510B2 JPH0115510B2 (en) 1989-03-17

Family

ID=12867313

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5074380A Granted JPS56147780A (en) 1980-04-17 1980-04-17 3-allyl-5-hydroxymethyltetrahydrofuran-2-ones

Country Status (1)

Country Link
JP (1) JPS56147780A (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56150078A (en) * 1979-12-22 1981-11-20 Dynamit Nobel Ag Substituted lactone, its manufacture and pentanecarboxylic acid derivative

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56150078A (en) * 1979-12-22 1981-11-20 Dynamit Nobel Ag Substituted lactone, its manufacture and pentanecarboxylic acid derivative

Also Published As

Publication number Publication date
JPH0115510B2 (en) 1989-03-17

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