ES8603186A1 - Procedimiento para preparar 9-(propoximetil monosubstituido en 1-0 o en 3-0 o di-substituido en 1,3-0)-purinas substi- tuido en 1,3-0)-purinas substituidas como agentes antivira- les - Google Patents

Procedimiento para preparar 9-(propoximetil monosubstituido en 1-0 o en 3-0 o di-substituido en 1,3-0)-purinas substi- tuido en 1,3-0)-purinas substituidas como agentes antivira- les

Info

Publication number
ES8603186A1
ES8603186A1 ES545261A ES545261A ES8603186A1 ES 8603186 A1 ES8603186 A1 ES 8603186A1 ES 545261 A ES545261 A ES 545261A ES 545261 A ES545261 A ES 545261A ES 8603186 A1 ES8603186 A1 ES 8603186A1
Authority
ES
Spain
Prior art keywords
virus
herpes
carbon atoms
nr9r10
azido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES545261A
Other languages
English (en)
Other versions
ES545261A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of ES8603186A1 publication Critical patent/ES8603186A1/es
Publication of ES545261A0 publication Critical patent/ES545261A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/17—Unsaturated ethers containing halogen
    • C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
    • C07C43/1745—Unsaturated ethers containing halogen containing six-membered aromatic rings having more than one ether bound
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
    • C07C43/1785—Unsaturated ethers containing hydroxy or O-metal groups having more than one ether bound
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR 9-(PROPOXIMETIL MONOSUSTITUIDO EN 1-O O EN 3-O O DISUSTITUIDO EN 1,3-O)-PURINAS COMO AGENTES ANTIVIRALES. CONSISTENTE EN: A) HACER REACCIONAR COMPUESTOS DE FORMULA (XV) CON R7NH2, CON 4-DIMETILAMINOPIRIDINA COMO CATALIZADOR, CALENTANDO A 50-200JC DURANTE 12 A 48 HORAS, PARA OBTENER COMPUESTOS DE FORMULA (I); Y B) AISLAR A (I) POR CROMATOGRAFIA. SIENDO: R1 F H, ALQUENILO DE 2 A 12 C, CICLOPENTILO Y OTROS; R2 ES -C(O)NHR7 DONDE R7 ES UN ALCOHOLITO DE 1 A 12 C; R3 ES H, HALO, TIO, ALCOHILTIO INFERIOR DE 1 A 6 C Y OTROS; R4 Y R5 FORMAN UN ENLACE O R5 CON R6 SON UN GRUPO CETO Y R4 ES H; R6 ES H, HALO, ALCOXI INFERIOR DE 1 A 6 C Y OTROS; W ES H O 1-CARBONILIMIDAZOL; Y WA ES 1-CARBONIMIDAZOL. SE UTILIZAN POR SU POTENTE ACTIVIDAD ANTIVIRAL CONTRA VIRUS DE HERPES SIMPLEX I Y II Y OTROS VIRUS RELACIONADOS, CUANDO SE ADMINISTRAN A ANIMALES DE SANGRE CALIENTE O FRIA, Y EN ESPECIAL A SERES HUMANOS.
ES545261A 1982-08-09 1985-07-16 Procedimiento para preparar 9-(propoximetil monosubstituido en 1-0 o en 3-0 o di-substituido en 1,3-0)-purinas substi- tuido en 1,3-0)-purinas substituidas como agentes antivira- les Granted ES545261A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/406,583 US4556659A (en) 1982-08-09 1982-08-09 Substituted 9-(1-0- or 3-0-monosubstituted or 1,3-Di-0-substituted propoxymethyl)-purines as antiviral agents

Publications (2)

Publication Number Publication Date
ES8603186A1 true ES8603186A1 (es) 1986-01-01
ES545261A0 ES545261A0 (es) 1986-01-01

Family

ID=23608623

Family Applications (2)

Application Number Title Priority Date Filing Date
ES524811A Expired ES8603185A1 (es) 1982-08-09 1983-08-08 Procedimiento para preparar 9-(propoximetil monosubstituido en 1-0 o en 3-0 o di-substituido en 1,3-0)-purinas substituidas como agentes antivirales
ES545261A Granted ES545261A0 (es) 1982-08-09 1985-07-16 Procedimiento para preparar 9-(propoximetil monosubstituido en 1-0 o en 3-0 o di-substituido en 1,3-0)-purinas substi- tuido en 1,3-0)-purinas substituidas como agentes antivira- les

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES524811A Expired ES8603185A1 (es) 1982-08-09 1983-08-08 Procedimiento para preparar 9-(propoximetil monosubstituido en 1-0 o en 3-0 o di-substituido en 1,3-0)-purinas substituidas como agentes antivirales

Country Status (15)

Country Link
US (1) US4556659A (es)
EP (1) EP0105135B1 (es)
JP (1) JPS5948483A (es)
KR (1) KR890000811B1 (es)
AT (1) ATE25980T1 (es)
AU (1) AU571451B2 (es)
DE (1) DE3370331D1 (es)
DK (1) DK361383A (es)
ES (2) ES8603185A1 (es)
FI (1) FI74006C (es)
HU (1) HU193530B (es)
IE (1) IE55843B1 (es)
NO (1) NO162469C (es)
NZ (1) NZ205171A (es)
ZA (1) ZA835799B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816447A (en) * 1981-08-26 1989-03-28 Merck & Co., Inc. Anti-viral guanine compounds
US4609661A (en) * 1982-08-09 1986-09-02 Syntex (U.S.A.) Inc. Substituted 9-(1-O- or 3-O-monosubstituted or 1,3-di-O-substituted propoxymethyl)purines as antiviral agents
DE3376325D1 (en) * 1982-10-14 1988-05-26 Wellcome Found Antiviral purine derivatives
US4880820A (en) * 1983-06-24 1989-11-14 Merck & Co., Inc. Guanine derivatives
US4897479A (en) * 1983-09-30 1990-01-30 Merck & Co., Inc. Arylsulfonyloxy purine intermediates
SE8406538D0 (sv) * 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
US4642346A (en) * 1985-06-24 1987-02-10 Syntex (U.S.A.) Inc. Anhydrous crystalline 9-(1,3-dihydroxy-2-propoxymethyl)guanine
GB8904855D0 (en) * 1989-03-03 1989-04-12 Beecham Group Plc Pharmaceutical treatment
DE4002792A1 (de) * 1990-01-31 1991-08-01 Teves Gmbh Alfred Vorrichtung zur ermittlung der beschaffenheit einer druckuebertragungsfluessigkeit
GB2260319B (en) 1991-10-07 1995-12-06 Norsk Hydro As Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
CN110026212B (zh) * 2019-05-23 2022-03-04 临海市利民化工有限公司 一种裂解催化剂及使用该催化剂制备西他沙星中间体的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4199574A (en) * 1974-09-02 1980-04-22 Burroughs Wellcome Co. Methods and compositions for treating viral infections and guanine acyclic nucleosides
KR880002276B1 (ko) * 1981-08-11 1988-10-21 더 웰컴 화운데이션 리미티드 항비루스성 화합물의 제조방법
NZ201662A (en) * 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation

Also Published As

Publication number Publication date
HU193530B (en) 1987-10-28
AU571451B2 (en) 1988-04-21
ES524811A0 (es) 1986-01-01
IE831867L (en) 1984-02-09
EP0105135B1 (en) 1987-03-18
FI832832A0 (fi) 1983-08-08
ES545261A0 (es) 1986-01-01
KR890000811B1 (ko) 1989-04-08
DE3370331D1 (en) 1987-04-23
NO832842L (no) 1984-02-10
US4556659A (en) 1985-12-03
ATE25980T1 (de) 1987-04-15
NO162469C (no) 1990-01-10
JPS5948483A (ja) 1984-03-19
IE55843B1 (en) 1991-01-30
FI74006C (fi) 1987-12-10
DK361383D0 (da) 1983-08-08
ZA835799B (en) 1984-04-25
NO162469B (no) 1989-09-25
AU1768383A (en) 1984-02-16
FI832832A (fi) 1984-02-10
ES8603185A1 (es) 1986-01-01
EP0105135A1 (en) 1984-04-11
KR840006007A (ko) 1984-11-21
DK361383A (da) 1984-02-10
NZ205171A (en) 1987-05-29
FI74006B (fi) 1987-08-31

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