ES8603185A1 - Procedimiento para preparar 9-(propoximetil monosubstituido en 1-0 o en 3-0 o di-substituido en 1,3-0)-purinas substituidas como agentes antivirales - Google Patents

Procedimiento para preparar 9-(propoximetil monosubstituido en 1-0 o en 3-0 o di-substituido en 1,3-0)-purinas substituidas como agentes antivirales

Info

Publication number
ES8603185A1
ES8603185A1 ES524811A ES524811A ES8603185A1 ES 8603185 A1 ES8603185 A1 ES 8603185A1 ES 524811 A ES524811 A ES 524811A ES 524811 A ES524811 A ES 524811A ES 8603185 A1 ES8603185 A1 ES 8603185A1
Authority
ES
Spain
Prior art keywords
virus
herpes
carbon atoms
nr9r10
azido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES524811A
Other languages
English (en)
Other versions
ES524811A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of ES8603185A1 publication Critical patent/ES8603185A1/es
Publication of ES524811A0 publication Critical patent/ES524811A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/17—Unsaturated ethers containing halogen
    • C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
    • C07C43/1745—Unsaturated ethers containing halogen containing six-membered aromatic rings having more than one ether bound
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
    • C07C43/1785—Unsaturated ethers containing hydroxy or O-metal groups having more than one ether bound
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR 9-(PROPOXIMETIL MONOSUSTITUIDO EN 1-O O EN 3-O O DISUSTITUIDO EN 1,3-O)-PURINAS SUSTITUIDAS COMO AGENTES ANTIVIRALES. COMPRENDE: A) HACER REACCIONAR UN COMPUESTO DE FORMULA (II), CON R7OH EN UN DISOLVENTE, COMO N,N-DIMETILFORMAMIDA Y OTROS, A UNA TEMPERATURA DE 45 A 65JC, Y CON AGITACION; Y B) ELIMINAR EL DISOLVENTE Y HACER REACCIONAR EL COMPUESTO (II) CON UN ALCOHOL O AMINA EN PRESENCIA DE UN CATALIZADOR, COMO 4-DIMETILAMINOPIRIDINA A UNA TEMPERATURA DE 50 A 200JC, PARA OBTENER UN COMPUESTO DE FORMULA (I) POR CROMATOGRAFIA. SIENDO: R1 Y R2-C(-Y) OR7; R3 ES H, HALO Y OTROS; R4 Y R5 SON UN ENLACE; R6 ES H, HALO, ALCOXI INFERIOR CON C 1 A 6 Y OTROS; R7 ES ALCOHILO CON C 1 A 12, ALQUELINO CON C 2 A 12 Y OTROS; W ES H O 1-CARBONILIMIDAZOL; WA ES 1-CARBONILIMIDAZOL. SE UTILIZA COMO AGENTE ANTIVIRAL.
ES524811A 1982-08-09 1983-08-08 Procedimiento para preparar 9-(propoximetil monosubstituido en 1-0 o en 3-0 o di-substituido en 1,3-0)-purinas substituidas como agentes antivirales Granted ES524811A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/406,583 US4556659A (en) 1982-08-09 1982-08-09 Substituted 9-(1-0- or 3-0-monosubstituted or 1,3-Di-0-substituted propoxymethyl)-purines as antiviral agents

Publications (2)

Publication Number Publication Date
ES8603185A1 true ES8603185A1 (es) 1986-01-01
ES524811A0 ES524811A0 (es) 1986-01-01

Family

ID=23608623

Family Applications (2)

Application Number Title Priority Date Filing Date
ES524811A Granted ES524811A0 (es) 1982-08-09 1983-08-08 Procedimiento para preparar 9-(propoximetil monosubstituido en 1-0 o en 3-0 o di-substituido en 1,3-0)-purinas substituidas como agentes antivirales
ES545261A Expired ES8603186A1 (es) 1982-08-09 1985-07-16 Procedimiento para preparar 9-(propoximetil monosubstituido en 1-0 o en 3-0 o di-substituido en 1,3-0)-purinas substi- tuido en 1,3-0)-purinas substituidas como agentes antivira- les

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES545261A Expired ES8603186A1 (es) 1982-08-09 1985-07-16 Procedimiento para preparar 9-(propoximetil monosubstituido en 1-0 o en 3-0 o di-substituido en 1,3-0)-purinas substi- tuido en 1,3-0)-purinas substituidas como agentes antivira- les

Country Status (15)

Country Link
US (1) US4556659A (es)
EP (1) EP0105135B1 (es)
JP (1) JPS5948483A (es)
KR (1) KR890000811B1 (es)
AT (1) ATE25980T1 (es)
AU (1) AU571451B2 (es)
DE (1) DE3370331D1 (es)
DK (1) DK361383A (es)
ES (2) ES524811A0 (es)
FI (1) FI74006C (es)
HU (1) HU193530B (es)
IE (1) IE55843B1 (es)
NO (1) NO162469C (es)
NZ (1) NZ205171A (es)
ZA (1) ZA835799B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816447A (en) * 1981-08-26 1989-03-28 Merck & Co., Inc. Anti-viral guanine compounds
US4609661A (en) * 1982-08-09 1986-09-02 Syntex (U.S.A.) Inc. Substituted 9-(1-O- or 3-O-monosubstituted or 1,3-di-O-substituted propoxymethyl)purines as antiviral agents
ATE33653T1 (de) * 1982-10-14 1988-05-15 Wellcome Found Antivirale purinderivate.
US4880820A (en) * 1983-06-24 1989-11-14 Merck & Co., Inc. Guanine derivatives
US4897479A (en) * 1983-09-30 1990-01-30 Merck & Co., Inc. Arylsulfonyloxy purine intermediates
SE8406538D0 (sv) * 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
US4642346A (en) * 1985-06-24 1987-02-10 Syntex (U.S.A.) Inc. Anhydrous crystalline 9-(1,3-dihydroxy-2-propoxymethyl)guanine
GB8904855D0 (en) * 1989-03-03 1989-04-12 Beecham Group Plc Pharmaceutical treatment
DE4002792A1 (de) * 1990-01-31 1991-08-01 Teves Gmbh Alfred Vorrichtung zur ermittlung der beschaffenheit einer druckuebertragungsfluessigkeit
GB2260319B (en) 1991-10-07 1995-12-06 Norsk Hydro As Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
CN110026212B (zh) * 2019-05-23 2022-03-04 临海市利民化工有限公司 一种裂解催化剂及使用该催化剂制备西他沙星中间体的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4199574A (en) * 1974-09-02 1980-04-22 Burroughs Wellcome Co. Methods and compositions for treating viral infections and guanine acyclic nucleosides
AT380252B (de) * 1981-08-11 1986-05-12 Wellcome Found Verfahren zur herstellung von neuen guanin- und 2,6-diaminopurinderivaten und ihren salzen
NZ201662A (en) * 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation

Also Published As

Publication number Publication date
DE3370331D1 (en) 1987-04-23
AU1768383A (en) 1984-02-16
NZ205171A (en) 1987-05-29
FI74006B (fi) 1987-08-31
EP0105135A1 (en) 1984-04-11
KR840006007A (ko) 1984-11-21
EP0105135B1 (en) 1987-03-18
ES545261A0 (es) 1986-01-01
HU193530B (en) 1987-10-28
NO832842L (no) 1984-02-10
KR890000811B1 (ko) 1989-04-08
JPS5948483A (ja) 1984-03-19
AU571451B2 (en) 1988-04-21
FI832832A (fi) 1984-02-10
DK361383D0 (da) 1983-08-08
ZA835799B (en) 1984-04-25
FI74006C (fi) 1987-12-10
NO162469B (no) 1989-09-25
FI832832A0 (fi) 1983-08-08
DK361383A (da) 1984-02-10
IE831867L (en) 1984-02-09
ES524811A0 (es) 1986-01-01
NO162469C (no) 1990-01-10
ATE25980T1 (de) 1987-04-15
IE55843B1 (en) 1991-01-30
US4556659A (en) 1985-12-03
ES8603186A1 (es) 1986-01-01

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