ES8602723A1 - Un procedimiento para la preparacion de nuevas n-bencil-propilaminas sustituidas. - Google Patents

Un procedimiento para la preparacion de nuevas n-bencil-propilaminas sustituidas.

Info

Publication number
ES8602723A1
ES8602723A1 ES536264A ES536264A ES8602723A1 ES 8602723 A1 ES8602723 A1 ES 8602723A1 ES 536264 A ES536264 A ES 536264A ES 536264 A ES536264 A ES 536264A ES 8602723 A1 ES8602723 A1 ES 8602723A1
Authority
ES
Spain
Prior art keywords
benzylpropyl
pyrrolidino
isobutoxy
amines
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES536264A
Other languages
English (en)
Other versions
ES536264A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre Europeen de Recherches Mauvernay CERM
Original Assignee
Centre Europeen de Recherches Mauvernay CERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Europeen de Recherches Mauvernay CERM filed Critical Centre Europeen de Recherches Mauvernay CERM
Publication of ES8602723A1 publication Critical patent/ES8602723A1/es
Publication of ES536264A0 publication Critical patent/ES536264A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVAS N-BENCIL-PROPILAMINAS SUSTITUIDAS. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) DONDE HAL REPRESENTA HALOGENO Y PREFERIBLEMENTE CLORO, CON UN COMPUESTO DE FORMULA (III), PARA OBTENER NUEVAS N-BENCIL-PROPILAMINAS SUSTITUIDAS DE FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, DONDE X REPRESENTA UNO O DOS RADICALES SELECCIONADOS ENTRE HALOGENO, HIDROXILO, ALCOXI, ALQUILO, TRIFLUORMETILO O METILENDIOXI. LA REACCION SE REALIZA EN PRESENCIA DE UNA SUSTANCIA BASICA TAL COMO HIDROXIDO SODICO O UN COMPUESTO AMONICO CUATERNARIO. TIENEN APLICACIONES FARMACOLOGICAS POR POSEER PROPIEDADES CARDIOVASCULARES, ESPECIALMENTE PROPIEDADES CONTRA LA ANGINA DE PECHO Y ANTI-HIPERTENSIVAS.
ES536264A 1983-09-27 1984-09-26 Un procedimiento para la preparacion de nuevas n-bencil-propilaminas sustituidas. Granted ES536264A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8315367 1983-09-27

Publications (2)

Publication Number Publication Date
ES8602723A1 true ES8602723A1 (es) 1985-12-01
ES536264A0 ES536264A0 (es) 1985-12-01

Family

ID=9292587

Family Applications (1)

Application Number Title Priority Date Filing Date
ES536264A Granted ES536264A0 (es) 1983-09-27 1984-09-26 Un procedimiento para la preparacion de nuevas n-bencil-propilaminas sustituidas.

Country Status (15)

Country Link
US (1) US4645778A (es)
EP (1) EP0138684B1 (es)
JP (1) JPS6092279A (es)
KR (1) KR910003711B1 (es)
AT (1) ATE42100T1 (es)
AU (1) AU569326B2 (es)
CA (1) CA1235417A (es)
DE (1) DE3477664D1 (es)
DK (1) DK156396C (es)
ES (1) ES536264A0 (es)
FI (1) FI78081C (es)
GR (1) GR80481B (es)
HU (1) HU192589B (es)
PT (1) PT79273B (es)
ZA (1) ZA847508B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4727072A (en) * 1986-02-12 1988-02-23 Mcneilab, Inc. 3-alkoxy-2-aminopropylamines compositions and use as cardiovascular agents
US4758563A (en) * 1986-02-12 1988-07-19 Mcneilab, Inc. 3-alkoxy-2-aminopropyamines, cardiovascular compositions and use
DE3726632A1 (de) * 1987-08-11 1989-05-18 Boehringer Mannheim Gmbh 1,2-diamino-verbindungen, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
DE3726633A1 (de) * 1987-08-11 1989-02-23 Boehringer Mannheim Gmbh Neue 1,2-diamino-verbindungen, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
US4888335A (en) * 1988-07-25 1989-12-19 Mcneilab, Inc. 3-alkoxy-2-aminopropyl heterocyclic amines and their use as cardiovascular agents
US5185362A (en) * 1988-09-14 1993-02-09 Mcneilab, Inc. Diphenylamine cardiovascular agents, compositions and use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US30577A (en) * 1860-11-06 Truss-bridge
BE795735A (fr) * 1972-03-06 1973-06-18 Cerm Cent Europ Rech Mauvernay Nouvelles ethylenediamines substituees a activite cardiovasculaire
FR2378024A1 (fr) * 1977-01-25 1978-08-18 Cerm Cent Europ Rech Mauvernay Nouvelle propylamine substituee, obtention et application
GB2087233A (en) * 1980-09-30 1982-05-26 Akzo Nv Pharmaceutical compositions containing n-aryl ethanamines having anti-atherothrombosclerotic activity
FR2504925A1 (en) * 1981-05-04 1982-11-05 Cerm Cent Europ Rech Mauvernay N-2-amino 3-alkoxy or phenoxy-propyl urea and thiourea derivs. - are cardiovascular agents esp. used to treat arrhythmia
GB8330197D0 (en) * 1983-11-11 1983-12-21 Akzo Nv Ether of n-propanolamine derivative

Also Published As

Publication number Publication date
DK156396C (da) 1990-01-08
FI843785L (fi) 1985-03-28
DK156396B (da) 1989-08-14
FI843785A0 (fi) 1984-09-26
US4645778A (en) 1987-02-24
AU3354084A (en) 1985-04-04
PT79273A (en) 1984-10-01
ATE42100T1 (de) 1989-04-15
DK451884D0 (da) 1984-09-21
DE3477664D1 (en) 1989-05-18
ZA847508B (en) 1985-05-29
ES536264A0 (es) 1985-12-01
AU569326B2 (en) 1988-01-28
HUT36469A (en) 1985-09-30
HU192589B (en) 1987-06-29
EP0138684A2 (fr) 1985-04-24
JPS6092279A (ja) 1985-05-23
GR80481B (en) 1985-01-28
EP0138684B1 (fr) 1989-04-12
KR850002478A (ko) 1985-05-13
EP0138684A3 (en) 1985-06-19
FI78081C (fi) 1989-06-12
DK451884A (da) 1985-03-28
JPH0336836B2 (es) 1991-06-03
KR910003711B1 (ko) 1991-06-08
CA1235417A (en) 1988-04-19
FI78081B (fi) 1989-02-28
PT79273B (en) 1986-08-28

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