AU569326B2 - 2-(n-pyrrolidino)-3-isobutoxy-n-substituted phenyl-n-benzyl-propylamines - Google Patents

2-(n-pyrrolidino)-3-isobutoxy-n-substituted phenyl-n-benzyl-propylamines

Info

Publication number
AU569326B2
AU569326B2 AU33540/84A AU3354084A AU569326B2 AU 569326 B2 AU569326 B2 AU 569326B2 AU 33540/84 A AU33540/84 A AU 33540/84A AU 3354084 A AU3354084 A AU 3354084A AU 569326 B2 AU569326 B2 AU 569326B2
Authority
AU
Australia
Prior art keywords
propylamines
pyrrolidino
isobutoxy
benzyl
substituted phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU33540/84A
Other versions
AU3354084A (en
Inventor
Michel Combourieu
Andre Jean-Claude Monteil
Jacques Aime Louis Simond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Riom Laboratoires Cerm "rl-Cerm" Sa
Original Assignee
Centre Europeen de Recherches Mauvernay CERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Europeen de Recherches Mauvernay CERM filed Critical Centre Europeen de Recherches Mauvernay CERM
Publication of AU3354084A publication Critical patent/AU3354084A/en
Application granted granted Critical
Publication of AU569326B2 publication Critical patent/AU569326B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compounds of the formula: <IMAGE> in which X represents one or two radicals selected from halogen, hydroxyl, alkoxy, alkyl, trifluoromethyl or methylenedioxy radicals, and their pharmaceutically acceptable salts, which may be used in the treatment of cardiovascular disturbances such as angina pectoris, hypertension and rhythmic disorders.
AU33540/84A 1983-09-27 1984-09-26 2-(n-pyrrolidino)-3-isobutoxy-n-substituted phenyl-n-benzyl-propylamines Ceased AU569326B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8315367 1983-09-27
FR8315367 1983-09-27

Publications (2)

Publication Number Publication Date
AU3354084A AU3354084A (en) 1985-04-04
AU569326B2 true AU569326B2 (en) 1988-01-28

Family

ID=9292587

Family Applications (1)

Application Number Title Priority Date Filing Date
AU33540/84A Ceased AU569326B2 (en) 1983-09-27 1984-09-26 2-(n-pyrrolidino)-3-isobutoxy-n-substituted phenyl-n-benzyl-propylamines

Country Status (15)

Country Link
US (1) US4645778A (en)
EP (1) EP0138684B1 (en)
JP (1) JPS6092279A (en)
KR (1) KR910003711B1 (en)
AT (1) ATE42100T1 (en)
AU (1) AU569326B2 (en)
CA (1) CA1235417A (en)
DE (1) DE3477664D1 (en)
DK (1) DK156396C (en)
ES (1) ES8602723A1 (en)
FI (1) FI78081C (en)
GR (1) GR80481B (en)
HU (1) HU192589B (en)
PT (1) PT79273B (en)
ZA (1) ZA847508B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4727072A (en) * 1986-02-12 1988-02-23 Mcneilab, Inc. 3-alkoxy-2-aminopropylamines compositions and use as cardiovascular agents
US4758563A (en) * 1986-02-12 1988-07-19 Mcneilab, Inc. 3-alkoxy-2-aminopropyamines, cardiovascular compositions and use
DE3726632A1 (en) * 1987-08-11 1989-05-18 Boehringer Mannheim Gmbh 1,2-DIAMINO COMPOUNDS, METHOD FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
DE3726633A1 (en) * 1987-08-11 1989-02-23 Boehringer Mannheim Gmbh NEW 1,2-DIAMINO COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
US4888335A (en) * 1988-07-25 1989-12-19 Mcneilab, Inc. 3-alkoxy-2-aminopropyl heterocyclic amines and their use as cardiovascular agents
US5185362A (en) * 1988-09-14 1993-02-09 Mcneilab, Inc. Diphenylamine cardiovascular agents, compositions and use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1595031A (en) * 1977-01-25 1981-08-05 Cerm Cent Europ Rech Mauvernay 3-isobutoxy-2-pyrrolidino-n-phenyl-n-benzyl propylamine and its salts
AU3527484A (en) * 1983-11-11 1985-05-16 Akzo N.V. N-benzyl-n-phenyl-b-pyrrolidinyl-f-isobutoxy-propylamine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US30577A (en) * 1860-11-06 Truss-bridge
BE795735A (en) * 1972-03-06 1973-06-18 Cerm Cent Europ Rech Mauvernay NEW ETHYLENEDIAMINES SUBSTITUTES WITH CARDIOVASCULAR ACTIVITY
GB2087233A (en) * 1980-09-30 1982-05-26 Akzo Nv Pharmaceutical compositions containing n-aryl ethanamines having anti-atherothrombosclerotic activity
FR2504925A1 (en) * 1981-05-04 1982-11-05 Cerm Cent Europ Rech Mauvernay N-2-amino 3-alkoxy or phenoxy-propyl urea and thiourea derivs. - are cardiovascular agents esp. used to treat arrhythmia

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1595031A (en) * 1977-01-25 1981-08-05 Cerm Cent Europ Rech Mauvernay 3-isobutoxy-2-pyrrolidino-n-phenyl-n-benzyl propylamine and its salts
AU3527484A (en) * 1983-11-11 1985-05-16 Akzo N.V. N-benzyl-n-phenyl-b-pyrrolidinyl-f-isobutoxy-propylamine

Also Published As

Publication number Publication date
DK451884A (en) 1985-03-28
JPS6092279A (en) 1985-05-23
EP0138684B1 (en) 1989-04-12
CA1235417A (en) 1988-04-19
HU192589B (en) 1987-06-29
ZA847508B (en) 1985-05-29
EP0138684A3 (en) 1985-06-19
JPH0336836B2 (en) 1991-06-03
AU3354084A (en) 1985-04-04
DK156396C (en) 1990-01-08
KR910003711B1 (en) 1991-06-08
DK451884D0 (en) 1984-09-21
PT79273B (en) 1986-08-28
EP0138684A2 (en) 1985-04-24
DK156396B (en) 1989-08-14
FI78081C (en) 1989-06-12
DE3477664D1 (en) 1989-05-18
FI843785A0 (en) 1984-09-26
GR80481B (en) 1985-01-28
HUT36469A (en) 1985-09-30
ES536264A0 (en) 1985-12-01
US4645778A (en) 1987-02-24
ATE42100T1 (en) 1989-04-15
FI843785L (en) 1985-03-28
PT79273A (en) 1984-10-01
KR850002478A (en) 1985-05-13
FI78081B (en) 1989-02-28
ES8602723A1 (en) 1985-12-01

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