ES8602652A1 - Procedimiento para la preparacion de n-piridilindoles - Google Patents
Procedimiento para la preparacion de n-piridilindolesInfo
- Publication number
- ES8602652A1 ES8602652A1 ES532572A ES532572A ES8602652A1 ES 8602652 A1 ES8602652 A1 ES 8602652A1 ES 532572 A ES532572 A ES 532572A ES 532572 A ES532572 A ES 532572A ES 8602652 A1 ES8602652 A1 ES 8602652A1
- Authority
- ES
- Spain
- Prior art keywords
- pyridyl
- alkylene
- lower alkyl
- indole
- substd
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 pyridyl N-oxides Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000002947 alkylene group Chemical group 0.000 abstract 3
- 125000004450 alkenylene group Chemical group 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- GUXQOVBGUZZBPJ-MKMNVTDBSA-N (e)-2-methyl-5-(1-pyridin-3-ylindol-3-yl)pent-2-enoic acid Chemical compound C12=CC=CC=C2C(CC\C=C(/C)C(O)=O)=CN1C1=CC=CN=C1 GUXQOVBGUZZBPJ-MKMNVTDBSA-N 0.000 abstract 1
- VSKZGHVPGOMFAV-UHFFFAOYSA-N 1-pyridin-2-ylindole Chemical compound C1=CC2=CC=CC=C2N1C1=CC=CC=N1 VSKZGHVPGOMFAV-UHFFFAOYSA-N 0.000 abstract 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- UETRKVDAHIACJW-UHFFFAOYSA-N 5-(1-pyridin-3-ylindol-3-yl)pentanoic acid Chemical compound C12=CC=CC=C2C(CCCCC(=O)O)=CN1C1=CC=CN=C1 UETRKVDAHIACJW-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/495,370 US4536505A (en) | 1983-05-17 | 1983-05-17 | Certain N-(pyridyl) indoles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES532572A0 ES532572A0 (es) | 1985-12-01 |
| ES8602652A1 true ES8602652A1 (es) | 1985-12-01 |
Family
ID=23968377
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES532572A Expired ES8602652A1 (es) | 1983-05-17 | 1984-05-17 | Procedimiento para la preparacion de n-piridilindoles |
| ES545151A Expired ES8604195A1 (es) | 1983-05-17 | 1985-07-12 | Procedimiento para la preparacion de n-piridilindoles |
| ES545154A Expired ES8604922A1 (es) | 1983-05-17 | 1985-07-12 | Procedimiento para la preparacion de n-piridilindoles |
| ES545153A Expired ES8604197A1 (es) | 1983-05-17 | 1985-07-12 | Procedimiento para la preparacion de n-piridilindoles |
| ES545152A Expired ES8604196A1 (es) | 1983-05-17 | 1985-07-12 | Procedimiento para la preparacion de n-piridilindoles |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES545151A Expired ES8604195A1 (es) | 1983-05-17 | 1985-07-12 | Procedimiento para la preparacion de n-piridilindoles |
| ES545154A Expired ES8604922A1 (es) | 1983-05-17 | 1985-07-12 | Procedimiento para la preparacion de n-piridilindoles |
| ES545153A Expired ES8604197A1 (es) | 1983-05-17 | 1985-07-12 | Procedimiento para la preparacion de n-piridilindoles |
| ES545152A Expired ES8604196A1 (es) | 1983-05-17 | 1985-07-12 | Procedimiento para la preparacion de n-piridilindoles |
Country Status (15)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4675332A (en) * | 1984-12-10 | 1987-06-23 | Warner-Lambert Company | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents |
| US4609733A (en) * | 1984-12-27 | 1986-09-02 | Ciba-Geigy Corporation | 3-keto-substituted-N-pyridylindoles |
| US4758586A (en) * | 1985-02-01 | 1988-07-19 | Usv Pharmaceutical Corp. | Indolyl compounds and hyposensitivity use thereof |
| US4970218A (en) * | 1987-04-24 | 1990-11-13 | Hoechst-Roussel Pharmaceuticals Inc. | N-(pyridinyl)-1H-indol-1-amines |
| US4880822A (en) * | 1987-04-24 | 1989-11-14 | Hoechst-Roussel Pharmaceuticals, Inc. | N-(pyridinyl)-1H-indol-1-amines |
| US5039811A (en) * | 1987-04-24 | 1991-08-13 | Hoechst-Roussel Pharmaceuticals Inc. | Preparation of N-(pyridinyl)-1H-indol-1-amines |
| US5550118A (en) * | 1994-01-31 | 1996-08-27 | Eli Lilly And Company | Polyhydronorharman synthase inhibitors |
| US5977125A (en) * | 1994-10-31 | 1999-11-02 | Eisai Co., Ltd. | Mono-or polyenic carboxylic acid derivatives |
| GB2295151B (en) * | 1994-11-18 | 1998-12-09 | Nmc | Polymerization of substituted heterocyclic monomers |
| MXPA00008216A (es) * | 1998-02-23 | 2004-11-22 | Univ South Alabama | Acidos indol-3-propionicos, sales y esteres de los mismos utilizados como medicamentos. |
| AU2002362603A1 (en) * | 2001-09-26 | 2003-04-07 | Bayer Corporation | 3-pyridyl or 4-isoquinolinyl thiazoles as c17,20 lyase inhibitors |
| KR20080066949A (ko) * | 2005-10-11 | 2008-07-17 | 인터뮨, 인크. | 바이러스 복제 억제제 |
| KR100807718B1 (ko) * | 2006-10-17 | 2008-02-28 | 한국생명공학연구원 | 인돌 유도체를 유효성분으로 함유하는 대사성 질환 예방 및치료용 약학적 조성물 |
| CA2676906A1 (en) * | 2007-02-12 | 2008-08-21 | Intermune, Inc. | Novel inhibitors hepatitis c virus replication |
| MX2009010302A (es) * | 2007-03-29 | 2009-10-16 | Asubio Pharma Co Ltd | Derivados de indol que tienen actividad inhibidora de cpla2 y aplicaciones y metodos de produccion. |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3449348A (en) * | 1968-01-08 | 1969-06-10 | Merck & Co Inc | Alpha-halomethyl-1-pyridine or quinoline carbonyl-3-indolylacetic acids |
| AT299938B (de) * | 1971-02-03 | 1972-07-10 | Italiana Sint Spa | Verfahren zur Herstellung des neuen Natriumsalzes der (1-Nicotinoyl-2-methyl-5-methoxy-3-indolyl)-essigsäure, gegebenenfalls im Gemisch mit der freien Säure |
| FR2171937A1 (en) * | 1972-02-16 | 1973-09-28 | Clin Midy | Aminoketo indoles - analgesics and antidepressants |
| FR2171936B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1972-02-16 | 1975-04-25 | Clin Midy | |
| AT323154B (de) * | 1973-02-02 | 1975-06-25 | Hurka Wilhelm | Verfahren zur herstellung von neuen 5-methoxy-2-methylindol-3-essigsäurederivaten sowie von deren salzen |
| DE2862340D1 (en) * | 1978-02-01 | 1983-11-24 | Wellcome Found | Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations thereof |
| US4322533A (en) * | 1980-03-17 | 1982-03-30 | Lesher George Y | 1H-Indole-2,3-dione derivatives |
| US4363912A (en) * | 1980-12-15 | 1982-12-14 | Pfizer Inc. | Indole thromboxane synthetase inhibitors |
| CS229934B2 (en) * | 1981-07-07 | 1984-07-16 | Pfizer | Production method subst.indolylacryte acid derivative |
| GB2102795A (en) * | 1981-07-31 | 1983-02-09 | Pfizer Ltd | Indole derivatives |
| US4460777A (en) * | 1981-11-19 | 1984-07-17 | Ciba-Geigy Corporation | N-Substituted-2-pyridylindoles |
| US4478842A (en) * | 1981-11-19 | 1984-10-23 | Ciba-Geigy Corporation | N-Substituted-2-pyridylindoles |
| US4511573A (en) * | 1983-05-17 | 1985-04-16 | Ciba-Geigy Corporation | 3-Substituted-2-(heteroaryl) indoles |
-
1983
- 1983-05-17 US US06/495,370 patent/US4536505A/en not_active Expired - Fee Related
-
1984
- 1984-05-14 FI FI841925A patent/FI841925A7/fi not_active Application Discontinuation
- 1984-05-14 EP EP84105449A patent/EP0126401A1/de not_active Ceased
- 1984-05-15 PT PT78582A patent/PT78582A/pt unknown
- 1984-05-15 GR GR74706A patent/GR79934B/el unknown
- 1984-05-15 JP JP59095771A patent/JPS59212489A/ja active Pending
- 1984-05-15 IL IL71832A patent/IL71832A0/xx unknown
- 1984-05-16 HU HU841893A patent/HUT34182A/hu unknown
- 1984-05-16 ZA ZA843677A patent/ZA843677B/xx unknown
- 1984-05-16 NO NO841958A patent/NO841958L/no unknown
- 1984-05-16 DK DK242484A patent/DK242484A/da not_active Application Discontinuation
- 1984-05-16 AU AU28094/84A patent/AU2809484A/en not_active Abandoned
- 1984-05-16 DD DD84263081A patent/DD224588A5/de unknown
- 1984-05-16 KR KR1019840002658A patent/KR840009302A/ko not_active Withdrawn
- 1984-05-17 ES ES532572A patent/ES8602652A1/es not_active Expired
-
1985
- 1985-07-12 ES ES545151A patent/ES8604195A1/es not_active Expired
- 1985-07-12 ES ES545154A patent/ES8604922A1/es not_active Expired
- 1985-07-12 ES ES545153A patent/ES8604197A1/es not_active Expired
- 1985-07-12 ES ES545152A patent/ES8604196A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES8604196A1 (es) | 1986-01-16 |
| ZA843677B (en) | 1985-02-27 |
| ES532572A0 (es) | 1985-12-01 |
| KR840009302A (ko) | 1984-12-26 |
| ES545153A0 (es) | 1986-01-16 |
| ES8604197A1 (es) | 1986-01-16 |
| ES8604922A1 (es) | 1986-02-16 |
| PT78582A (en) | 1984-06-01 |
| AU2809484A (en) | 1984-11-22 |
| DK242484D0 (da) | 1984-05-16 |
| NO841958L (no) | 1984-11-19 |
| GR79934B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1984-10-31 |
| EP0126401A1 (de) | 1984-11-28 |
| ES8604195A1 (es) | 1986-01-16 |
| ES545152A0 (es) | 1986-01-16 |
| FI841925A7 (fi) | 1984-11-18 |
| IL71832A0 (en) | 1984-09-30 |
| DD224588A5 (de) | 1985-07-10 |
| FI841925A0 (fi) | 1984-05-14 |
| ES545151A0 (es) | 1986-01-16 |
| HUT34182A (en) | 1985-02-28 |
| JPS59212489A (ja) | 1984-12-01 |
| DK242484A (da) | 1984-11-18 |
| ES545154A0 (es) | 1986-02-16 |
| US4536505A (en) | 1985-08-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8602652A1 (es) | Procedimiento para la preparacion de n-piridilindoles | |
| PH31566A (en) | Pyridine and pyridine n-oxide derivatives for diaryl methyl piperidines or piperazines and compositions and methods of use thereof. | |
| PE97899A1 (es) | Forma de cristal � de la sal de adicion de acido metanosulfonico de n-[5-(4-(4-metilpiperazina metilbenzoilamido]-2-metilfenil]-4-(3-piridil)-2-pirimidina-amina | |
| HU9500247D0 (en) | Optically active salts of pyridinyl-methyl-sulfinyl-1h-benzimidazol derivatives | |
| LU90334I2 (fr) | Raloxifene et ses sels et dérivés pharmaceutiquement acceptables | |
| IL97800A0 (en) | Thiophene sulfonamide derivatives and pharmaceutical compositions containing the same | |
| NZ334476A (en) | substituted indol-3-yl glyoxylamides | |
| DK0502502T3 (da) | Topisk præparat indeholdende ketoprofenlysinat | |
| AU7941691A (en) | Antimigraine alkoxypyrimidine derivatives | |
| IL119207A0 (en) | Treatment of tinnitus using neuroprotective agents | |
| NO931058L (no) | Fremgangsmaate for fremstilling av formoterol og beslektede forbindelser | |
| BG37376A3 (en) | Method for preparing salts of benzothiazine dioxide | |
| FI890257A0 (fi) | Menetelmä terapeuttisesti käyttökelpoisten pyridiinijohdannaisten valmistamiseksi | |
| ES8607953A1 (es) | Un procedimiento para la preparacion de nuevos derivados de triazina | |
| PT790236E (pt) | Pro-farmacos de 5-(2-(4-(1,2-benzisotiazol-3-il)-1-piperazinil)-etil-6-cloro-1,3-di-hidro-2h-indol-2-ona | |
| PH21301A (en) | N-(1,8-naphthyridin--yl) amides and their pharmaceutical use | |
| GR3015716T3 (en) | Use of buspirone in sleep apneas. | |
| AU576269B2 (en) | Heterocyclic histamine h2-receptor antagonists | |
| EP0462837A3 (en) | Preparation of indole derivatives | |
| EG17621A (en) | Novel crystalline form of benzotiazine dioxide salt | |
| ES536968A0 (es) | Procedimiento para la preparacion de un nuevo derivado de 2-tolil-morfolina util en terapeutica | |
| SE8006794L (sv) | Vinkelstelldon av gangjernstyp | |
| NZ309498A (en) | 2-substituted benzyl-benzimidazole derivatives as inhibitors of smooth muscle cell proliferation | |
| AU7314391A (en) | Herbicidal pyridine derivatives and their salts of 3-(aminooxoacetyl)-2-(2-imidazolin-2-yl) | |
| RU1799384C (ru) | Способ получени производных цефалоспорина, включающих в заместителе в положении 3 азотсодержащий гетероцикл, или их фармацевтически совместимых солей с щелочными металлами |