ES8506591A1 - Un procedimiento para la preparacion de nuevas 1,2,3,4--tetrahidro-2-naftilaminas. - Google Patents
Un procedimiento para la preparacion de nuevas 1,2,3,4--tetrahidro-2-naftilaminas.Info
- Publication number
- ES8506591A1 ES8506591A1 ES529311A ES529311A ES8506591A1 ES 8506591 A1 ES8506591 A1 ES 8506591A1 ES 529311 A ES529311 A ES 529311A ES 529311 A ES529311 A ES 529311A ES 8506591 A1 ES8506591 A1 ES 8506591A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- group
- alkyl
- alkyl group
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE 1,2,3,4-TETRAHIDRO-2-NAFTILAMINAS, DE FORMULA GENERAL (I), EN LA QUE R3 Y EL GRUPO NR1R2 ESTAN EN UNA POSICION CIS, UNO CON RESPECTO AL OTRO, Y EN LA QUE Y ESTA POSICION 5 O 7, Y ES OH, Y SUS BASES Y SALES DE ADICION DE ACIDO, FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN CONVERTIR UN COMPUESTO DE FORMULA GENERAL (II) EN UN COMPUESTO DE FORMULA GENERAL (I), MEDIANTE LA ALCOHILACION DEL ATOMO DE NITROGENO CON UN AGENTE ALCOHILANTE. DE LA MEZCLA ISOMERICA OBTENIDA SE PUEDE SEPARAR UN ISOMERO PURO.DE APLICACION EN TERAPEUTICA, ESPECIALMENTE DEL SISTEMA NERVIOSO CENTRAL.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8102908 | 1981-05-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8506591A1 true ES8506591A1 (es) | 1985-08-01 |
ES529311A0 ES529311A0 (es) | 1985-08-01 |
Family
ID=20343779
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES511986A Expired ES8306708A1 (es) | 1981-05-08 | 1982-05-07 | "un procedimiento para la preparacion de nuevas 1,2,3,4 tetrahidro 2 naftilaminas". |
ES519615A Granted ES519615A0 (es) | 1981-05-08 | 1983-02-08 | Un procedimiento para la preparacion de nuevas 1,2,3,4-tetrahidro-2-naftilaminas. |
ES529311A Granted ES529311A0 (es) | 1981-05-08 | 1984-01-31 | Un procedimiento para la preparacion de nuevas 1,2,3,4--tetrahidro-2-naftilaminas. |
ES535882A Expired ES8602603A1 (es) | 1981-05-08 | 1984-09-13 | Un procedimiento para la preparacion de nuevas 1,2,3,4-tetrahidro-2-naftilaminas |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES511986A Expired ES8306708A1 (es) | 1981-05-08 | 1982-05-07 | "un procedimiento para la preparacion de nuevas 1,2,3,4 tetrahidro 2 naftilaminas". |
ES519615A Granted ES519615A0 (es) | 1981-05-08 | 1983-02-08 | Un procedimiento para la preparacion de nuevas 1,2,3,4-tetrahidro-2-naftilaminas. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES535882A Expired ES8602603A1 (es) | 1981-05-08 | 1984-09-13 | Un procedimiento para la preparacion de nuevas 1,2,3,4-tetrahidro-2-naftilaminas |
Country Status (16)
Country | Link |
---|---|
US (1) | US4876284A (es) |
EP (1) | EP0064964B1 (es) |
JP (1) | JPS57192344A (es) |
AT (1) | ATE8874T1 (es) |
AU (2) | AU554206B2 (es) |
CA (1) | CA1236113A (es) |
DE (1) | DE3260529D1 (es) |
DK (1) | DK164937C (es) |
ES (4) | ES8306708A1 (es) |
FI (1) | FI78067C (es) |
GR (1) | GR77121B (es) |
IE (1) | IE53143B1 (es) |
IL (1) | IL65501A (es) |
NO (1) | NO152902C (es) |
NZ (1) | NZ200526A (es) |
PH (2) | PH18065A (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL65501A (en) * | 1981-05-08 | 1986-04-29 | Astra Laekemedel Ab | 1-alkyl-2-aminotetralin derivatives,process for their preparation and pharmaceutical compositions containing them |
US4657925A (en) * | 1984-08-13 | 1987-04-14 | Nelson Research & Development Co. | Method and compositions for reducing the intraocular pressure of mammals |
US4743618A (en) * | 1983-01-03 | 1988-05-10 | Nelson Research & Development Co. | Substituted 2-aminotetralins |
US4722933A (en) * | 1985-12-20 | 1988-02-02 | Nelson Research & Development Co. | Substituted 2-aminotetralins |
GB2157950B (en) * | 1984-05-04 | 1988-11-02 | Nelson Res & Dev | Selective d-2 dopamine receptor agonist |
AU573828B2 (en) * | 1984-05-17 | 1988-06-23 | E.R. Squibb & Sons, Inc. | Tetrahydronaphthalenols |
EP0168505B1 (en) * | 1984-05-22 | 1989-08-09 | Whitby Research Incorporated | Substituted 2-aminotetralins and processes for synthesis |
DE3718317A1 (de) * | 1986-12-10 | 1988-06-16 | Bayer Ag | Substituierte basische 2-aminotetraline |
JPH03505735A (ja) * | 1988-07-29 | 1991-12-12 | シェリング・コーポレーション | ヘキサヒドロ―ベンゾ[d]―ナフト[2,1―b]アゼピンのための中間体の対掌体特異的合成のための方法 |
US5091526A (en) * | 1988-07-29 | 1992-02-25 | Schering Corporation | Process for the enantiospecific synthesis of intermediates for hexahydro-benzo[d]-naphtho[2,1-b]azepines |
CA1335106C (en) * | 1989-02-27 | 1995-04-04 | John Mehnert Schaus | Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes |
SE8901889D0 (sv) * | 1989-05-26 | 1989-05-26 | Astra Ab | Novel 8-substituted-2-aminotetralines |
HUT61719A (en) * | 1989-05-31 | 1993-03-01 | Upjohn Co | Process for producing 2-aminotetraline derivatives and pharmaceutical compositions comprising such compounds |
IT1232160B (it) * | 1989-07-31 | 1992-01-25 | Sigma Tau Ind Farmaceuti | 2-(n-acil)ammino-6,7-dimetossi tetraline, procedimento per la loro preparazione e composizioni farmaceutiche ad attivita' antiipertensiva che le contengono |
WO1991009594A1 (en) * | 1989-12-28 | 1991-07-11 | Virginia Commonwealth University | Sigma receptor ligands and the use thereof |
DE69124868T2 (de) * | 1990-08-15 | 1997-07-10 | Lilly Co Eli | Ring-substituierte 2-Amino-1,2,3,4-tetra-hydronaphthaline, 3-Aminochromane und 3-Aminothiochromane |
AU1915192A (en) * | 1991-04-26 | 1992-12-21 | Upjohn Company, The | Method of treating/preventing substance abuse using 1-alkyl-5(substituted oxy)-2-aminotetralins |
PT100639A (pt) * | 1991-06-27 | 1993-09-30 | Univ Virginia Commonwealth | Metodo para o tratamento terapeutico com compostos que sao ligandos ao receptor sigma e compostos ai utilizados, nomeadamente derivados fenilalquil-amina, aminotetralina,piperazina e piperidina |
IT1251877B (it) * | 1991-09-26 | 1995-05-26 | Zambon Spa | Processo per la preparazione di 2-ammino-5,6 dimetossi-tetralina |
EP0697894A4 (en) * | 1993-03-31 | 1996-05-01 | Univ Pennsylvania | DOPAMINE D-3 AND SEROTONIN (5-HT 1A) RECEPTOR LIGANDS AND IMAGING AGENTS |
CA2166100A1 (en) * | 1993-06-23 | 1995-01-05 | Richard A. Glennon | Sigma receptor ligands and the use thereof |
GB9315566D0 (en) * | 1993-07-28 | 1993-09-08 | Smithkline Beecham Plc | Medicaments |
WO1996030333A1 (en) * | 1995-03-27 | 1996-10-03 | Smithkline Beecham Plc | Bicyclic amine derivatives and their use as anti-psychotic agents |
US5646188A (en) * | 1995-07-05 | 1997-07-08 | Teva Pharmaceutical Industries, Ltd. | Polyamine derivatives of 1-aminoindan |
NZ510988A (en) | 1998-10-07 | 2005-01-28 | Ortho Mcneil Pharm Inc | N-aralkylaminotetralins useful as ligands for the neuropeptide Y5 receptor |
EP1506166B1 (en) | 2002-05-17 | 2011-11-16 | Janssen Pharmaceutica NV | Aminotetralin-derived urea modulators of vanilloid vr1 receptor |
EP2098511A1 (en) | 2008-03-07 | 2009-09-09 | Solvias AG | Process for preparing compounds containing a hydronaphtalene structure with an unsymmetrically substituted benzene ring |
DE102010020553A1 (de) | 2010-05-14 | 2011-11-17 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 8-Alkoxy-2-aminotetralin-Derivate und ihre Verwendung |
SG11201408421TA (en) | 2012-07-20 | 2015-02-27 | Bayer Pharma AG | Novel 5-aminotetrahydroquinoline-2-carboxylic acids and use thereof |
CN104703964B (zh) | 2012-07-20 | 2017-04-12 | 拜耳制药股份公司 | 取代氨基茚满‑和氨基萘满甲酸及其用途 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1017359A (en) * | 1972-07-03 | 1977-09-13 | Frederic P. Hauck | Substituted cyclic polymethylene phenols |
JPS5124508B2 (es) * | 1972-08-14 | 1976-07-24 | ||
DE2752659A1 (de) * | 1976-12-07 | 1978-06-08 | Sandoz Ag | Neue tetralinderivate, ihre herstellung und verwendung |
DE3062971D1 (en) * | 1979-09-14 | 1983-06-09 | Sandoz Ag | Derivatives of tetraline, their preparation and medicaments containing these compounds |
AU7179781A (en) * | 1980-05-29 | 1981-12-21 | Astra Lakemedel Aktiebolag | Therapeutically useful tetralin derivatives |
IL65501A (en) * | 1981-05-08 | 1986-04-29 | Astra Laekemedel Ab | 1-alkyl-2-aminotetralin derivatives,process for their preparation and pharmaceutical compositions containing them |
FR2512814A1 (fr) * | 1981-09-16 | 1983-03-18 | Synthelabo | Derives d'amino-2 tetrahydro-1,2,3,4 naphtalene, leur preparation et leur application en therapeutique |
-
1982
- 1982-04-15 IL IL65501A patent/IL65501A/xx not_active IP Right Cessation
- 1982-04-28 CA CA000401881A patent/CA1236113A/en not_active Expired
- 1982-05-05 AU AU83409/82A patent/AU554206B2/en not_active Ceased
- 1982-05-05 PH PH27236A patent/PH18065A/en unknown
- 1982-05-05 NZ NZ200526A patent/NZ200526A/en unknown
- 1982-05-06 DK DK202882A patent/DK164937C/da not_active IP Right Cessation
- 1982-05-06 EP EP82850102A patent/EP0064964B1/en not_active Expired
- 1982-05-06 NO NO821494A patent/NO152902C/no unknown
- 1982-05-06 FI FI821598A patent/FI78067C/fi not_active IP Right Cessation
- 1982-05-06 DE DE8282850102T patent/DE3260529D1/de not_active Expired
- 1982-05-06 AT AT82850102T patent/ATE8874T1/de active
- 1982-05-06 IE IE1076/82A patent/IE53143B1/en not_active IP Right Cessation
- 1982-05-07 JP JP57075554A patent/JPS57192344A/ja active Granted
- 1982-05-07 GR GR68101A patent/GR77121B/el unknown
- 1982-05-07 ES ES511986A patent/ES8306708A1/es not_active Expired
-
1983
- 1983-02-08 ES ES519615A patent/ES519615A0/es active Granted
-
1984
- 1984-01-31 ES ES529311A patent/ES529311A0/es active Granted
- 1984-03-19 AU AU25879/84A patent/AU572497B2/en not_active Ceased
- 1984-06-08 PH PH30792A patent/PH19585A/en unknown
- 1984-09-13 ES ES535882A patent/ES8602603A1/es not_active Expired
-
1988
- 1988-01-11 US US07/143,260 patent/US4876284A/en not_active Expired - Fee Related
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19990201 |