ES8505252A1 - Procedimiento para preparar derivados del cornezuelo del centeno - Google Patents
Procedimiento para preparar derivados del cornezuelo del centenoInfo
- Publication number
- ES8505252A1 ES8505252A1 ES529759A ES529759A ES8505252A1 ES 8505252 A1 ES8505252 A1 ES 8505252A1 ES 529759 A ES529759 A ES 529759A ES 529759 A ES529759 A ES 529759A ES 8505252 A1 ES8505252 A1 ES 8505252A1
- Authority
- ES
- Spain
- Prior art keywords
- agents
- ergolin
- sulfamide
- diethyl
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ARTRTLXKTHJPRW-UHFFFAOYSA-N 9-(diethylsulfamoylamino)-4-ethyl-7-methyl-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline Chemical compound C1=CC(C2CC(CN(C)C2C2)NS(=O)(=O)N(CC)CC)=C3C2=CN(CC)C3=C1 ARTRTLXKTHJPRW-UHFFFAOYSA-N 0.000 title abstract 2
- 102000003946 Prolactin Human genes 0.000 title abstract 2
- 108010057464 Prolactin Proteins 0.000 title abstract 2
- 239000000935 antidepressant agent Substances 0.000 title abstract 2
- 239000000939 antiparkinson agent Substances 0.000 title abstract 2
- 229940125688 antiparkinson agent Drugs 0.000 title abstract 2
- 229940097325 prolactin Drugs 0.000 title abstract 2
- 230000028327 secretion Effects 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
- C07D457/12—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DEL CORNEZUELO DEL CENTENO Y DE SUS SALES DE ADICION DE ACIDO, DE FORMULA (I), EN LA QUE R ES ETILO O PROPILO.CONSISTE EN LA REACCION DE ALQUILACION DE UN COMPUESTO DE FORMULA (II), MEDIANTE TRATAMIENTO CON UN COMPUESTO DE FORMULA R-X, EN LA QUE X PUEDE SER VARIOS RADICALES Y R ES ETILO O PROPILO, EN AMONIACO LIQUIDO, A UNA TEMPERATURA ENTRE C40JC Y LA DE EBULLICION.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTI-PARKINSON.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH862/83A CH652719A5 (en) | 1983-02-16 | 1983-02-16 | Ergoline derivatives, their preparation and use |
| CH86383A CH652720A5 (en) | 1983-02-16 | 1983-02-16 | Ergoline derivatives, their preparation and use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8505252A1 true ES8505252A1 (es) | 1985-05-16 |
| ES529759A0 ES529759A0 (es) | 1985-05-16 |
Family
ID=25685928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES529759A Granted ES529759A0 (es) | 1983-02-16 | 1984-02-15 | Procedimiento para preparar derivados del cornezuelo del centeno |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4791116A (es) |
| AT (1) | AT386410B (es) |
| AU (1) | AU572822B2 (es) |
| CA (1) | CA1208630A (es) |
| DE (1) | DE3404400A1 (es) |
| DK (1) | DK67284A (es) |
| ES (1) | ES529759A0 (es) |
| FI (1) | FI80034C (es) |
| FR (1) | FR2540874B1 (es) |
| GB (1) | GB2135307B (es) |
| GR (1) | GR81770B (es) |
| HU (1) | HU196399B (es) |
| IE (1) | IE56871B1 (es) |
| IL (1) | IL70954A (es) |
| IT (1) | IT1199062B (es) |
| MY (1) | MY8700270A (es) |
| NL (1) | NL8400333A (es) |
| NZ (1) | NZ207145A (es) |
| PH (1) | PH24707A (es) |
| PL (1) | PL246230A1 (es) |
| PT (1) | PT78101B (es) |
| SE (1) | SE459970B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3915950A1 (de) * | 1989-05-12 | 1990-11-15 | Schering Ag | 8(alpha)-acylamino-ergoline, ihre herstellung und verwendung als arzneimittel |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1573621A (en) * | 1976-01-02 | 1980-08-28 | Sandoz Ltd | Acylated 6-methyl-8a-amino-ergoline i compounds |
| US4348392A (en) * | 1974-07-19 | 1982-09-07 | Sandoz Ltd. | 8α-Substituted ergoline-I derivatives |
| DE2656344A1 (de) * | 1975-12-23 | 1977-07-07 | Sandoz Ag | Ergolinderivate, ihre verwendung und herstellung |
| CH622518A5 (en) * | 1976-12-14 | 1981-04-15 | Sandoz Ag | Process for the preparation of novel ergoline compounds |
| DE3127845A1 (de) * | 1980-07-25 | 1982-04-22 | Sandoz-Patent-GmbH, 7850 Lörrach | Ergolinderivate, verfahren zu deren herstellung, diese enthaltende pharmazeutische zusammensetzungen und ihre anwendung bei der therapeutischen behandlung |
| DE3151912A1 (de) * | 1981-12-23 | 1983-06-30 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue ergolin-aminoderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel |
| PH21123A (en) * | 1983-04-28 | 1987-07-27 | Erba Farmitalia | Ergoline derivatives |
-
1984
- 1984-02-03 HU HU84463A patent/HU196399B/hu not_active IP Right Cessation
- 1984-02-03 NL NL8400333A patent/NL8400333A/nl not_active Application Discontinuation
- 1984-02-08 DE DE19843404400 patent/DE3404400A1/de not_active Withdrawn
- 1984-02-09 FR FR8402128A patent/FR2540874B1/fr not_active Expired
- 1984-02-13 GB GB08403723A patent/GB2135307B/en not_active Expired
- 1984-02-13 PL PL24623084A patent/PL246230A1/xx unknown
- 1984-02-14 CA CA000447409A patent/CA1208630A/en not_active Expired
- 1984-02-14 GR GR73799A patent/GR81770B/el unknown
- 1984-02-14 SE SE8400782A patent/SE459970B/sv not_active IP Right Cessation
- 1984-02-14 PH PH30239A patent/PH24707A/en unknown
- 1984-02-14 IT IT47681/84A patent/IT1199062B/it active
- 1984-02-14 IL IL70954A patent/IL70954A/xx unknown
- 1984-02-14 PT PT78101A patent/PT78101B/pt not_active IP Right Cessation
- 1984-02-14 NZ NZ207145A patent/NZ207145A/en unknown
- 1984-02-14 FI FI840587A patent/FI80034C/fi not_active IP Right Cessation
- 1984-02-14 DK DK67284A patent/DK67284A/da not_active Application Discontinuation
- 1984-02-15 IE IE353/84A patent/IE56871B1/xx unknown
- 1984-02-15 ES ES529759A patent/ES529759A0/es active Granted
- 1984-02-15 AU AU24625/84A patent/AU572822B2/en not_active Ceased
- 1984-02-15 AT AT0047984A patent/AT386410B/de not_active IP Right Cessation
-
1986
- 1986-12-01 US US06/936,204 patent/US4791116A/en not_active Expired - Fee Related
-
1987
- 1987-12-30 MY MY270/87A patent/MY8700270A/xx unknown
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