ES8504840A1 - Un procedimiento para la preparacion de nuevos antibioticos,en especial derivados de omt modificados en c-23. - Google Patents

Un procedimiento para la preparacion de nuevos antibioticos,en especial derivados de omt modificados en c-23.

Info

Publication number
ES8504840A1
ES8504840A1 ES524196A ES524196A ES8504840A1 ES 8504840 A1 ES8504840 A1 ES 8504840A1 ES 524196 A ES524196 A ES 524196A ES 524196 A ES524196 A ES 524196A ES 8504840 A1 ES8504840 A1 ES 8504840A1
Authority
ES
Spain
Prior art keywords
optionally substituted
alkanoyl
hydrogen
phenylpropionyl
phenylacetyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES524196A
Other languages
English (en)
Other versions
ES524196A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES8504840A1 publication Critical patent/ES8504840A1/es
Publication of ES524196A0 publication Critical patent/ES524196A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Hydrogenated Pyridines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS ANTIBIOTICOS, EN ESPECIAL DERIVADOS DE OMT MODIFICADOS EN C-23, DE FORMULA GENERAL (I), Y SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN SOMETER UN COMPUESTO DE FORMULA (I) EN LA QUE R ES AZIDO A UNA REACCION DE REDUCCION CON TRIFENILFOSFINA, A UNA TEMPERATURA COMPRENDIDA ENTRE CERP Y CIEN GRADOS, PARA FORMAR UN COMPUESTO DE FORMULA (I) EN LA QUE R ES -NH2 Y, OPCIONALMENTE, EN ACILAR EL AMINO DERIVADO PARA FORMAR UN COMPUESTO DE FORMULA (I) EN LA QUE R ES -NHR.DE APLICACION COMO AGENTES PROMOTORES DEL CRECIMIENTO DE LOS ANIMALES.
ES524196A 1982-07-19 1983-07-18 Un procedimiento para la preparacion de nuevos antibioticos,en especial derivados de omt modificados en c-23. Granted ES524196A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/399,657 US4459290A (en) 1982-07-19 1982-07-19 C-23-Modified derivatives of OMT, pharmaceutical compositions and method of use

Publications (2)

Publication Number Publication Date
ES8504840A1 true ES8504840A1 (es) 1985-05-01
ES524196A0 ES524196A0 (es) 1985-05-01

Family

ID=23580431

Family Applications (1)

Application Number Title Priority Date Filing Date
ES524196A Granted ES524196A0 (es) 1982-07-19 1983-07-18 Un procedimiento para la preparacion de nuevos antibioticos,en especial derivados de omt modificados en c-23.

Country Status (19)

Country Link
US (1) US4459290A (es)
EP (1) EP0099747B1 (es)
JP (1) JPS5931795A (es)
KR (1) KR850000967B1 (es)
AT (1) ATE25689T1 (es)
AU (1) AU1693483A (es)
CA (1) CA1202965A (es)
DD (1) DD210060A5 (es)
DE (1) DE3369997D1 (es)
DK (1) DK330383D0 (es)
ES (1) ES524196A0 (es)
FI (1) FI832603A (es)
GB (1) GB2123828B (es)
GR (1) GR78388B (es)
NZ (1) NZ204939A (es)
PH (1) PH19929A (es)
PL (1) PL243090A1 (es)
PT (1) PT77039A (es)
ZA (1) ZA835217B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4515941A (en) * 1982-04-07 1985-05-07 Toyo Jozo Kabushiki Kaisha 23-Demycinosyldesmycosin derivatives
JPS59141596A (ja) * 1983-02-03 1984-08-14 Toyo Jozo Co Ltd ３−ｏ−アシル−４″−デオキシデスマイコシン誘導体およびその製法
US4629786A (en) * 1983-02-28 1986-12-16 Eli Lilly And Company C-20- and C-23 modified macrolide derivatives
DE3310533A1 (de) * 1983-03-23 1984-09-27 Bayer Ag, 5090 Leverkusen Organisch-chemische verbindungen und verfahren zu ihrer herstellung
JPS6098540A (ja) * 1983-11-04 1985-06-01 Mitsubishi Electric Corp 磁気記録再生装置
JPS60115038A (ja) * 1983-11-26 1985-06-21 Mitsubishi Electric Corp 磁気録画再生装置
US4604380A (en) * 1985-01-18 1986-08-05 Eli Lilly And Company C-23-substituted mycaminosyltylonolide compounds, pharmaceutical compositions and methods of use
US4581345A (en) * 1985-04-08 1986-04-08 Merck & Co., Inc. Avermectin 8,9-cyclopropyl compounds, pharmaceutical composition and therapeutic methods of use
US6753415B2 (en) 2002-04-19 2004-06-22 Enanta Pharmaceuticals, Inc. 23-O-substituted 5-O-mycaminosyltylonide derivatives
AU2006206952B2 (en) 2005-01-24 2011-08-18 Microbial Chemistry Research Foundation Anti-penicillin resistant pneumococci agent and novel 16-membered ring macrolide derivative

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE667952A (es) * 1964-08-05
US4252898A (en) * 1979-05-23 1981-02-24 Eli Lilly And Company Antibiotics A6888C and A6888X
JPS56122397A (en) * 1980-02-29 1981-09-25 Satoshi Omura Marcolides
US4321362A (en) * 1980-06-12 1982-03-23 Eli Lilly And Company De(mycinosyloxy)tylosin and process for its production
US4438109A (en) * 1980-07-25 1984-03-20 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Tylosin derivatives
US4341771A (en) * 1981-04-20 1982-07-27 Eli Lilly And Company Method of controlling Pasteurella infections
US4341770A (en) * 1981-04-20 1982-07-27 Eli Lilly And Company Method of controlling ureaplasma infections
AU551142B2 (en) * 1981-07-09 1986-04-17 Zaidan Hojin Biseibutsu Kagaku Kenkyukai Tylosin derivatives

Also Published As

Publication number Publication date
GB2123828A (en) 1984-02-08
PT77039A (en) 1983-08-01
GB8319307D0 (en) 1983-08-17
PL243090A1 (en) 1984-07-16
KR850000967B1 (ko) 1985-07-02
DK330383D0 (da) 1983-07-18
US4459290A (en) 1984-07-10
GB2123828B (en) 1985-11-13
DE3369997D1 (en) 1987-04-09
PH19929A (en) 1986-08-14
NZ204939A (en) 1986-08-08
FI832603A (fi) 1984-01-20
KR840005463A (ko) 1984-11-12
GR78388B (es) 1984-09-26
EP0099747B1 (en) 1987-03-04
ES524196A0 (es) 1985-05-01
JPS5931795A (ja) 1984-02-20
AU1693483A (en) 1984-01-26
ATE25689T1 (de) 1987-03-15
CA1202965A (en) 1986-04-08
DD210060A5 (de) 1984-05-30
EP0099747A1 (en) 1984-02-01
ZA835217B (en) 1984-03-28
FI832603A0 (fi) 1983-07-18

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