ATE25689T1 - 5-0-mycaminosyl-tylonolide derivate, modifiziert an position c-23. - Google Patents
5-0-mycaminosyl-tylonolide derivate, modifiziert an position c-23.Info
- Publication number
- ATE25689T1 ATE25689T1 AT83304154T AT83304154T ATE25689T1 AT E25689 T1 ATE25689 T1 AT E25689T1 AT 83304154 T AT83304154 T AT 83304154T AT 83304154 T AT83304154 T AT 83304154T AT E25689 T1 ATE25689 T1 AT E25689T1
- Authority
- AT
- Austria
- Prior art keywords
- optionally substituted
- alkanoyl
- hydrogen
- phenylpropionyl
- phenylacetyl
- Prior art date
Links
- -1 -S-R4 Chemical group 0.000 abstract 10
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 3
- WGUJDBLMJBJUQU-VKRLOHBMSA-N 5-O-mycaminosyltylonolide Chemical class O=CC[C@H]1C[C@@H](C)C(=O)\C=C\C(\C)=C\[C@H](CO)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O[C@H]1[C@H](O)[C@@H](N(C)C)[C@H](O)[C@@H](C)O1 WGUJDBLMJBJUQU-VKRLOHBMSA-N 0.000 abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 2
- 229940088710 antibiotic agent Drugs 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000001786 isothiazolyl group Chemical group 0.000 abstract 1
- 125000000842 isoxazolyl group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001715 oxadiazolyl group Chemical group 0.000 abstract 1
- 125000002971 oxazolyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000405 phenylalanyl group Chemical group 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003831 tetrazolyl group Chemical group 0.000 abstract 1
- 125000001113 thiadiazolyl group Chemical group 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000004306 triazinyl group Chemical group 0.000 abstract 1
- 125000001425 triazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Hydrogenated Pyridines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/399,657 US4459290A (en) | 1982-07-19 | 1982-07-19 | C-23-Modified derivatives of OMT, pharmaceutical compositions and method of use |
| EP83304154A EP0099747B1 (de) | 1982-07-19 | 1983-07-18 | 5-0-Mycaminosyl-tylonolide Derivate, modifiziert an Position C-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE25689T1 true ATE25689T1 (de) | 1987-03-15 |
Family
ID=23580431
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT83304154T ATE25689T1 (de) | 1982-07-19 | 1983-07-18 | 5-0-mycaminosyl-tylonolide derivate, modifiziert an position c-23. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4459290A (de) |
| EP (1) | EP0099747B1 (de) |
| JP (1) | JPS5931795A (de) |
| KR (1) | KR850000967B1 (de) |
| AT (1) | ATE25689T1 (de) |
| AU (1) | AU1693483A (de) |
| CA (1) | CA1202965A (de) |
| DD (1) | DD210060A5 (de) |
| DE (1) | DE3369997D1 (de) |
| DK (1) | DK330383D0 (de) |
| ES (1) | ES8504840A1 (de) |
| FI (1) | FI832603A7 (de) |
| GB (1) | GB2123828B (de) |
| GR (1) | GR78388B (de) |
| NZ (1) | NZ204939A (de) |
| PH (1) | PH19929A (de) |
| PL (1) | PL243090A1 (de) |
| PT (1) | PT77039A (de) |
| ZA (1) | ZA835217B (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4515941A (en) * | 1982-04-07 | 1985-05-07 | Toyo Jozo Kabushiki Kaisha | 23-Demycinosyldesmycosin derivatives |
| JPS59141596A (ja) * | 1983-02-03 | 1984-08-14 | Toyo Jozo Co Ltd | ３−ｏ−アシル−４″−デオキシデスマイコシン誘導体およびその製法 |
| US4629786A (en) * | 1983-02-28 | 1986-12-16 | Eli Lilly And Company | C-20- and C-23 modified macrolide derivatives |
| DE3310533A1 (de) * | 1983-03-23 | 1984-09-27 | Bayer Ag, 5090 Leverkusen | Organisch-chemische verbindungen und verfahren zu ihrer herstellung |
| JPS6098540A (ja) * | 1983-11-04 | 1985-06-01 | Mitsubishi Electric Corp | 磁気記録再生装置 |
| JPS60115038A (ja) * | 1983-11-26 | 1985-06-21 | Mitsubishi Electric Corp | 磁気録画再生装置 |
| US4604380A (en) * | 1985-01-18 | 1986-08-05 | Eli Lilly And Company | C-23-substituted mycaminosyltylonolide compounds, pharmaceutical compositions and methods of use |
| US4581345A (en) * | 1985-04-08 | 1986-04-08 | Merck & Co., Inc. | Avermectin 8,9-cyclopropyl compounds, pharmaceutical composition and therapeutic methods of use |
| US6753415B2 (en) * | 2002-04-19 | 2004-06-22 | Enanta Pharmaceuticals, Inc. | 23-O-substituted 5-O-mycaminosyltylonide derivatives |
| CA2595211C (en) | 2005-01-24 | 2012-08-21 | Microbial Chemistry Research Foundation | Anti-penicillin resistant pneumococci agent and novel 16-membered macrolide derivative |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE667952A (de) * | 1964-08-05 | |||
| US4252898A (en) * | 1979-05-23 | 1981-02-24 | Eli Lilly And Company | Antibiotics A6888C and A6888X |
| JPS56122397A (en) * | 1980-02-29 | 1981-09-25 | Satoshi Omura | Marcolides |
| US4321362A (en) * | 1980-06-12 | 1982-03-23 | Eli Lilly And Company | De(mycinosyloxy)tylosin and process for its production |
| US4438109A (en) * | 1980-07-25 | 1984-03-20 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Tylosin derivatives |
| US4341770A (en) * | 1981-04-20 | 1982-07-27 | Eli Lilly And Company | Method of controlling ureaplasma infections |
| US4341771A (en) * | 1981-04-20 | 1982-07-27 | Eli Lilly And Company | Method of controlling Pasteurella infections |
| AU551142B2 (en) * | 1981-07-09 | 1986-04-17 | Zaidan Hojin Biseibutsu Kagaku Kenkyukai | Tylosin derivatives |
-
1982
- 1982-07-19 US US06/399,657 patent/US4459290A/en not_active Expired - Fee Related
-
1983
- 1983-07-18 DE DE8383304154T patent/DE3369997D1/de not_active Expired
- 1983-07-18 EP EP83304154A patent/EP0099747B1/de not_active Expired
- 1983-07-18 PH PH29240A patent/PH19929A/en unknown
- 1983-07-18 AT AT83304154T patent/ATE25689T1/de not_active IP Right Cessation
- 1983-07-18 ES ES524196A patent/ES8504840A1/es not_active Expired
- 1983-07-18 AU AU16934/83A patent/AU1693483A/en not_active Abandoned
- 1983-07-18 KR KR1019830003275A patent/KR850000967B1/ko not_active Expired
- 1983-07-18 PT PT77039A patent/PT77039A/pt unknown
- 1983-07-18 FI FI832603A patent/FI832603A7/fi not_active Application Discontinuation
- 1983-07-18 GR GR71961A patent/GR78388B/el unknown
- 1983-07-18 CA CA000432588A patent/CA1202965A/en not_active Expired
- 1983-07-18 JP JP58131792A patent/JPS5931795A/ja active Pending
- 1983-07-18 ZA ZA835217A patent/ZA835217B/xx unknown
- 1983-07-18 NZ NZ204939A patent/NZ204939A/en unknown
- 1983-07-18 GB GB08319307A patent/GB2123828B/en not_active Expired
- 1983-07-18 DK DK3303/83A patent/DK330383D0/da not_active Application Discontinuation
- 1983-07-19 DD DD83253192A patent/DD210060A5/de unknown
- 1983-07-19 PL PL24309083A patent/PL243090A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU1693483A (en) | 1984-01-26 |
| DD210060A5 (de) | 1984-05-30 |
| GR78388B (de) | 1984-09-26 |
| EP0099747B1 (de) | 1987-03-04 |
| DE3369997D1 (en) | 1987-04-09 |
| KR850000967B1 (ko) | 1985-07-02 |
| CA1202965A (en) | 1986-04-08 |
| JPS5931795A (ja) | 1984-02-20 |
| ZA835217B (en) | 1984-03-28 |
| PH19929A (en) | 1986-08-14 |
| GB2123828A (en) | 1984-02-08 |
| NZ204939A (en) | 1986-08-08 |
| PT77039A (en) | 1983-08-01 |
| GB8319307D0 (en) | 1983-08-17 |
| ES524196A0 (es) | 1985-05-01 |
| FI832603A0 (fi) | 1983-07-18 |
| DK330383D0 (da) | 1983-07-18 |
| PL243090A1 (en) | 1984-07-16 |
| US4459290A (en) | 1984-07-10 |
| GB2123828B (en) | 1985-11-13 |
| FI832603A7 (fi) | 1984-01-20 |
| ES8504840A1 (es) | 1985-05-01 |
| KR840005463A (ko) | 1984-11-12 |
| EP0099747A1 (de) | 1984-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |