ES8501388A1 - Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas - Google Patents

Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas

Info

Publication number
ES8501388A1
ES8501388A1 ES526727A ES526727A ES8501388A1 ES 8501388 A1 ES8501388 A1 ES 8501388A1 ES 526727 A ES526727 A ES 526727A ES 526727 A ES526727 A ES 526727A ES 8501388 A1 ES8501388 A1 ES 8501388A1
Authority
ES
Spain
Prior art keywords
methyl
oct
aza
pyridinyl
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES526727A
Other languages
English (en)
Other versions
ES526727A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES526727A0 publication Critical patent/ES526727A0/es
Publication of ES8501388A1 publication Critical patent/ES8501388A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/38—[b, e]- or [b, f]-condensed with six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DIBENZODIAZEPINONAS SUSTITUIDAS Y DE SUS SALES DE ADICION DE ACIDOS DE FORMULA (I), EN LA QUE R1 ES HIDROGENO O CLORO; Y R PUEDE SER VARIOS RADICALES.CONSISTE EN LA REACCION DE UNA 5-DIALCOHILFOSFONO-ACETILDIBENZODIAZEPINONA, DE FORMULA (II), CON UNA PIPERIDINONA, DE FORMULA (III), O UNA TREPINONA, DE FORMULA (IV), EN LAS QUE R1 ES EL MISMO QUE EN LA FORMULA (I), R2 ES ALCOHILO C1-10 Y R3 ES HIDROGENO O METILO, EN UN DISOLVENTE, EN PRESENCIA DE UN HIDRURO O ALCOHOLATO ALCALINO, A TEMPERATURAS ENTRE 20JC Y LA DE EBULLICION DE LA MEZCLA.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS EFECTOS ANTIULCEROGENOS E INHIBIDORES DE SECRECION DE JUGOS GASTRICOS.
ES526727A 1982-02-06 1983-10-25 Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas Expired ES8501388A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823204157 DE3204157A1 (de) 1982-02-06 1982-02-06 Substituierte dibenzodiazepinone, verfahren zu ihrer herstellung und sie enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
ES526727A0 ES526727A0 (es) 1984-11-16
ES8501388A1 true ES8501388A1 (es) 1984-11-16

Family

ID=6155013

Family Applications (5)

Application Number Title Priority Date Filing Date
ES519531A Expired ES8403120A1 (es) 1982-02-06 1983-02-04 Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas
ES526727A Expired ES8501388A1 (es) 1982-02-06 1983-10-25 Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas
ES526729A Granted ES526729A0 (es) 1982-02-06 1983-10-25 Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas
ES526726A Granted ES526726A0 (es) 1982-02-06 1983-10-25 Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas
ES526728A Expired ES8501389A1 (es) 1982-02-06 1983-10-25 Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES519531A Expired ES8403120A1 (es) 1982-02-06 1983-02-04 Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES526729A Granted ES526729A0 (es) 1982-02-06 1983-10-25 Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas
ES526726A Granted ES526726A0 (es) 1982-02-06 1983-10-25 Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas
ES526728A Expired ES8501389A1 (es) 1982-02-06 1983-10-25 Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas

Country Status (25)

Country Link
US (1) US4447434A (es)
EP (1) EP0085892B1 (es)
JP (1) JPS58146581A (es)
KR (1) KR900005278B1 (es)
AT (1) ATE17002T1 (es)
AU (1) AU557463B2 (es)
CA (1) CA1189507A (es)
CS (1) CS241138B2 (es)
DD (1) DD207200A1 (es)
DE (2) DE3204157A1 (es)
DK (1) DK48983A (es)
ES (5) ES8403120A1 (es)
FI (1) FI75818C (es)
GB (1) GB2115411B (es)
GR (1) GR78060B (es)
HK (1) HK90189A (es)
HU (1) HU190708B (es)
IE (1) IE54552B1 (es)
IL (1) IL67836A (es)
NO (1) NO158623C (es)
NZ (1) NZ203192A (es)
PL (1) PL138523B1 (es)
PT (1) PT76198B (es)
SU (1) SU1301314A3 (es)
ZA (1) ZA83774B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3402060A1 (de) * 1984-01-21 1985-08-01 Dr. Karl Thomae Gmbh, 7950 Biberach Substituierte 5,11-dihydro-6h-dibenz(b,e)azepin-6-one, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3531682A1 (de) * 1985-09-05 1987-03-12 Thomae Gmbh Dr K (+)-6-chlor-5,10-dihydro-5-((1-methyl-4- piperidinyl)acetyl)-11h-dibenzo(b,e)(1,4) diazepin-11-on, seine isolierung und verwendung als arzneimittel
US4719149A (en) 1986-02-28 1988-01-12 Minnesota Mining And Manufacturing Company Method for priming hard tissue
DE3726908A1 (de) * 1987-08-13 1989-02-23 Thomae Gmbh Dr K Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3738980A1 (de) * 1987-11-17 1989-05-24 Thomae Gmbh Dr K Mittel zur behandlung von ischaemischen herzerkrankungen
DE3838912A1 (de) * 1988-11-17 1990-05-23 Thomae Gmbh Dr K Mittel zur behandlung von akuten und chronischen obstruktiven atemwegserkrankungen
BRPI0006503B1 (pt) * 2000-02-04 2017-05-09 Biolab Sanus Farmacêutica Ltda composição em forma de gel, creme, aerosol, spray, líquida e liofilizada de substância carreadora de produtos à base de papaína
WO2004058700A2 (en) * 2002-12-20 2004-07-15 Merck & Co., Inc. Mitotic kinesin inhibitors
WO2007056388A2 (en) * 2005-11-07 2007-05-18 The General Hospital Corporation Compositions and methods for modulating poly (adp-ribose) polymerase activity
CN103980212A (zh) * 2014-05-15 2014-08-13 南京工业大学 一锅法合成二苯二氮卓杂环衍生物的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1795176C3 (de) * 1968-08-20 1974-10-24 Dr. Karl Thomae Gmbh, 7950 Biberach hT-substituierte 5-Aminoacetyl-5,10-dihydro-l lH-dibenzo eckige Klammer auf b,e eckige Klammer zu eckige Klammer auf 1,4 eckige Klammer zu diazepin-11one und Verfahren zu ihrer Herstellung
IL61642A0 (en) * 1979-12-20 1981-01-30 Beecham Group Ltd Aniline derivatives,their preparation and pharmalceutical compositions containing them
DE3028001A1 (de) * 1980-07-24 1982-02-18 Dr. Karl Thomae Gmbh, 7950 Biberach Neue, in 5-stellung substituierte 5,10-dihydro-11h-dibenzo (b,e)(1,4) diazepin-11-one, verfahren zu ihrer herstellung und diese verbindung enthaltende arzneimittel

Also Published As

Publication number Publication date
JPH0316953B2 (es) 1991-03-06
GB8303102D0 (en) 1983-03-09
ES519531A0 (es) 1984-03-01
CS78483A2 (en) 1985-07-16
IE830219L (en) 1983-08-06
US4447434A (en) 1984-05-08
FI75818B (fi) 1988-04-29
FI830337L (fi) 1983-08-07
NO158623B (no) 1988-07-04
DD207200A1 (de) 1984-02-22
GB2115411A (en) 1983-09-07
SU1301314A3 (ru) 1987-03-30
ES8501390A1 (es) 1984-11-16
GR78060B (es) 1984-09-26
IE54552B1 (en) 1989-11-22
PT76198A (de) 1983-03-01
DK48983A (da) 1983-08-07
ES526727A0 (es) 1984-11-16
NZ203192A (en) 1986-02-21
JPS58146581A (ja) 1983-09-01
NO830386L (no) 1983-08-08
DE3204157A1 (de) 1983-08-11
ES526729A0 (es) 1984-11-16
PL240437A1 (en) 1984-10-08
IL67836A (en) 1986-01-31
FI75818C (fi) 1988-08-08
ES8501387A1 (es) 1984-11-16
GB2115411B (en) 1985-07-31
CA1189507A (en) 1985-06-25
ZA83774B (en) 1984-10-31
DK48983D0 (da) 1983-02-04
KR840003620A (ko) 1984-09-15
NO158623C (no) 1988-10-12
ATE17002T1 (de) 1986-01-15
AU557463B2 (en) 1986-12-24
ES526728A0 (es) 1984-11-16
EP0085892A1 (de) 1983-08-17
FI830337A0 (fi) 1983-02-01
ES8403120A1 (es) 1984-03-01
HU190708B (en) 1986-10-28
KR900005278B1 (ko) 1990-07-27
CS241138B2 (en) 1986-03-13
ES526726A0 (es) 1984-11-16
ES8501389A1 (es) 1984-11-16
EP0085892B1 (de) 1985-12-18
IL67836A0 (en) 1983-06-15
PL138523B1 (en) 1986-09-30
HK90189A (en) 1989-11-24
PT76198B (de) 1986-01-27
DE3361504D1 (en) 1986-01-30
AU1112383A (en) 1983-08-11

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303