ES8406846A1 - Procedimiento para la obtencion de acidos 1-ciclopropil-6-fluor-1,4-dihidro-4-oxo-7-(alquil-piperazinil)-3-quinolincarboxilicos - Google Patents

Procedimiento para la obtencion de acidos 1-ciclopropil-6-fluor-1,4-dihidro-4-oxo-7-(alquil-piperazinil)-3-quinolincarboxilicos

Info

Publication number
ES8406846A1
ES8406846A1 ES528495A ES528495A ES8406846A1 ES 8406846 A1 ES8406846 A1 ES 8406846A1 ES 528495 A ES528495 A ES 528495A ES 528495 A ES528495 A ES 528495A ES 8406846 A1 ES8406846 A1 ES 8406846A1
Authority
ES
Spain
Prior art keywords
cyclopropyl
oxo
alkyl
quinoline
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES528495A
Other languages
English (en)
Spanish (es)
Other versions
ES528495A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6182078&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8406846(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES528495A0 publication Critical patent/ES528495A0/es
Publication of ES8406846A1 publication Critical patent/ES8406846A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
ES528495A 1982-12-29 1983-12-28 Procedimiento para la obtencion de acidos 1-ciclopropil-6-fluor-1,4-dihidro-4-oxo-7-(alquil-piperazinil)-3-quinolincarboxilicos Expired ES8406846A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823248506 DE3248506A1 (de) 1982-12-29 1982-12-29 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(alkyl-1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel

Publications (2)

Publication Number Publication Date
ES528495A0 ES528495A0 (es) 1984-09-01
ES8406846A1 true ES8406846A1 (es) 1984-09-01

Family

ID=6182078

Family Applications (1)

Application Number Title Priority Date Filing Date
ES528495A Expired ES8406846A1 (es) 1982-12-29 1983-12-28 Procedimiento para la obtencion de acidos 1-ciclopropil-6-fluor-1,4-dihidro-4-oxo-7-(alquil-piperazinil)-3-quinolincarboxilicos

Country Status (20)

Country Link
US (1) US4544658A (forum.php)
EP (1) EP0113093B1 (forum.php)
JP (1) JPS59130880A (forum.php)
KR (2) KR870000901B1 (forum.php)
AT (1) ATE19877T1 (forum.php)
AU (1) AU560153B2 (forum.php)
CA (1) CA1218070A (forum.php)
DD (1) DD216016A5 (forum.php)
DE (2) DE3248506A1 (forum.php)
DK (1) DK160989C (forum.php)
ES (1) ES8406846A1 (forum.php)
FI (1) FI79102C (forum.php)
GR (1) GR79445B (forum.php)
HU (1) HU191392B (forum.php)
IE (1) IE56460B1 (forum.php)
IL (1) IL70539A (forum.php)
NO (1) NO162236C (forum.php)
NZ (1) NZ206705A (forum.php)
PH (3) PH20545A (forum.php)
ZA (1) ZA839646B (forum.php)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5468861A (en) * 1984-06-04 1995-11-21 Bayer Aktiengesellschaft 8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and alkyl esters thereof
DE3420798A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-(3-aryl-l-piperazinyl)- sowie 7-(3-cyclohexyl-l-piperazinyl)-3-chinoloncarbonsaeuren
DE3420743A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3420770A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-(3-oxo-1-piperazinyl)-3-chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3426483A1 (de) * 1984-07-18 1986-01-30 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von halogenierten chinoloncarbonsaeuren
DE3435392A1 (de) * 1984-09-27 1986-04-03 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von 2,4-dichlor-5-fluor-benzoesaeure
JPS6191183A (ja) * 1984-10-11 1986-05-09 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
US4636506A (en) * 1984-12-06 1987-01-13 Pfizer, Inc. 7-heterocyclic-1,4-dihydroquinolones
JPS6212760A (ja) * 1984-12-14 1987-01-21 Dai Ichi Seiyaku Co Ltd １−（２−ハロゲノシクロプロピル）キノリンカルボン酸誘導体
DE3508816A1 (de) * 1985-01-10 1986-07-10 Bayer Ag, 5090 Leverkusen 6,7-disubstituierte 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphtyridin-3-carbonsaeuren
DE3509546A1 (de) * 1985-03-16 1986-09-25 Bayer Ag, 5090 Leverkusen 7-amino-1-(subst.cyclopropyl)-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
AU594983B2 (en) 1985-10-29 1990-03-22 Dainippon Pharmaceutical Co. Ltd. Novel quinoline derivatives and processes for preparation thereof
DE3617803A1 (de) * 1985-11-07 1987-11-19 Bayer Ag Verwendung von gyrasehemmern zur dekontamination von mycoplasma-infizierten zellkulturen
DE3542002A1 (de) * 1985-11-28 1987-06-04 Bayer Ag 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4977154A (en) * 1985-12-12 1990-12-11 Warner-Lambert Company 5-amino and 5-hydroxy-6-fluoroquinolones as antibacterial agents
US5210193A (en) * 1986-01-17 1993-05-11 American Cyanamid Company Piperazine derivatives
US4940710A (en) * 1986-01-17 1990-07-10 American Cyanamid Company 7-(substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
JPS62215572A (ja) * 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
IL88003A (en) * 1987-10-16 1992-11-15 Dainippon Pharmaceutical Co Quinoline derivatives,their preparation and pharmaceutical compositions containing them
US5164392A (en) * 1987-10-16 1992-11-17 Dainippon Pharmaceutical Co., Ltd. Quinoline derivatives and antibacterial agent containing them
CN1152916A (zh) * 1994-07-18 1997-06-25 宇部兴产株式会社 三氟甲基喹啉羧酸衍生物
JP3449658B2 (ja) * 1994-12-21 2003-09-22 杏林製薬株式会社 安定性に優れた８−アルコキシキノロンカルボン酸水和物並びにその製造方法
BR9812644B1 (pt) 1997-09-15 2010-07-13 quinolonas antimicrobianas, composição farmacêutica e uso das mesmas.
US6387928B1 (en) 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
KR100821894B1 (ko) * 2004-07-02 2008-04-16 주식회사 코오롱 항균 염료 및 그를 이용한 항균 섬유
JP5097967B2 (ja) * 2006-03-28 2012-12-12 タイゲン バイオテクノロジー カンパニー，リミテッド リンゴ酸塩類、及び（３ｓ，５ｓ）−７−［３−アミノ−５−メチルーピペリジニル］−１−シクロプロピル−１，４−ジヒドロ−８−メトキシ−４−オキソ−３−キノリンカルボン酸の多形体類
KR20110082635A (ko) * 2006-03-28 2011-07-19 워너 칠콧 컴퍼니 엘엘씨 퀴놀론 중간체를 제조하기 위한 커플링 방법
KR101030202B1 (ko) * 2006-03-28 2011-04-22 워너 칠콧 컴퍼니 엘엘씨 퀴놀론 중간체의 제조를 위한 수소화물 환원 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3149104A (en) * 1961-01-03 1964-09-15 Sterling Drug Inc 4-hydroxy-7-styryl-1, 8-naphthyridine-3-carboxylic acids and esters
DE2808070A1 (de) * 1978-02-24 1979-08-30 Bayer Ag Verfahren zur herstellung von 4-pyridon-3-carbonsaeuren und/oder deren derivaten
DE3033157A1 (de) * 1980-09-03 1982-04-01 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3142854A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel

Also Published As

Publication number Publication date
PH20545A (en) 1987-02-09
EP0113093A1 (de) 1984-07-11
DK604083A (da) 1984-06-30
US4544658A (en) 1985-10-01
JPH0323549B2 (forum.php) 1991-03-29
IL70539A (en) 1987-08-31
ZA839646B (en) 1984-08-29
FI834806A0 (fi) 1983-12-27
FI834806L (fi) 1984-06-30
NO162236C (no) 1989-11-29
DK604083D0 (da) 1983-12-28
NZ206705A (en) 1986-01-24
IE56460B1 (en) 1991-08-14
DE3363608D1 (en) 1986-06-26
AU2251083A (en) 1984-07-05
KR870001003B1 (ko) 1987-05-18
DK160989C (da) 1991-10-28
HU191392B (en) 1987-02-27
NO162236B (no) 1989-08-21
KR870000901B1 (ko) 1987-05-04
GR79445B (forum.php) 1984-10-30
DE3248506A1 (de) 1984-07-05
ATE19877T1 (de) 1986-06-15
JPS59130880A (ja) 1984-07-27
CA1218070A (en) 1987-02-17
FI79102B (fi) 1989-07-31
ES528495A0 (es) 1984-09-01
IL70539A0 (en) 1984-03-30
IE833034L (en) 1984-06-29
FI79102C (fi) 1989-11-10
EP0113093B1 (de) 1986-05-21
DK160989B (da) 1991-05-13
PH22453A (en) 1988-09-12
AU560153B2 (en) 1987-04-02
KR840006990A (ko) 1984-12-04
NO834632L (no) 1984-07-02
DD216016A5 (de) 1984-11-28
PH21478A (en) 1987-10-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20020506