ES8406196A1 - Polynuclear iron (III) complexes - Google Patents
Polynuclear iron (III) complexesInfo
- Publication number
- ES8406196A1 ES8406196A1 ES526481A ES526481A ES8406196A1 ES 8406196 A1 ES8406196 A1 ES 8406196A1 ES 526481 A ES526481 A ES 526481A ES 526481 A ES526481 A ES 526481A ES 8406196 A1 ES8406196 A1 ES 8406196A1
- Authority
- ES
- Spain
- Prior art keywords
- acid
- iii
- iron
- equivalents
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical class [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 title abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 6
- 239000002253 acid Substances 0.000 abstract 3
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 abstract 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 2
- 238000001256 steam distillation Methods 0.000 abstract 2
- UOQHWNPVNXSDDO-UHFFFAOYSA-N 3-bromoimidazo[1,2-a]pyridine-6-carbonitrile Chemical compound C1=CC(C#N)=CN2C(Br)=CN=C21 UOQHWNPVNXSDDO-UHFFFAOYSA-N 0.000 abstract 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 abstract 1
- 229920002307 Dextran Polymers 0.000 abstract 1
- JYTUSYBCFIZPBE-UHFFFAOYSA-N Maltobionic acid Natural products OC(=O)C(O)C(O)C(C(O)CO)OC1OC(CO)C(O)C(O)C1O JYTUSYBCFIZPBE-UHFFFAOYSA-N 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- MSNWSDPPULHLDL-UHFFFAOYSA-K ferric hydroxide Chemical compound [OH-].[OH-].[OH-].[Fe+3] MSNWSDPPULHLDL-UHFFFAOYSA-K 0.000 abstract 1
- 239000000174 gluconic acid Substances 0.000 abstract 1
- 235000012208 gluconic acid Nutrition 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
- PVFSDGKDKFSOTB-UHFFFAOYSA-K iron(3+);triacetate Chemical compound [Fe+3].CC([O-])=O.CC([O-])=O.CC([O-])=O PVFSDGKDKFSOTB-UHFFFAOYSA-K 0.000 abstract 1
- JYTUSYBCFIZPBE-AMTLMPIISA-N lactobionic acid Chemical compound OC(=O)[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O JYTUSYBCFIZPBE-AMTLMPIISA-N 0.000 abstract 1
- 229940099563 lactobionic acid Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000001954 sterilising effect Effects 0.000 abstract 1
- 238000005292 vacuum distillation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A process for the preparation of a solution for pharmaceutical use of an electroneutral, polynuclear iron (III) complex comprising dissolving in acetic acid freshly precipitated iron (III) hydroxide, washed anion- free reacting iron (III) acetate thus obtained either with 0.25 to 0.5 equivalents of a sugar acid and 0.25 to 0.5 equivalents of dextran, or with 0.5 to 1.0 equivalents of a sugar acid removing the acetic acid thus formed by steam distillation, steam distillation being continued until the solution has a pH of 4.5 to 5.0 adjusting the iron concentration, where necessary, to the required figure by vacuum distillation and, if desired, sterilizing the solution and/or adding additives and/or adjuvants. The sugar acid is preferably lactobionic acid, gluconic acid or maltobionic acid.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU328182A HU187167B (en) | 1982-10-15 | 1982-10-15 | Process for producing pharmaceutical solution of new type polynuclear iron/iii/ mixed complex activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8406196A1 true ES8406196A1 (en) | 1984-08-01 |
| ES526481A0 ES526481A0 (en) | 1984-08-01 |
Family
ID=10963435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES526481A Granted ES526481A0 (en) | 1982-10-15 | 1983-10-14 | PROCEDURE FOR OBTAINING AN INJECTABLE SOLUTION BASED ON A MIXED COMPLEX OF POLYNUCLEAR AND IRON-ELECTRONIC IRON IRON |
Country Status (11)
| Country | Link |
|---|---|
| AT (1) | AT385655B (en) |
| BE (1) | BE897980A (en) |
| BG (1) | BG49708A3 (en) |
| DE (1) | DE3337506A1 (en) |
| DK (1) | DK476583A (en) |
| ES (1) | ES526481A0 (en) |
| FI (1) | FI80830C (en) |
| FR (1) | FR2534589B1 (en) |
| GB (1) | GB2129821B (en) |
| HU (1) | HU187167B (en) |
| SE (1) | SE462140B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3728814A1 (en) * | 1987-08-28 | 1989-03-30 | Lentia Gmbh | SOLUTION FOR USE AS A RINSING LIQUID IN THE DESTRUCTION OF NON-BODY DEPOSITS IN HUMAN AND ANIMAL TISSUES OR BODIES |
| DE4445772A1 (en) * | 1993-12-27 | 1995-06-29 | Loeser Thomas Dr Ing | Determn. of required dosage of trace elements and minerals in medicaments |
| DE19712493A1 (en) * | 1997-03-25 | 1998-10-01 | Univ Karlsruhe | Pharmaceutical composition comprises iron calcium poly:ate |
| DE10249552A1 (en) | 2002-10-23 | 2004-05-13 | Vifor (International) Ag | Water-soluble iron-carbohydrate complexes, their preparation and medicaments containing them |
| US20040170724A1 (en) * | 2003-02-28 | 2004-09-02 | Kraft Foods Holdings, Inc. | Mineral complexes of lactobionic acid and method of using for mineral fortification of food products |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE862482C (en) * | 1950-05-14 | 1953-01-12 | Merck Chem Fab E | Process for the preparation of durable, injectable solutions of salts of trivalent iron |
| DE938502C (en) * | 1953-02-27 | 1956-02-02 | Benger S Ltd | Method of making a colloidal iron preparation |
| GB978485A (en) * | 1960-10-26 | 1964-12-23 | Astra Apotekarnes Kem Fab | Iron preparations for intramuscular injection |
| DE1293144B (en) * | 1964-11-04 | 1969-04-24 | Hausmann Ag Labor | Process for the production of complex compounds of iron with sorbitol, gluconic acid and an oligosaccharide |
| DK122890B (en) * | 1964-12-29 | 1972-04-24 | J Reumert | Process for the preparation of ferric hydroxide dextran complexes. |
| DE1617463A1 (en) * | 1965-11-20 | 1971-04-08 | Bayer Ag | Process for the manufacture of injectable colloidal iron preparations |
| GB1149137A (en) * | 1966-10-28 | 1969-04-16 | H C F Porsche K G Ing | Screw outboard drive for boats |
| AT279048B (en) * | 1967-07-04 | 1970-02-25 | Pharmazeutische Fabrik Montavit Gmbh | Process for the preparation of new, soluble and stable organic iron (III) complex compounds and injection solutions thereof |
| DE2527158A1 (en) * | 1975-06-18 | 1976-12-23 | Herz Eberhard | MEDICINAL PRODUCTS FOR THE TREATMENT OF INFECTIOUS DISEASES AND INFLAMMATION IN HUMAN AND VETERINAL MEDICINE THAT CANNOT BE DETECTED BY MICROORGANISMS |
| JPS6039681B2 (en) * | 1976-01-01 | 1985-09-07 | 日本臓器製薬株式会社 | Dextrin-citric acid-ferric polynuclear complex and parenteral iron preparation containing the complex |
| GB2006243B (en) * | 1977-09-29 | 1982-07-14 | Atomic Energy Authority Uk | Compounds |
| DE3026868C2 (en) * | 1980-07-16 | 1986-03-13 | Laboratorien Hausmann AG, St. Gallen | Process for the preparation of iron (III) hydroxide-dextran complexes and pharmaceutical sterile aqueous solution containing them |
-
1982
- 1982-10-15 HU HU328182A patent/HU187167B/en not_active IP Right Cessation
-
1983
- 1983-10-12 AT AT363983A patent/AT385655B/en not_active IP Right Cessation
- 1983-10-12 FI FI833707A patent/FI80830C/en not_active IP Right Cessation
- 1983-10-13 BE BE0/211691A patent/BE897980A/en not_active IP Right Cessation
- 1983-10-14 DK DK476583A patent/DK476583A/en not_active Application Discontinuation
- 1983-10-14 BG BG6264983A patent/BG49708A3/en unknown
- 1983-10-14 FR FR8316377A patent/FR2534589B1/en not_active Expired
- 1983-10-14 ES ES526481A patent/ES526481A0/en active Granted
- 1983-10-14 GB GB08327633A patent/GB2129821B/en not_active Expired
- 1983-10-14 SE SE8305665A patent/SE462140B/en not_active IP Right Cessation
- 1983-10-14 DE DE19833337506 patent/DE3337506A1/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| BE897980A (en) | 1984-01-30 |
| GB2129821B (en) | 1986-02-19 |
| FI833707A0 (en) | 1983-10-12 |
| GB8327633D0 (en) | 1983-11-16 |
| HU187167B (en) | 1985-11-28 |
| FI80830C (en) | 1990-08-10 |
| SE8305665D0 (en) | 1983-10-14 |
| DK476583D0 (en) | 1983-10-14 |
| FI80830B (en) | 1990-04-30 |
| SE8305665L (en) | 1984-04-16 |
| DK476583A (en) | 1984-04-16 |
| BG49708A3 (en) | 1992-01-15 |
| FI833707A (en) | 1984-04-16 |
| GB2129821A (en) | 1984-05-23 |
| DE3337506A1 (en) | 1984-04-19 |
| SE462140B (en) | 1990-05-14 |
| ATA363983A (en) | 1987-10-15 |
| DE3337506C2 (en) | 1991-07-04 |
| AT385655B (en) | 1988-05-10 |
| FR2534589B1 (en) | 1988-12-16 |
| ES526481A0 (en) | 1984-08-01 |
| FR2534589A1 (en) | 1984-04-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |
Effective date: 19960506 |