GB1062434A - Process for isolating -antitrypsin - Google Patents

Process for isolating -antitrypsin

Info

Publication number
GB1062434A
GB1062434A GB24601/64A GB2460164A GB1062434A GB 1062434 A GB1062434 A GB 1062434A GB 24601/64 A GB24601/64 A GB 24601/64A GB 2460164 A GB2460164 A GB 2460164A GB 1062434 A GB1062434 A GB 1062434A
Authority
GB
United Kingdom
Prior art keywords
antitrypsin
isolating
carboxyethylated
molarity
dextrans
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB24601/64A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Publication of GB1062434A publication Critical patent/GB1062434A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J47/00—Ion-exchange processes in general; Apparatus therefor
    • B01J47/014—Ion-exchange processes in general; Apparatus therefor in which the adsorbent properties of the ion-exchanger are involved, e.g. recovery of proteins or other high-molecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

a 1-antitrypsin is isolated from animal body fluids e.g blood serum and/or purified by contacting an aqueous solution containing a 1-antitrypsin at a molarity of from 0.005 to 0.05 and having a pH in the range 5.0 to 5.5 with a cation-exchanger having carboxymethyl groups and subsequently separating the a 1-antitrypsin therefrom. Specified exchangers are carboxymethyl cellulose and cross-linked carboxyethylated dextrans. The eluted a 1-antitrypsin may be separated from any buffer present by dialysis and freeze-dried to give a solid product.
GB24601/64A 1963-06-12 1964-06-12 Process for isolating -antitrypsin Expired GB1062434A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEB72263A DE1189674B (en) 1963-06-12 1963-06-12 Method for the isolation of alpha-antitrypsin

Publications (1)

Publication Number Publication Date
GB1062434A true GB1062434A (en) 1967-03-22

Family

ID=6977373

Family Applications (1)

Application Number Title Priority Date Filing Date
GB24601/64A Expired GB1062434A (en) 1963-06-12 1964-06-12 Process for isolating -antitrypsin

Country Status (7)

Country Link
US (1) US3293236A (en)
AT (1) AT255027B (en)
BE (1) BE649238A (en)
CH (1) CH443561A (en)
DE (1) DE1189674B (en)
GB (1) GB1062434A (en)
NL (1) NL6406622A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0067293A2 (en) * 1981-05-01 1982-12-22 Medical Research Institute of San Francisco Method for isolating alpha-1-antitrypsin

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3176491D1 (en) * 1980-03-05 1987-11-26 Miles Lab Pasteurized therapeutically active protein compositions
US5610285A (en) * 1994-08-24 1997-03-11 Bayer Corporation Purification of α-1 proteinase inhibitor using novel chromatographic separation conditions
AU6884396A (en) 1995-09-07 1997-03-27 Ppl Therapeutics (Scotland) Ltd Purification of alpha-1 proteinase inhibitor
US6093804A (en) * 1998-09-24 2000-07-25 American National Red Cross Method for purification of alpha-1 proteinase inhibitor
US6462180B1 (en) 1999-11-24 2002-10-08 Bayer Corporation Method of preparing α-1 proteinase inhibitor
US7777006B2 (en) 2002-12-31 2010-08-17 Csl Behring L.L.C. Method for purification of alpha-1-antitrypsin

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3002823A (en) * 1958-04-16 1961-10-03 Pharmacia Ab Process of separating materials having different molecular weights and dimensions
US3042667A (en) * 1959-03-10 1962-07-03 Pharmacia Ab Process for producing dextran derivatives and products resulting therefrom

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0067293A2 (en) * 1981-05-01 1982-12-22 Medical Research Institute of San Francisco Method for isolating alpha-1-antitrypsin
EP0067293A3 (en) * 1981-05-01 1984-01-04 Medical Res Inst San Francisco Method for isolating alpha-1-antitrypsin

Also Published As

Publication number Publication date
US3293236A (en) 1966-12-20
CH443561A (en) 1967-09-15
NL6406622A (en) 1964-12-14
BE649238A (en) 1964-12-14
DE1189674B (en) 1965-03-25
AT255027B (en) 1967-06-26

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