DE1617463A1 - Process for the manufacture of injectable colloidal iron preparations - Google Patents

Description

FARBENFABRIKEN BAYER AG

LEVERKUSEN-Biyerwerk 26 NOV. 1969

P 16 17 463-3 p «tent-Ab« iiung si / Sc

Process for the manufacture of injectable colloidal iron preparations

It is known that one can produce injectable colloidal egg preparations with polysaccharides in alkaline solution in the presence of hydrogen peroxide Ferric salts are heated and the resulting polysacharide-iron complex, optionally by adding chelate-forming hydroxy acids "or their salts, in brings aqueous solution.

It has now been found that a degradation of the polysaccharides with hydrogen peroxide also takes place in neutral or weakly acidic solution, and that such polymer homologs which are suitable for the production of colloidal iron preparations.

It is expedient to proceed in such a way that an aqueous solution of the polysaccharide is mixed with hydrogen peroxide and heated to the boil until the degradation has reached the desired level. The solution becomes during the breakdown

generally angry at chess. For extremely acid-sensitive Polysaccharides »such as Laevan, it is therefore advisable to to buffer the solutions before dismantling.

As described in the main patent, the degraded polysaccharides are reacted with ferric salts at a pH value that should be higher than 8. _{Inorganic bases f,} such as sodium hydroxide solution or potassium hydroxide solution, or organic bases _t such as triethylamine, for example, are suitable for setting the pH value above 8. The products of the method according to the invention are suitable for therapy with trivalent iron, especially in veterinary medicine.

example 1

16.2 g of water-soluble starch are dissolved in 400 ml of water and treated with 2.5 ml of 30% hydrogen peroxide. The intestine is heated to the boil for 7 hours, mixed with 40 ml of triethylamine and 70 ml of a 30% ferric chloride solution are added dropwise. The mixture is further stirred for one hour at about 8O ⁰ C, clarified by centrifugation, and precipitated with methanol. After a single reprecipitation from methanol, an iron-starch complex is obtained. Yield 12.8 g; Iron content: 24.8 <fi.

40 g of the iron-starch complex are dissolved in a little warm water and made up to 100 ecm after adjusting the pH to 6.3. Then it is made isotonic with table salt. Sterilization is carried out with 1/2-hour heating at 105 ⁰ C, οine injectable solution of the iron complex is obtained with a content of 100 mg / ml of iron.

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Example 2

16.2 g of soluble starch are dissolved in 400 ml of water and treated with 10 ml of 3Q hydrogen peroxide. The solution is heated to boiling for 2 1/2 hours and worked up as in Example 1.
Yield: 14.0 g / Iron content: 25.4% .

Example 3

-16.2 g of native Laevan are * in 400 ml of m / 15 acetate buffer dissolved from pH 5.5 and with 5.0 ecm 30- $ hydrogen peroxide offset. The batch is heated to boiling for three hours and worked up as in Example 1. Yield: 13t 2 g; Iron content: $ 25.8.

L e A 1 0 130 "■ ·. - 3 -

109815/1814

Claims (1)

Patent entitlement Process for the preparation of injectable colloidal Iron preparations, characterized in that nan polysaccharides heated in a neutral or weakly acidic reaction with hydrogen peroxide, the reaction mixture at a pH value above 8 is heated with ferric salts and the polysaccharide-iron complex is isolated in the usual way. Le A 10 130 - 4 - 109816/1 * 14