DE261875C - - Google Patents
Info
- Publication number
- DE261875C DE261875C DENDAT261875D DE261875DA DE261875C DE 261875 C DE261875 C DE 261875C DE NDAT261875 D DENDAT261875 D DE NDAT261875D DE 261875D A DE261875D A DE 261875DA DE 261875 C DE261875 C DE 261875C
- Authority
- DE
- Germany
- Prior art keywords
- salts
- silver
- compounds
- acid
- urea
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000002253 acid Substances 0.000 claims description 8
- 150000001447 alkali salts Chemical class 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 4
- LBVGBJMIMFRUSV-UHFFFAOYSA-N [C].[Hg] Chemical class [C].[Hg] LBVGBJMIMFRUSV-UHFFFAOYSA-N 0.000 claims description 3
- 239000003513 alkali Substances 0.000 claims description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 3
- 239000004202 carbamide Substances 0.000 claims 3
- NDVLTYZPCACLMA-UHFFFAOYSA-N silver oxide Chemical compound [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 claims 2
- RTZOEZPIPKDVLT-UHFFFAOYSA-N 5,5-diethyl-1,3-diazinane-2,4,6-trione;sodium Chemical compound [Na].CCC1(CC)C(=O)NC(=O)NC1=O RTZOEZPIPKDVLT-UHFFFAOYSA-N 0.000 claims 1
- CKUAXEQHGKSLHN-UHFFFAOYSA-N [C].[N] Chemical class [C].[N] CKUAXEQHGKSLHN-UHFFFAOYSA-N 0.000 claims 1
- 150000008065 acid anhydrides Chemical class 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 150000003949 imides Chemical class 0.000 claims 1
- 229910001923 silver oxide Inorganic materials 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 4
- 150000003378 silver Chemical class 0.000 description 4
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229910052709 silver Inorganic materials 0.000 description 3
- 239000004332 silver Substances 0.000 description 3
- ALRHLSYJTWAHJZ-UHFFFAOYSA-N 3-hydroxypropionic acid Chemical compound OCCC(O)=O ALRHLSYJTWAHJZ-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 2
- 229910052753 mercury Inorganic materials 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 229910001961 silver nitrate Inorganic materials 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical compound O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 description 2
- ZYDVNTYVDVZMKF-UHFFFAOYSA-N [Cl].[Ag] Chemical compound [Cl].[Ag] ZYDVNTYVDVZMKF-UHFFFAOYSA-N 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 229960002319 barbital Drugs 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 125000002524 organometallic group Chemical group 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- RGHFKWPGWBFQLN-UHFFFAOYSA-M sodium;5,5-diethylpyrimidin-3-ide-2,4,6-trione Chemical compound [Na+].CCC1(CC)C([O-])=NC(=O)NC1=O RGHFKWPGWBFQLN-UHFFFAOYSA-M 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229960002317 succinimide Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/10—Mercury compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
KAISERLICHESIMPERIAL
PATENTAMT.PATENT OFFICE.
PATENTSCHRIFTPATENT LETTERING
Ig 261875 KLASSE 12 o. GRUPPEIg 261875 CLASS 12 or GROUP
Es wurde gefunden, daß die Silbersalze in Wasser unlöslicher substituierter Quecksilberkohlenstoffverbindungen mit den Alkalisalzen von stickstoffhaltigen Verbindungen mit am-S photerem oder schwach saurem Charakter beständige, in Wasser leicht lösliche Additionsderivate bilden. Diese Körper haben infolge ihres Gehaltes an Silber und metallorganisch gebundenem Quecksilber wertvolle therapeutische Eigenschaften. Insbesondere sind sie dadurch ausgezeichnet, daß sie mit verdünnten Kochsalzlösungen, wie sie in den Körpersäften vorliegen, keinen Niederschlag, sondern kolloidales Chlorsilber bilden, das sich tagelang in Lösung hält. .It has been found that the silver salts are water-insoluble substituted carbon mercury compounds with the alkali salts of nitrogenous compounds with am-S form stable, easily soluble addition derivatives in water. These bodies have a result their content of silver and organometallic mercury are valuable therapeutic Properties. In particular, they are distinguished in that they are diluted with Saline solutions, as they are in the body fluids, do not precipitate, but rather Form colloidal silver that stays in solution for days. .
533 Teile oxymercurithymoxylessigsaures SiI-ber, erhalten durch Umsetzen des Natronsalzes der Säure mit Silbernitrat, werden in 3000 Teilen Wasser suspendiert und mit 420 Teilen diäthylbarbitursaurem Natrium versetzt. Nach kurzem Umrühren tritt Lösung ein, die im luftverdünnten Raum zur Trockne gebracht wird. Das so erhaltene Salz ist in Wasser gut löslich. Verdünnte Kochsalzlösung gibt keine Fällung von Chlorsilber. Gegep Alkali ist die Verbindung beständig. Säuren bewirken Spaltung in die entsprechenden Silbersalze und in Oxymercurithymoxylessigsäureanhydrid. 533 parts of oxymercurithymoxylacetic acid SiI-ber, obtained by reacting the sodium salt of the acid with silver nitrate, are suspended in 3000 parts of water and with 420 parts of sodium diethylbarbiturate were added. After brief stirring, solution appears which is brought to dryness in the air-diluted room. The salt thus obtained is in Well soluble in water. Diluted saline does not result in precipitation of silver chlorine. Gegep Alkali the connection is resistant. Acids cause splitting into the corresponding ones Silver salts and in oxymercurithymoxyacetic anhydride.
44 Teile oxymercuribenzoesaures Silber, erhalten durch Umsetzen des Natronsalzes mit Silbernitrat, werden in 250 Teilen Wasser suspendiert und mit 10 Teilen Succinimid versetzt. Auf Zusatz von 100 Teilen Normal-Natronlauge tritt fast vollständige Lösung ein. Durch Eindampfen im luftverdünnten Raum wird die neue Doppelverbindung kristallinisch abgeschieden. Sie ist in Wasser löslich, fast unlöslich in organischen Lösungsmitteln. Durch Säuren wird die Verbindung versetzt.44 parts of oxymercuribenzoic acid silver, obtained by reacting the sodium salt with Silver nitrate are suspended in 250 parts of water and mixed with 10 parts of succinimide. Almost complete dissolution occurs on addition of 100 parts of normal sodium hydroxide solution a. The new double compound becomes crystalline through evaporation in the air-diluted room deposited. It is soluble in water, almost insoluble in organic solvents. The compound is displaced by acids.
An Stelle des oxymercurithymoxylessigsaureh Silbers können Silbersalze jeder beliebigen aromatischen oder aliphatischen Säure, die das Quecksilber in Kohlenstoffbindung enthält, Anwendung finden, wie die der Oxymercurisalicylsäure, Oxymercuri-o-chlorbenzoesäure, a-Oxymercuri-6-phenylmethylätherhydracrylsäure (Ber. 43, S. 695—699), Oxyquecksilberessigsäure (Patent 213371) usw.; an Stelle der fertig gebildeten Silbersalze können dieIn place of the oxymercurithymoxylacetic acid silver, any silver salts can be used aromatic or aliphatic acid, which contains the mercury in carbon bond, Find application, such as those of oxymercuric salicylic acid, oxymercuri-o-chlorobenzoic acid, α-Oxymercuri-6-phenylmethyl ether hydracrylic acid (Ber. 43, pp. 695-699), oxymercuric acetic acid (Patent 213371) etc .; instead of the completely formed silver salts, the
/■/ ■
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE261875C true DE261875C (en) |
Family
ID=519395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DENDAT261875D Active DE261875C (en) |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE261875C (en) |
-
0
- DE DENDAT261875D patent/DE261875C/de active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE261875C (en) | ||
| DE255030C (en) | ||
| DE82951C (en) | ||
| DE405017C (en) | Process for the preparation of complex silver compounds of sulfur-containing carboxylic acids | |
| DE208189C (en) | ||
| DE633786C (en) | Process for the preparation of complex compounds of 1,3-dimethylxanthine | |
| DE185197C (en) | ||
| DE172932C (en) | ||
| DE392656C (en) | Process for the preparation of compounds of cystine and cysteine with heavy metals, which are easily soluble in water | |
| DE129031C (en) | Process for the preparation of easily soluble in water, resistant alkali salts of the decomposition products resulting from the alkaline hydrolysis of the native protein | |
| DE694100C (en) | Process for the production of metal compounds | |
| DE655684C (en) | Process for the production of metal compounds of keratinic acids | |
| AT67673B (en) | Process for the preparation of alkaline albumose silver compounds. | |
| DE139907C (en) | ||
| DE548512C (en) | Process for the production of easily soluble compounds of sulfosalicylic acid with silver or gold protein | |
| DE605074C (en) | Process for the preparation of compounds of sulfhydryl keratinic acid and similar reduced degradation products of keratin with organic compounds containing arsenic | |
| DE417973C (en) | Process for the production of colloidal metal solutions | |
| DE208961C (en) | ||
| DE944953C (en) | Process for the preparation of a therapeutic agent consisting of the calcium salt of Ca-ethylene diamine tetraacetic acid | |
| DE728324C (en) | Process for the preparation of a 4-oxy-3-acylaminophenylarsinic acid | |
| DE193740C (en) | ||
| DE245572C (en) | ||
| AT153216B (en) | Process for the preparation of complex gold keratin compounds. | |
| DE192473C (en) | ||
| DE1155563B (en) | Process for the production of pure preparations of the kallikrein inactivator |