DE139907C - - Google Patents
Info
- Publication number
- DE139907C DE139907C DE1901139907D DE139907DA DE139907C DE 139907 C DE139907 C DE 139907C DE 1901139907 D DE1901139907 D DE 1901139907D DE 139907D A DE139907D A DE 139907DA DE 139907 C DE139907 C DE 139907C
- Authority
- DE
- Germany
- Prior art keywords
- acid
- formaldehyde
- salts
- acids
- thymic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- WSFSSNUMVMOOMR-UHFFFAOYSA-N formaldehyde Chemical class O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 13
- 239000002253 acid Substances 0.000 claims description 7
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 239000011780 sodium chloride Substances 0.000 claims description 6
- MGSRCZKZVOBKFT-UHFFFAOYSA-N Thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 claims description 4
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 3
- 239000007857 degradation product Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 150000007523 nucleic acids Chemical class 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 150000007513 acids Chemical class 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 239000007795 chemical reaction product Substances 0.000 description 2
- 239000008098 formaldehyde solution Substances 0.000 description 2
- 241000252203 Clupea harengus Species 0.000 description 1
- 210000004940 Nucleus Anatomy 0.000 description 1
- 150000001447 alkali salts Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000019514 herring Nutrition 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 230000001225 therapeutic Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Description
KAISERLICHES Tflil IMPERIAL Tflil
PATENTAMT.PATENT OFFICE.
PATENTSCHRIFTPATENT LETTERING
r 139907 KLASSE XIp. r 139907 CLASS XIp.
phosphorsäurehaltigen Abbauprodukten.degradation products containing phosphoric acid.
Patentiert im Deutschen Reiche vom 16. November 1901 ab.Patented in the German Empire on November 16, 1901.
Es wurde gefunden, daß die Nucleinsäuren (sowohl animalischen als auch vegetabilischen Ursprungs) sowie deren phosphorsä'urehaltige Abbauprodukte, wie z. B. die Nucleothyminsäure und die Thyminsäure, die Eigenschaft besitzen, sich direkt mit Formaldehyd zu verbinden. Die so erhältlichen neuen Körper bilden gelblich weiße bis braune, unzersetzt haltbare Pulver, deren Alkalisalze in Wasser leicht löslich sind. Die wässerigen Lösungen der Salze sind in der Kälte ebenfalls beständig, dieselben spalten jedoch beim Erwärmen auf dem Wasserbade Formaldehyd ab. Dadurch, daß der Formaldehyd in diesen Präparaten verhältnismäßig locker gebunden ist, kann derselbe im Organismus leicht seine Wirkung entfalten, deshalb haben diese neuen Verbindungen sehr wertvolle therapeutische Eigenschaften.It has been found that the nucleic acids (both animal and vegetable Origin) and their degradation products containing phosphoric acid, such as B. nucleothymic acid and thymic acid, which has the property of combining directly with formaldehyde. The new bodies obtainable in this way form yellowish white to brown, undecomposed stable powders, their alkali salts in water are easily soluble. The aqueous solutions of the salts are also stable in the cold, however, they split off formaldehyde when heated on the water bath. Through this, the fact that the formaldehyde is relatively loosely bound in these preparations can do the same Easily develop their effect in the organism, so these new compounds have a lot valuable therapeutic properties.
Das neue Verfahren sei durch folgende Beispiele erläutert:The new method is illustrated by the following examples:
50 g nuclei'nsaures Natrium beliebigen Ursprungs, z. B. aus Heringssperma, werden in 250 ecm Wasser gelöst, 25 ecm 40 prozentiger wässeriger Formaldehydlösung hinzugefügt und die Mischung mehrere Stunden auf dem Wasserbade gelinde erwärmt. Das Reaktionsprodukt wird dann mit Alkohol gefällt, mit absolutem Alkohol so lange gewaschen, bis aller überschüssiger Formaldehyd entfernt ist, und dann im. Vakuum über Schwefelsäure getrocknet.50 g nuclei'nsaures sodium of any origin, z. B. from herring sperm are in 250 ecm of water dissolved, 25 ecm of 40 percent aqueous formaldehyde solution added and the mixture was gently warmed for several hours on the water bath. The reaction product is then precipitated with alcohol, washed with absolute alcohol until all excess Formaldehyde is removed, and then im. Vacuum dried over sulfuric acid.
An Stelle des Natriumsalzes lassen sich auch andere Salze oder auch die freie Säure direkt verwenden.Instead of the sodium salt, other salts or the free acid can also be used directly use.
50 g Thyminsäure werden in 250 ecm Wasser gelöst, 25 ecm 40 prozentiger wässeriger Formaldehydlösung zugefügt und mehrere Stunden bei mäßiger Wärme stehen gelassen. Darauf wird mit Alkohol gefällt, der überschüssige Formaldehyd weggewaschen und das so erhaltene Reaktionsprodukt im Vakuum über Schwefelsäure getrocknet.50 g of thymic acid are dissolved in 250 ecm of water, 25 ecm of 40 percent aqueous formaldehyde solution added and left to stand for several hours at moderate heat. The excess is then precipitated with alcohol Washed away formaldehyde and dried the reaction product obtained in vacuo over sulfuric acid.
Anstatt der Thyminsäure selbst kann man auch ihre Salze verwenden.Instead of the thymic acid itself, you can also use its salts.
In analoger Weise verfährt man bei Benutzung der Nucleothyminsäure bezw. der Salze dieser Säure.The procedure is analogous when using nucleothymic acid BEZW. of the salts this acid.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT15495D AT15495B (en) | 1901-11-15 | 1903-02-16 | Process for the preparation of formaldehyde compounds of nucleic acids and their phosphoric acid-containing degradation products. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE139907C true DE139907C (en) |
Family
ID=407618
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1901139907D Expired - Lifetime DE139907C (en) | 1901-11-15 | 1901-11-15 |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE139907C (en) |
-
1901
- 1901-11-15 DE DE1901139907D patent/DE139907C/de not_active Expired - Lifetime
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