DE134197C - - Google Patents
Info
- Publication number
- DE134197C DE134197C DE1901134197D DE134197DA DE134197C DE 134197 C DE134197 C DE 134197C DE 1901134197 D DE1901134197 D DE 1901134197D DE 134197D A DE134197D A DE 134197DA DE 134197 C DE134197 C DE 134197C
- Authority
- DE
- Germany
- Prior art keywords
- zinc
- gelatose
- solution
- compounds
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- HCHKCACWOHOZIP-UHFFFAOYSA-N zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 10
- 229910052725 zinc Inorganic materials 0.000 claims description 10
- 239000011701 zinc Substances 0.000 claims description 10
- 150000001875 compounds Chemical class 0.000 claims description 8
- 239000003292 glue Substances 0.000 claims description 4
- 150000003751 zinc Chemical class 0.000 claims description 4
- 102100001249 ALB Human genes 0.000 claims description 2
- 101710027066 ALB Proteins 0.000 claims description 2
- 229940050528 albumin Drugs 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 229940091251 Zinc Supplements Drugs 0.000 description 9
- 239000000243 solution Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 5
- 229910052751 metal Inorganic materials 0.000 description 5
- 239000002184 metal Substances 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 230000001225 therapeutic Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- NDVLTYZPCACLMA-UHFFFAOYSA-N Silver oxide Chemical compound [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 description 2
- 229940027985 antiseptics and disinfectants Silver compounds Drugs 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 150000003379 silver compounds Chemical class 0.000 description 2
- 229940100890 silver compounds Drugs 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 102000006395 Globulins Human genes 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- 210000004400 Mucous Membrane Anatomy 0.000 description 1
- DJWUNCQRNNEAKC-UHFFFAOYSA-L Zinc acetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O DJWUNCQRNNEAKC-UHFFFAOYSA-L 0.000 description 1
- JIAARYAFYJHUJI-UHFFFAOYSA-L Zinc chloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L Zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000003212 astringent agent Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000000622 irritating Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000000717 retained Effects 0.000 description 1
- 229910001923 silver oxide Inorganic materials 0.000 description 1
- 239000002602 strong irritant Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000004246 zinc acetate Substances 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
KAISERLICHESIMPERIAL
PATENTAMT.PATENT OFFICE.
Gemäfs Patentschrift 105866 erhält man eine wichtige Gruppe von löslichen Silberverbindungen durch Wechselwirkung von Silbersalzen oder Silberoxyd mit Albumosen. Während zur Darstellung dieser wichtigen Silberverbindungen die verschiedensten Albumosen, wie Protalbumosen, Deuteroalbumoseri, Heteroalbumosen, die Leimalbumosen (die sogen. GeIatosen) etc. verwendbar sind, war es bisher nicht möglich, durch Wechselwirkung von Zinksalzen und Eiweifsalbumosen, z. B. Protalbumose, Verbindungen zu erhalten, die auch nur einen einigermafsen genügenden Procentsatz an Metall enthielten, um noch für therapeutische Zwecke in Betracht kommen zu können.According to patent specification 105866 one obtains a important group of soluble silver compounds due to the interaction of silver salts or silver oxide with albumoses. While to represent these important silver compounds the most varied of albumoses, such as protalbumoses, deuteroalbumoseri, heteroalbumoses, the glue albums (the so-called geiatoses) etc. can be used, it was up to now not possible due to the interaction of zinc salts and albuminous albumin, e.g. B. Protalbumosis, To get connections that are even a reasonably sufficient percentage contained in metal in order to be able to be considered for therapeutic purposes.
Es wurde nun die Beobachtung gemacht, dafs es mit Hülfe einer bestimmten Albumoseart, nämlich der sogen. Gelatosen, d. h. der Leimalbumosen, möglich ist, zu leicht löslichen Albumoseverbindungen des Zinks zu gelangen, die einen relativ hohen Metallgehalt aufweisen und von grofsem therapeutischen Werth sind. Bekanntlich spielen die Zinksalze als adstringirende Mittel eine grofse Rolle in der Therapie. Sie weisen nur den erheblichen Uebelstand auf, dafs sie neben der adstringirenden Wirkung eine starke Reizwirkung auf die Schleimhäute ausüben.It has now been observed that with the help of a certain kind of albumose, namely the so-called. Gelatoses, d. H. of glue albums, it is possible to easily dissolve To get albumose compounds of zinc, which have a relatively high metal content and are of great therapeutic value. As is well known, the zinc salts play as astringents Means a great role in therapy. They only show the considerable evil on that, in addition to the astringent effect, it has a strong irritant effect on the mucous membranes exercise.
In den neuen Zinkgelatoseverbindungen ist nun die Eigenschaft der bisher gebräuchlichen Zinksalze, Reizwirkungen auszuüben, ganz bedeutend herabgesetzt, während andererseits die adstringirende Wirkung des in ihnen enthaltenen Metalles vollkommen erhalten geblieben ist.In the new zinc gelatose compounds, the property is now the one previously used Zinc salts, exerting irritating effects, are considerably reduced, while on the other hand the the astringent effect of the metal contained in them has been completely retained.
Die in der Patentschrift 101683 beschriebenen Verbindungen des Zinks mit Pflanzeneiweifsstoffen (Globulinen), bei deren Darstellung die Säuren der Metallsalze zwecks Erzielung löslicher Producte erst noch durch genau titrirte Mengen Alkali neutralisirt werden müssen, zeigen im Gegensatz zu den Metallgelatoseverbindungen die adstringirende Wirkung des Zinks nicht mehr, sie haben deshalb eine therapeutische Verwendung nicht finden können.Those described in patent 101683 Compounds of zinc with vegetable proteins (globulins), in the representation of which the Acids of metal salts, for the purpose of obtaining soluble products, must first be titrated precisely Quantities of alkali which have to be neutralized show in contrast to the metal gelatose compounds the astringent effect of zinc no longer has a therapeutic effect Cannot find use.
Die Darstellung der neuen Producte erfolgt in der Weise, dafs man anorganische oder organische Salze des Zinks auf die Leimalbumosen in Gegenwart eines geeigneten Lösungsmittels einwirken läfst.The new products are presented in such a way that they are inorganic or organic salts of zinc on glue albums in the presence of a suitable solvent has an effect.
Eine Lösung von 100 g Gelatose (hergestellt in üblicher Weise durch Erhitzen von Glutin mit gespanntem Wasserdampf) in 150 g 3oprocentigen Alkohols wird mit einer Lösung von 20 g krystallisirtem Zinkchlorid in 20 g Wasser gemischt. Aus dieser Mischung wird die entstandene neue Verbindung durch weiteren Zusatz von starkem Alkohol (96 pCt.) gefällt. Die ausgefällte, getrocknete und gepulverte Zinkgelatoseverbindung ist ein weifses Pulver mit einem Zinkgehalt von ca. 6 pCt.A solution of 100 g gelatose (made in the usual way by heating glutin with pressurized steam) in 150 g of 3% alcohol is mixed with a solution of 20 g of crystallized zinc chloride mixed in 20 g of water. This mixture becomes the resulting one new compound precipitated by further addition of strong alcohol (96 pCt.). The precipitated, dried and powdered Zinc gelatose compound is a white powder with a zinc content of approx. 6 pCt.
Eine Lösung von 100 g Gelatose in 100 g Wasser wird mit einer kalt gesättigten wässerigen Lösung von 40 g krystallisirtem Zinksulfat versetzt. Die klare Lösung wird darauf, wie in Beispiel 1 beschrieben, mit Alkohol gefällt, der Niederschlag getrocknet und gepulvert.A solution of 100 g gelatose in 100 g Water is mixed with a cold, saturated aqueous solution of 40 g of crystallized zinc sulfate offset. The clear solution is then, as described in Example 1, precipitated with alcohol, the precipitate dried and powdered.
Eine Lösung von 100 g Gelatose in 150 g 3oprocentiger Essigsäure wird mit einer Lösung von 30 g krystallisirtem Zinkacetat in 60 g Wasser gemischt und die Lösung mit Alkohol gefällt, der entstandene Niederschlag gepulvert und getrocknet. Der Zinkgehalt der so erhaltenen Zinkgelatoseverbindung beträgt circa 6 pCt.A solution of 100 g gelatose in 150 g 30% acetic acid is mixed with a solution of 30 g of crystallized zinc acetate in 60 g Water mixed and the solution precipitated with alcohol, the resulting precipitate powdered and dried. The zinc content of the zinc gelatose compound thus obtained is approx 6 pct.
Claims (1)
Verfahren zur Darstellung von Zinkgelatoseverbindungen, darin bestehend, dafs man Zinksalze in Gegenwart eines Lösungsmittels auf Leimalbumosen (Gelatosen) einwirken läfst.Patent claim:
Process for the preparation of zinc gelatose compounds, consisting in allowing zinc salts to act on glue albumin (gelatoses) in the presence of a solvent.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT12018D AT12018B (en) | 1901-04-16 | 1902-07-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE134197C true DE134197C (en) |
Family
ID=402340
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE1901134197D Expired - Lifetime DE134197C (en) | 1901-04-16 | 1901-04-16 |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE134197C (en) |
-
1901
- 1901-04-16 DE DE1901134197D patent/DE134197C/de not_active Expired - Lifetime
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