DE339537C - Process for the production of water-soluble glycerol phosphoric acid iron protein preparations - Google Patents
Process for the production of water-soluble glycerol phosphoric acid iron protein preparationsInfo
- Publication number
- DE339537C DE339537C DE1919339537D DE339537DD DE339537C DE 339537 C DE339537 C DE 339537C DE 1919339537 D DE1919339537 D DE 1919339537D DE 339537D D DE339537D D DE 339537DD DE 339537 C DE339537 C DE 339537C
- Authority
- DE
- Germany
- Prior art keywords
- iron
- phosphoric acid
- water
- production
- glycerol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
Description
Verfahren zur Herstellung von wasserlöslichen glyzerinphosphorsauren Eiseneiweißpräparaten. Um den Eisenpräparaten einen gewissen Nährwert zu verleihen und um sie bekömmlicher zu machen, wird Eisen an Eiweiß gebunden.Process for the production of water-soluble glycerol phosphoric acids Iron protein supplements. To add some nutritional value to the iron supplements and to make it more digestible, iron is bound to protein.
Bei den Versuchen, glyzerinphosphorsaures Eisen mit Eiweißlösung zu kombinieren, stellte sich heraus, daß eine unlösliche Eisenverbindung entsteht.When trying to add glycerol phosphoric acid with protein solution combine, it turned out that an insoluble iron compound is formed.
Es wurde nun gefunden, daß der aus der Eiweißlösung abgeschiedene Niederschlag nach Zusatz von Natrium glyzerinophosphorikum in Lösung ging und dauernd gelöst blieb.It has now been found that the deposited from the protein solution Precipitation after the addition of sodium glycerinophosphorus went into solution and continued remained resolved.
Der zur Konservierung dienende Alkohol verursachte keine Eiweißfällung mehr. Weiter wurde beobachtet, daß kleine Mengen von Salzsäure keine Ausscheidung der Eiweißverbindung hervorriefen.The alcohol used for preservation did not cause any protein precipitation more. It has also been observed that small amounts of hydrochloric acid do not excrete the protein compound.
Aus der Patentschrift =9512o ist es bekannt, Eisenalbuminat durch Zusatz von Eisenzucker und glyzerinphosphorsaurem Natrium löslich zu machen. Das vorliegende Verfahren betrifft jedoch nicht dieses gewöhnliche Eisenalbuminat, sondern eine glyzerinphosphorsaure Eisenverbindung des Eiweißes, die vollständig unlöslich ist und durch Natrium glyzerinophosphorikum in lösliche Form übergeführt werden soll. Eisenzucker wird bei vorliegendem Verfahren nicht angewendet. Natrium glyzerinophosphorikum wird im Überschuß zugesetzt, wodurch erreicht wird, daß die neue Eisenverbindung durch die Salzsäure des Magens nicht zersetzt und die Assimilation des unzersetzten glyzerinphosphorsaurenEisens ermöglicht wird. Im Gegensatz hierzu wird in der Patentschrift 19512o Wert darauf gelegt, daß nur kleine Mengen Natrium glyzerinophosphorikum das Eisenalbuminat in Lösung bringen.From the patent specification = 9512o it is known to use iron albuminate To make the addition of iron sugar and sodium glycerol phosphate soluble. That however, the present method is not concerned with this common iron albuminate, but with a glycerophosphate iron compound of protein that is completely insoluble and are converted into soluble form by sodium glycerinophosphorus target. Iron sugar is not used in the present process. Sodium glycerinophosphoric is added in excess, whereby it is achieved that the new iron compound not decomposed by the hydrochloric acid of the stomach and the assimilation of the undecomposed glycerol phosphoric acid iron is made possible. In contrast, the patent 19512o attached importance to the fact that only small amounts of sodium glycerinophosphoric the Bring iron albuminate into solution.
Der Erfindungsgedanke liegt darin, ein lösliches und nicht leicht durch die Magensalzsäure- zersetzbares Präparat der Glyzerinphosphorsäure mit Eisei%herzustellen; dä gerade die glyzerinphosphorsauren Salze wegen ihrer unmittelbareri'Assimilierbarkeit_'wertvolle Arzneimittel bilden.The idea of the invention is to be a soluble and not easy to produce a decomposable preparation of glycerol phosphoric acid with iron egg% by means of gastric hydrochloric acid; The glycerol-phosphoric acid salts are especially valuable because of their direct assimilability Form Medicines.
Die Assimilierbarkeit des glyzerinphosphorsauren Eisens war bisher nicht zu erreichen, da es durch die Magensalzsäure vollständig in Eisenchlorid und Glyzerinphosphorsäure zersetzt wurde. . Auch für subkutane Injektion war das glyzerinphosphorsaure Eisen bisher nicht brauchbar, da es das Serumeiweiß fällt und hierdurch Embolien hervorruft.The assimilability of the glycerol phosphoric acid iron was previously not to be achieved as it is completely converted into ferric chloride and by the hydrochloric acid in the stomach Glycerol phosphoric acid has been decomposed. . Glycerinphosphoric acid was also used for subcutaneous injection Iron has not been usable up to now because it drops the serum protein and thus embolism evokes.
Durch das angegebene Verfahren ist erreicht worden, daß Natrium glyzerinophosphorikum die Zersetzbarkeit des glyzerinphosphorsauren Eisens durch die Magensalzsäure verhütet und ferner seine eiweißfällenden Eigenschaften beseitigt. Es handelt sich demnach nicht darum, ein gewöhnliches lösliches Eisenalbuminat, wie es in der angezogenen Patentschrift gekennzeichnet ist, herzustellen, sondern ein assimilierbares glyzerinphosphorsaures Eisenpräparat zu erzeugen.By the specified method it has been achieved that sodium glycerinophosphoric prevents the decomposition of the glycerol-phosphoric acid iron by the gastric hydrochloric acid and also eliminates its protein precipitating properties. It is accordingly not a matter of an ordinary soluble iron albuminate, as it is in the attracted Patent is characterized to produce, but an assimilable glycerol phosphoric acid To produce iron supplement.
Die österreichische Patentschrift 66592 betrifft Verbindungen von Kasein mit glyzerinphosphorsaurem Eisen. Es-wurde festgestellt, daß Milchalbumin ebenso von glyzerinphosphorsaurem Eisen gefällt wird wie Hühnereiweiß und Pepton, daß dagegen Kasein nicht gefällt wird.Austrian patent 66592 relates to compounds of Casein with glycerol-phosphoric iron. It was determined, that Lactic albumin is also precipitated from glycerol-phosphoric iron, as is chicken protein and peptone, on the other hand, that casein is not precipitated.
Die 'Verbindung von> Zasein mit glyzerinphosphor,saurem Eisen .Mrd durch Spuren von SaIzsäure-°fersetzt. " "' Beispiel. Eine Lösung von z5 g Eiweiß oder Pepton in 55o g Wasser versetzt man mit r5o g einer io prozentigen Lösung von glyzerinphosphor, saurem Eisen und 6o g einer 5oprozentigen Lösung von glyzerinphosphorsaurem Natrium. Sodann fügt man i5o g Zuckersirup und ioo g Spiritus hinzu.The connection of zasein with glycerine phosphorus, acid iron replaced by traces of hydrochloric acid. " "' Example. A solution of about 5 g of protein or peptone in 55o g of water are mixed with 50 g of an 10 percent solution of glycerine phosphorus, acid iron and 60 g of a 5% solution of glycerine phosphoric acid Sodium. Then add 150 g of sugar syrup and 100 g of alcohol.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE339537T | 1919-08-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE339537C true DE339537C (en) | 1921-07-27 |
Family
ID=6223736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1919339537D Expired DE339537C (en) | 1919-08-02 | 1919-08-02 | Process for the production of water-soluble glycerol phosphoric acid iron protein preparations |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE339537C (en) |
-
1919
- 1919-08-02 DE DE1919339537D patent/DE339537C/en not_active Expired
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