ES8405787A1 - Un procedimiento para la preparacion de nuevos derivados de 4-amino-6,7-dimetoxi-2-piperazinoquinazolina. - Google Patents
Un procedimiento para la preparacion de nuevos derivados de 4-amino-6,7-dimetoxi-2-piperazinoquinazolina.Info
- Publication number
- ES8405787A1 ES8405787A1 ES508383A ES508383A ES8405787A1 ES 8405787 A1 ES8405787 A1 ES 8405787A1 ES 508383 A ES508383 A ES 508383A ES 508383 A ES508383 A ES 508383A ES 8405787 A1 ES8405787 A1 ES 8405787A1
- Authority
- ES
- Spain
- Prior art keywords
- aralkoxy
- pyridazinyl
- pyrazinyl
- pyrimidinyl
- alkylthio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/22—Nitrogen and oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/42—One nitrogen atom
- C07D251/44—One nitrogen atom with halogen atoms attached to the two other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/42—One nitrogen atom
- C07D251/46—One nitrogen atom with oxygen or sulfur atoms attached to the two other ring carbon atoms
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE 4-AMINO-6,7-DIMETOXI-2-PIPERAZINOQUINAZOLINA , DE FORMULA GENERAL (I), EN LA QUE HET ES UN GRUPO PIRIMIDINILO, PIRAZINILO, PIRIDAZINILO O TRIAZINILO, Y SUS SALES DE ADICION DE ACIDOS FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN SUSTITUIR EL GRUPO AMINO DE UN DERIVADO DE PIPERAZINA DE FDRMULA GENERAL (II), MEDIANTE REACCION CON UN COMPUESTO DE FORMULA: L-W, PARA OBTENER EL COMPUESTO BUSCADO DE FORMULA (III), EN LAS QUE L ES UN GRUPO FACILMENTE SALIENTE Y W Y W SON RADICALES.DE APLICACION COMO REGULADORES DEL SISTEMA CARDIOVASCULAR,Y EN ESPECIAL SE APLICAN EN EL TRATAMIENTO DE LA HIPERTENSION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8041411 | 1980-12-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8405787A1 true ES8405787A1 (es) | 1984-06-16 |
ES508383A0 ES508383A0 (es) | 1984-06-16 |
Family
ID=10518236
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES508383A Granted ES508383A0 (es) | 1980-12-29 | 1981-12-28 | Un procedimiento para la preparacion de nuevos derivados de 4-amino-6,7-dimetoxi-2-piperazinoquinazolina. |
Country Status (23)
Country | Link |
---|---|
US (3) | US4435401A (es) |
EP (1) | EP0055583B1 (es) |
JP (1) | JPS57181068A (es) |
KR (1) | KR830007635A (es) |
AR (1) | AR228631A1 (es) |
AT (1) | ATE15191T1 (es) |
AU (1) | AU529367B2 (es) |
CA (1) | CA1165318A (es) |
CS (1) | CS236667B2 (es) |
DD (1) | DD201901A5 (es) |
DE (1) | DE3172089D1 (es) |
DK (1) | DK152430C (es) |
ES (1) | ES508383A0 (es) |
FI (1) | FI70411C (es) |
GR (1) | GR76980B (es) |
IE (1) | IE52232B1 (es) |
IL (1) | IL64665A (es) |
NO (1) | NO814454L (es) |
PH (1) | PH17079A (es) |
PL (2) | PL136217B1 (es) |
PT (1) | PT74205B (es) |
YU (1) | YU312781A (es) |
ZA (1) | ZA818932B (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI70411C (fi) * | 1980-12-29 | 1986-09-19 | Pfizer | Foerfarande foer framstaellning av nya antihypertensiva 4-amino-6,7-dimetoxi-2-piperazinokinazolin derivat |
DE3114088A1 (de) * | 1981-04-08 | 1982-10-28 | Bayer Ag, 5090 Leverkusen | Wasserloesliche triazinverbindungen, ihre herstellung und ihre verwendung |
FR2521560A1 (fr) * | 1982-02-17 | 1983-08-19 | Adir | Nouveaux derives de piperazine et d'homopiperazine, leurs procedes de preparation et les compositions pharmaceutiques les renfermant |
CH651027A5 (de) * | 1982-11-12 | 1985-08-30 | Sandoz Ag | Heterocyclische verbindungen, ihre herstellung und verwendung. |
US5001125A (en) | 1984-03-26 | 1991-03-19 | Janssen Pharmaceutica N.V. | Anti-virally active pyridazinamines |
JPS61140568A (ja) * | 1984-12-14 | 1986-06-27 | Mitsui Petrochem Ind Ltd | キナゾリン誘導体及びそれを有効成分とする血圧降下剤 |
JPS6267077A (ja) * | 1985-09-18 | 1987-03-26 | Mitsui Petrochem Ind Ltd | キナゾリン誘導体及び医薬 |
US4734418A (en) * | 1984-12-14 | 1988-03-29 | Mitsui Petrochemical Industries, Ltd. | Quinazoline compounds and antihypertensives |
AT384218B (de) * | 1985-12-04 | 1987-10-12 | Gerot Pharmazeutika | Verfahren zur herstellung von neuen chinazolin-derivaten |
US5072564A (en) * | 1988-10-11 | 1991-12-17 | Campana Technology, Inc. | Decorative panel |
CA2065443A1 (en) * | 1990-07-03 | 1992-01-04 | Akira Mizuchi | Pyrimidine compound and pharmaceutically acceptable salts thereof |
IL108630A0 (en) * | 1993-02-18 | 1994-05-30 | Fmc Corp | Insecticidal substituted 2,4-diaminoquinazolines |
IT1286302B1 (it) * | 1996-04-10 | 1998-07-08 | Rotta Research Lab | Chinazoline-4-amino-2-(piperidino-1-il-4-sostituite) ad attivita' anti-ipertensiva, procedimento per la loro preparazione e loro uso |
DE69842058D1 (de) * | 1997-10-27 | 2011-01-27 | Neurosearch As | Heteroaryl Diazacycloalkane als cholinergische Ligande für Nikotin-Acetylcholin-Rezeptoren |
US6150362A (en) * | 1997-12-12 | 2000-11-21 | Henkin; Jack | Triazine angiogenesis inhibitors |
US6825198B2 (en) * | 2001-06-21 | 2004-11-30 | Pfizer Inc | 5-HT receptor ligands and uses thereof |
US20050119251A1 (en) * | 2001-12-21 | 2005-06-02 | Jian-Min Fu | Nicotinamide derivatives and their use as therapeutic agents |
MY145822A (en) * | 2004-08-13 | 2012-04-30 | Neurogen Corp | Substituted biaryl piperazinyl-pyridine analogues |
AR051090A1 (es) | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
CA2580844A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-coa desaturase |
JP4958785B2 (ja) | 2004-09-20 | 2012-06-20 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 複素環誘導体およびステアロイル−CoAデサチュラーゼインヒビターとしてのそれらの使用 |
EP1799664A1 (en) | 2004-09-20 | 2007-06-27 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
JP4958786B2 (ja) | 2004-09-20 | 2012-06-20 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 複素環誘導体および治療薬としてのそれらの使用 |
CN101083986A (zh) * | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 双环杂环衍生物及其作为硬脂酰CoA去饱和酶(SCD)抑制剂的用途 |
US7829712B2 (en) | 2004-09-20 | 2010-11-09 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase |
EP2316457A1 (en) * | 2004-09-20 | 2011-05-04 | Xenon Pharmaceuticals Inc. | Pyridine derivatives for inhibiting human stearoyl-coa-desaturase |
AR051026A1 (es) | 2004-09-20 | 2006-12-13 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
US8541457B2 (en) | 2005-06-03 | 2013-09-24 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-CoA desaturase inhibitors |
CA2681162C (en) | 2007-03-15 | 2015-11-24 | Novartis Ag | Benzyl and pyridine derivatives as modulators of hedgehog pathway |
US20100041663A1 (en) * | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
GB201008210D0 (en) * | 2010-05-17 | 2010-06-30 | Senexis Ltd | Compounds |
GB201008209D0 (en) * | 2010-05-17 | 2010-06-30 | Senexis Ltd | Compounds |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3496179A (en) * | 1967-10-11 | 1970-02-17 | Pfizer & Co C | 2-amino-3,4-dihydroquinazolines |
US3517005A (en) | 1967-10-26 | 1970-06-23 | Pfizer & Co C | Certain 2- and 4-substituted quinazolines |
US3511836A (en) | 1967-12-13 | 1970-05-12 | Pfizer & Co C | 2,4,6,7-tetra substituted quinazolines |
US3669968A (en) | 1970-05-21 | 1972-06-13 | Pfizer | Trialkoxy quinazolines |
US3900476A (en) | 1973-05-17 | 1975-08-19 | Upjohn Co | 2(2'-pyrimidylamino)quinazolines and their preparation |
US3935213A (en) * | 1973-12-05 | 1976-01-27 | Pfizer Inc. | Process for hypotensive 4-amino-2-(piperazin-1-yl) quinazoline derivatives |
US4062844A (en) * | 1976-09-20 | 1977-12-13 | Pfizer Inc. | Process for preparing hypotensive 2-(4-aroylpiperazin-1-yl)-amino-6,7-dimethoxyquinazolines |
US4171363A (en) | 1977-02-22 | 1979-10-16 | Bristol-Myers Company | 1,2,3-Thiadiazole process |
US4101548A (en) * | 1977-02-22 | 1978-07-18 | Bristol-Myers Company | 1,2,3-Thiadiazole amides |
US4188390A (en) | 1977-11-05 | 1980-02-12 | Pfizer Inc. | Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines |
US4161595A (en) | 1978-10-02 | 1979-07-17 | Bristol-Myers Company | Levulinic acid salt |
FI67699C (fi) * | 1979-01-31 | 1985-05-10 | Orion Yhtymae Oy | Foerfarande foer framstaellning av 6,7-dimetoxi-4-amino-2-(4-(2-furoyl)-1-piperazinyl)kinazolinhydroklorid med blodtryckssaenkande verkan |
US4287341A (en) | 1979-11-01 | 1981-09-01 | Pfizer Inc. | Alkoxy-substituted-6-chloro-quinazoline-2,4-diones |
US4351832A (en) | 1980-04-18 | 1982-09-28 | American Home Products Corporation | 2-(Piperazinyl)-4-pyrimidinamines |
FI70411C (fi) * | 1980-12-29 | 1986-09-19 | Pfizer | Foerfarande foer framstaellning av nya antihypertensiva 4-amino-6,7-dimetoxi-2-piperazinokinazolin derivat |
-
1981
- 1981-12-17 FI FI814055A patent/FI70411C/fi not_active IP Right Cessation
- 1981-12-22 AT AT81306025T patent/ATE15191T1/de active
- 1981-12-22 DE DE8181306025T patent/DE3172089D1/de not_active Expired
- 1981-12-22 DK DK569781A patent/DK152430C/da not_active IP Right Cessation
- 1981-12-22 EP EP81306025A patent/EP0055583B1/en not_active Expired
- 1981-12-23 AU AU78846/81A patent/AU529367B2/en not_active Ceased
- 1981-12-23 ZA ZA@@@@00818932A patent/ZA818932B/xx unknown
- 1981-12-23 IE IE3053/81A patent/IE52232B1/en unknown
- 1981-12-23 CA CA000393109A patent/CA1165318A/en not_active Expired
- 1981-12-23 US US06/333,672 patent/US4435401A/en not_active Expired - Lifetime
- 1981-12-28 JP JP56216057A patent/JPS57181068A/ja active Granted
- 1981-12-28 IL IL64665A patent/IL64665A/xx unknown
- 1981-12-28 AR AR287957A patent/AR228631A1/es active
- 1981-12-28 DD DD81236333A patent/DD201901A5/de unknown
- 1981-12-28 PH PH26680A patent/PH17079A/en unknown
- 1981-12-28 GR GR66910A patent/GR76980B/el unknown
- 1981-12-28 NO NO814454A patent/NO814454L/no unknown
- 1981-12-28 ES ES508383A patent/ES508383A0/es active Granted
- 1981-12-28 PT PT74205A patent/PT74205B/pt unknown
- 1981-12-28 KR KR1019810005269A patent/KR830007635A/ko unknown
- 1981-12-29 CS CS819946A patent/CS236667B2/cs unknown
- 1981-12-29 YU YU03127/81A patent/YU312781A/xx unknown
- 1981-12-30 PL PL1981243280A patent/PL136217B1/pl unknown
- 1981-12-30 PL PL1981234523A patent/PL136268B1/pl unknown
-
1983
- 1983-08-24 US US06/526,005 patent/US4483859A/en not_active Expired - Lifetime
- 1983-08-24 US US06/525,964 patent/US4483857A/en not_active Expired - Lifetime
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