ES8401096A1 - Procedimiento para preparacion de 11 -cloro-esteroides. - Google Patents

Procedimiento para preparacion de 11 -cloro-esteroides.

Info

Publication number
ES8401096A1
ES8401096A1 ES520207A ES520207A ES8401096A1 ES 8401096 A1 ES8401096 A1 ES 8401096A1 ES 520207 A ES520207 A ES 520207A ES 520207 A ES520207 A ES 520207A ES 8401096 A1 ES8401096 A1 ES 8401096A1
Authority
ES
Spain
Prior art keywords
beta
general formula
group
chlorosteroids
see diagramm
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES520207A
Other languages
English (en)
Other versions
ES520207A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of ES8401096A1 publication Critical patent/ES8401096A1/es
Publication of ES520207A0 publication Critical patent/ES520207A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE 11B-CLORO-ESTEROIDES.CONSISTE EN HACER REACCIONAR UN 11B-CLORO-17-OXO-ESTEROIDE DE FORMULA (II) CON UN COMPUESTO CLOROETILINICO ORGANOMETALICO PARA FORMAR 11B-CLORO-ESTEROIDES DE FORMULA (I). SE HIDROLIZA UN GRUPO PROTECTOR DE 3-OXO INTRODUCIDO PRIMARIAMENTE Y SE ESTERIFICA EL GRUPO 17-HIDROXI ANTES O DESPUES DE LA SEPARACION DEL GRUPO PROTECTOR. DONDE R SIGNIFICA UN ATOMO DE H O UN GRUPO ACILO, Y UN GRUPO OXO LIBRE O UN GRUPO PROTECTOR DE OXO HIDROLIZABLE CON UN ACIDO, K SIGNIFICA DOBLE ENLACE EN POSICION 4,5; 5,6; O 5,10 O DOS DOBLESENLACES QUE PARTEN DE LAS POSICIONES 3 Y 5.TIENE APLICACIONES FARMACOLOGICAS POR SUS EFECTOS GESTAGENOS.
ES520207A 1982-04-16 1983-03-01 Procedimiento para preparacion de 11 -cloro-esteroides. Granted ES520207A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823214689 DE3214689A1 (de) 1982-04-16 1982-04-16 11ss-chlor-steroide, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate

Publications (2)

Publication Number Publication Date
ES8401096A1 true ES8401096A1 (es) 1983-12-01
ES520207A0 ES520207A0 (es) 1983-12-01

Family

ID=6161447

Family Applications (1)

Application Number Title Priority Date Filing Date
ES520207A Granted ES520207A0 (es) 1982-04-16 1983-03-01 Procedimiento para preparacion de 11 -cloro-esteroides.

Country Status (12)

Country Link
EP (1) EP0092173B1 (es)
JP (1) JPS58188899A (es)
AT (1) ATE18407T1 (es)
AU (1) AU555284B2 (es)
CA (1) CA1242697A (es)
DD (1) DD209635A5 (es)
DE (2) DE3214689A1 (es)
DK (1) DK92283A (es)
ES (1) ES520207A0 (es)
GR (1) GR78212B (es)
HU (1) HU186687B (es)
ZA (1) ZA832672B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4232521A1 (de) * 1992-09-22 1994-03-24 Schering Ag Gestagen wirksame 4,5;11,12-Estradiene, Verfahren zu ihrer Herstellung, diese Estradiene enthaltende Arzneimittel sowie deren Verwendung zur Herstellung von Arzneimitteln

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE651797A (es) * 1962-10-17
US3665021A (en) * 1966-07-29 1972-05-23 Glaxo Lab Ltd 9alpha-unsubstituted-11beta-chloro-l9 nos-steroids
NL7209299A (en) * 1972-07-01 1974-01-03 Delta-4-3-oxo-11-beta-halo steroids - with hormonal activity

Also Published As

Publication number Publication date
DK92283D0 (da) 1983-02-25
ZA832672B (en) 1983-12-28
EP0092173A1 (de) 1983-10-26
DE3214689A1 (de) 1983-10-27
ATE18407T1 (de) 1986-03-15
GR78212B (es) 1984-09-26
HU186687B (en) 1985-09-30
AU555284B2 (en) 1986-09-18
ES520207A0 (es) 1983-12-01
DE3362380D1 (en) 1986-04-10
AU1248783A (en) 1983-10-20
DD209635A5 (de) 1984-05-16
DK92283A (da) 1983-10-17
JPS58188899A (ja) 1983-11-04
CA1242697A (en) 1988-10-04
EP0092173B1 (de) 1986-03-05

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