ZA832672B - Gestagenically active 11 -chloro-steroids and their manufacture and use - Google Patents

Gestagenically active 11 -chloro-steroids and their manufacture and use

Info

Publication number
ZA832672B
ZA832672B ZA832672A ZA832672A ZA832672B ZA 832672 B ZA832672 B ZA 832672B ZA 832672 A ZA832672 A ZA 832672A ZA 832672 A ZA832672 A ZA 832672A ZA 832672 B ZA832672 B ZA 832672B
Authority
ZA
South Africa
Prior art keywords
general formula
group
see diagramm
beta
hydrogen
Prior art date
Application number
ZA832672A
Inventor
Helmut Hofmeister
Karl Petzoldt
Klaus Annen
Henry Laurent
Rudolf Wiechert
Nishino Yukeshige
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of ZA832672B publication Critical patent/ZA832672B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

(for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE) 1. 11 beta-chlorosteroids of general formula I see diagramm : EP0092173,P6,F1 wherein R is hydrogen or an acyl group of an organic carboxylic acid of up to 15 carbon atoms. (for the Contracting : AT) Process for the preparation of 11 beta-chlorosteroids of general formula I see diagramm : EP0092173,P7,F1 wherein R is hydrogen or an acyl group of an organic carboxylic acid of up 15 carbon atoms characterized in that a 11 beta-chloro-17-oxosteroid of the general formula II see diagramm : EP0092173,P7,F2 wherein, Y is a free oxo group of a hydrolyzable protected oxo group and see diagramm : EP0092173,P7,F3 is a double bond in the 4,5-, 5,6- or 5,10-positions or two double bonds in the 3- and 5-positions, is converted, in a known manner, with an organometallic chloroethynyl compound to a compound of general formula I in which R is hydrogen, a primary introduced 3-oxo protecting group is hydrolyzed and depending on the finally desired meaning of R, the 17-hydroxy group is optionally esterified, before or after removal of the protecting group.
ZA832672A 1982-04-16 1983-04-15 Gestagenically active 11 -chloro-steroids and their manufacture and use ZA832672B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823214689 DE3214689A1 (en) 1982-04-16 1982-04-16 11SS CHLORINE STEROIDS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM

Publications (1)

Publication Number Publication Date
ZA832672B true ZA832672B (en) 1983-12-28

Family

ID=6161447

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA832672A ZA832672B (en) 1982-04-16 1983-04-15 Gestagenically active 11 -chloro-steroids and their manufacture and use

Country Status (12)

Country Link
EP (1) EP0092173B1 (en)
JP (1) JPS58188899A (en)
AT (1) ATE18407T1 (en)
AU (1) AU555284B2 (en)
CA (1) CA1242697A (en)
DD (1) DD209635A5 (en)
DE (2) DE3214689A1 (en)
DK (1) DK92283A (en)
ES (1) ES8401096A1 (en)
GR (1) GR78212B (en)
HU (1) HU186687B (en)
ZA (1) ZA832672B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4232521A1 (en) * 1992-09-22 1994-03-24 Schering Ag Progestagenic 4,5; 11,12-estradienes, processes for their preparation, medicaments containing these estradienes and their use for the production of medicaments

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE651797A (en) * 1962-10-17
US3665021A (en) * 1966-07-29 1972-05-23 Glaxo Lab Ltd 9alpha-unsubstituted-11beta-chloro-l9 nos-steroids
NL7209299A (en) * 1972-07-01 1974-01-03 Delta-4-3-oxo-11-beta-halo steroids - with hormonal activity

Also Published As

Publication number Publication date
GR78212B (en) 1984-09-26
DD209635A5 (en) 1984-05-16
ES520207A0 (en) 1983-12-01
DE3362380D1 (en) 1986-04-10
DK92283D0 (en) 1983-02-25
DK92283A (en) 1983-10-17
EP0092173A1 (en) 1983-10-26
HU186687B (en) 1985-09-30
AU555284B2 (en) 1986-09-18
ES8401096A1 (en) 1983-12-01
ATE18407T1 (en) 1986-03-15
EP0092173B1 (en) 1986-03-05
CA1242697A (en) 1988-10-04
JPS58188899A (en) 1983-11-04
DE3214689A1 (en) 1983-10-27
AU1248783A (en) 1983-10-20

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