DK92283A - 11BETA-CHLORSTEROIDS, PROCEDURES FOR THE PRODUCTION OF IT, AND PHARMACEUTICAL PREPARATIONS WITH CONTENTS - Google Patents

11BETA-CHLORSTEROIDS, PROCEDURES FOR THE PRODUCTION OF IT, AND PHARMACEUTICAL PREPARATIONS WITH CONTENTS Download PDF

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Publication number
DK92283A
DK92283A DK92283A DK92283A DK92283A DK 92283 A DK92283 A DK 92283A DK 92283 A DK92283 A DK 92283A DK 92283 A DK92283 A DK 92283A DK 92283 A DK92283 A DK 92283A
Authority
DK
Denmark
Prior art keywords
general formula
group
see diagramm
beta
hydrogen
Prior art date
Application number
DK92283A
Other languages
Danish (da)
Other versions
DK92283D0 (en
Inventor
Helmut Hofmeister
Karl Petzoldt
Klaus Annen
Henry Laurent
Rudolf Wiechert
Yukeshige Nishino
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of DK92283D0 publication Critical patent/DK92283D0/en
Publication of DK92283A publication Critical patent/DK92283A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

(for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE) 1. 11 beta-chlorosteroids of general formula I see diagramm : EP0092173,P6,F1 wherein R is hydrogen or an acyl group of an organic carboxylic acid of up to 15 carbon atoms. (for the Contracting : AT) Process for the preparation of 11 beta-chlorosteroids of general formula I see diagramm : EP0092173,P7,F1 wherein R is hydrogen or an acyl group of an organic carboxylic acid of up 15 carbon atoms characterized in that a 11 beta-chloro-17-oxosteroid of the general formula II see diagramm : EP0092173,P7,F2 wherein, Y is a free oxo group of a hydrolyzable protected oxo group and see diagramm : EP0092173,P7,F3 is a double bond in the 4,5-, 5,6- or 5,10-positions or two double bonds in the 3- and 5-positions, is converted, in a known manner, with an organometallic chloroethynyl compound to a compound of general formula I in which R is hydrogen, a primary introduced 3-oxo protecting group is hydrolyzed and depending on the finally desired meaning of R, the 17-hydroxy group is optionally esterified, before or after removal of the protecting group.
DK92283A 1982-04-16 1983-02-25 11BETA-CHLORSTEROIDS, PROCEDURES FOR THE PRODUCTION OF IT, AND PHARMACEUTICAL PREPARATIONS WITH CONTENTS DK92283A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823214689 DE3214689A1 (en) 1982-04-16 1982-04-16 11SS CHLORINE STEROIDS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM

Publications (2)

Publication Number Publication Date
DK92283D0 DK92283D0 (en) 1983-02-25
DK92283A true DK92283A (en) 1983-10-17

Family

ID=6161447

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92283A DK92283A (en) 1982-04-16 1983-02-25 11BETA-CHLORSTEROIDS, PROCEDURES FOR THE PRODUCTION OF IT, AND PHARMACEUTICAL PREPARATIONS WITH CONTENTS

Country Status (12)

Country Link
EP (1) EP0092173B1 (en)
JP (1) JPS58188899A (en)
AT (1) ATE18407T1 (en)
AU (1) AU555284B2 (en)
CA (1) CA1242697A (en)
DD (1) DD209635A5 (en)
DE (2) DE3214689A1 (en)
DK (1) DK92283A (en)
ES (1) ES520207A0 (en)
GR (1) GR78212B (en)
HU (1) HU186687B (en)
ZA (1) ZA832672B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4232521A1 (en) * 1992-09-22 1994-03-24 Schering Ag Progestagenic 4,5; 11,12-estradienes, processes for their preparation, medicaments containing these estradienes and their use for the production of medicaments

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE651797A (en) * 1962-10-17
US3665021A (en) * 1966-07-29 1972-05-23 Glaxo Lab Ltd 9alpha-unsubstituted-11beta-chloro-l9 nos-steroids
NL7209299A (en) * 1972-07-01 1974-01-03 Delta-4-3-oxo-11-beta-halo steroids - with hormonal activity

Also Published As

Publication number Publication date
DE3214689A1 (en) 1983-10-27
EP0092173B1 (en) 1986-03-05
DK92283D0 (en) 1983-02-25
DD209635A5 (en) 1984-05-16
CA1242697A (en) 1988-10-04
ZA832672B (en) 1983-12-28
EP0092173A1 (en) 1983-10-26
GR78212B (en) 1984-09-26
ES8401096A1 (en) 1983-12-01
DE3362380D1 (en) 1986-04-10
ES520207A0 (en) 1983-12-01
HU186687B (en) 1985-09-30
JPS58188899A (en) 1983-11-04
AU1248783A (en) 1983-10-20
ATE18407T1 (en) 1986-03-15
AU555284B2 (en) 1986-09-18

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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment