ES8301912A1 - "procedimiento para la preparacion de derivados de carbaciclina". - Google Patents
"procedimiento para la preparacion de derivados de carbaciclina".Info
- Publication number
- ES8301912A1 ES8301912A1 ES509265A ES509265A ES8301912A1 ES 8301912 A1 ES8301912 A1 ES 8301912A1 ES 509265 A ES509265 A ES 509265A ES 509265 A ES509265 A ES 509265A ES 8301912 A1 ES8301912 A1 ES 8301912A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- carbon atoms
- see diagramm
- alkyl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical class O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- -1 hydroxymethylene group Chemical group 0.000 abstract 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000003839 salts Chemical group 0.000 abstract 3
- 101100294106 Caenorhabditis elegans nhr-3 gene Proteins 0.000 abstract 2
- XZFRIPGNUQRGPI-WLPVIMDJSA-N Carbacyclin Chemical class C1\C(=C\CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 XZFRIPGNUQRGPI-WLPVIMDJSA-N 0.000 abstract 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052744 lithium Inorganic materials 0.000 abstract 1
- 125000004665 trialkylsilyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
- C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
- C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Pyrane Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE CARBACICLINA Y DE SUS SALES DE ADICION FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R ES HIDROXI LIBRE O MODIFICADO; Y R , R , A, W, D Y E PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), EN LA QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), CON DIALCOHILAMIDA DE LITIO DE FORMULA R R N<024>LI, EN LA QUE R Y R PUEDEN SER VARIOS RADICALES, PARA INTRODUCIR UN DOBLE ENLACE EN POSICION 2; SEGUIDA DEL TRATAMIENTO CON UN COMPUESTO FENILICO DE FORMULA (III), EN LA QUE R PUEDE SER VARIOS RADICALES; Y FINALMENTE OXIDACION CON PERYODATO EN UN MEDIO ACUOALCOHOLICO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS EFECTOS HIPOTENSORES Y BRONCODILATADORES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19813104044 DE3104044A1 (de) | 1981-02-02 | 1981-02-02 | Neue prostacyclin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES509265A0 ES509265A0 (es) | 1983-01-16 |
| ES8301912A1 true ES8301912A1 (es) | 1983-01-16 |
Family
ID=6124154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES509265A Expired ES8301912A1 (es) | 1981-02-02 | 1982-02-02 | "procedimiento para la preparacion de derivados de carbaciclina". |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0057660B1 (es) |
| JP (1) | JPS57176924A (es) |
| AT (1) | ATE15029T1 (es) |
| AU (1) | AU7995782A (es) |
| DD (1) | DD201884A5 (es) |
| DE (2) | DE3104044A1 (es) |
| DK (1) | DK43482A (es) |
| ES (1) | ES8301912A1 (es) |
| FI (1) | FI820327L (es) |
| GR (1) | GR74746B (es) |
| IE (1) | IE820228L (es) |
| IL (1) | IL64902A0 (es) |
| NO (1) | NO820298L (es) |
| ZA (1) | ZA82670B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3237200A1 (de) * | 1982-10-05 | 1984-04-05 | Schering AG, 1000 Berlin und 4709 Bergkamen | 5-fluorcarbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| DE3204443A1 (de) * | 1982-02-08 | 1983-08-18 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| DE3221193A1 (de) * | 1982-05-28 | 1983-12-01 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacyclinester, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| JPS59141536A (ja) * | 1983-02-01 | 1984-08-14 | Sumitomo Chem Co Ltd | 新規ビシクロオクタン誘導体 |
| JPS60181041A (ja) * | 1984-02-29 | 1985-09-14 | Sankyo Co Ltd | カルバサイクリン誘導体 |
| JPS60172941A (ja) * | 1984-02-16 | 1985-09-06 | Sankyo Co Ltd | カルバサイクリン類 |
| KR20020016938A (ko) | 1999-08-05 | 2002-03-06 | 야스이 쇼사꾸 | 함질소화합물을 유효성분으로 하는 신경장해개선제 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4705806A (en) * | 1978-02-13 | 1987-11-10 | Morton Jr Douglas R | Prostacyclin analogs |
| DE2845770A1 (de) * | 1978-10-19 | 1980-04-30 | Schering Ag | Neue prostacyclin-derivate und verfahren zu ihrer herstellung |
-
1981
- 1981-02-02 DE DE19813104044 patent/DE3104044A1/de not_active Withdrawn
-
1982
- 1982-01-29 AU AU79957/82A patent/AU7995782A/en not_active Abandoned
- 1982-01-31 IL IL64902A patent/IL64902A0/xx unknown
- 1982-02-01 EP EP82730008A patent/EP0057660B1/de not_active Expired
- 1982-02-01 NO NO820298A patent/NO820298L/no unknown
- 1982-02-01 DK DK43482A patent/DK43482A/da not_active Application Discontinuation
- 1982-02-01 DD DD82237116A patent/DD201884A5/de unknown
- 1982-02-01 AT AT82730008T patent/ATE15029T1/de not_active IP Right Cessation
- 1982-02-01 GR GR67166A patent/GR74746B/el unknown
- 1982-02-01 DE DE8282730008T patent/DE3265495D1/de not_active Expired
- 1982-02-02 IE IE820228A patent/IE820228L/xx unknown
- 1982-02-02 ZA ZA82670A patent/ZA82670B/xx unknown
- 1982-02-02 JP JP57014399A patent/JPS57176924A/ja active Granted
- 1982-02-02 ES ES509265A patent/ES8301912A1/es not_active Expired
- 1982-02-02 FI FI820327A patent/FI820327L/fi not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| FI820327L (fi) | 1982-08-03 |
| ZA82670B (en) | 1982-12-29 |
| EP0057660A2 (de) | 1982-08-11 |
| JPH0451537B2 (es) | 1992-08-19 |
| ATE15029T1 (de) | 1985-09-15 |
| DD201884A5 (de) | 1983-08-17 |
| EP0057660B1 (de) | 1985-08-21 |
| NO820298L (no) | 1982-08-03 |
| IL64902A0 (en) | 1982-03-31 |
| AU7995782A (en) | 1982-08-12 |
| GR74746B (es) | 1984-07-11 |
| JPS57176924A (en) | 1982-10-30 |
| ES509265A0 (es) | 1983-01-16 |
| DK43482A (da) | 1982-08-03 |
| EP0057660A3 (en) | 1982-09-01 |
| IE820228L (en) | 1982-08-02 |
| DE3104044A1 (de) | 1982-08-26 |
| DE3265495D1 (en) | 1985-09-26 |
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