ES8305352A1 - Procedimiento para la preparacion de nuevos compuestos de aorilimidazol-2-ona. - Google Patents
Procedimiento para la preparacion de nuevos compuestos de aorilimidazol-2-ona.Info
- Publication number
- ES8305352A1 ES8305352A1 ES510087A ES510087A ES8305352A1 ES 8305352 A1 ES8305352 A1 ES 8305352A1 ES 510087 A ES510087 A ES 510087A ES 510087 A ES510087 A ES 510087A ES 8305352 A1 ES8305352 A1 ES 8305352A1
- Authority
- ES
- Spain
- Prior art keywords
- aroylimidazolones
- novel
- aroylimidazole
- cardiotonics
- ones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000000496 cardiotonic agent Substances 0.000 abstract 1
- 230000003177 cardiotonic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Luminescent Compositions (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24088981A | 1981-03-05 | 1981-03-05 | |
| US06/314,312 US4405628A (en) | 1981-03-05 | 1981-10-23 | 4-Pyridylimidazolones and method of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES510087A0 ES510087A0 (es) | 1983-04-16 |
| ES8305352A1 true ES8305352A1 (es) | 1983-04-16 |
Family
ID=26933806
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES510087A Expired ES8305352A1 (es) | 1981-03-05 | 1982-03-03 | Procedimiento para la preparacion de nuevos compuestos de aorilimidazol-2-ona. |
| ES519254A Granted ES519254A0 (es) | 1981-03-05 | 1983-01-25 | Procedimiento para la preparacion de nuevos compuestos de aroilimidazol-2-ona. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES519254A Granted ES519254A0 (es) | 1981-03-05 | 1983-01-25 | Procedimiento para la preparacion de nuevos compuestos de aroilimidazol-2-ona. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4405628A (enExample) |
| EP (1) | EP0059948B1 (enExample) |
| KR (1) | KR890000765B1 (enExample) |
| AT (1) | ATE16489T1 (enExample) |
| AU (1) | AU557590B2 (enExample) |
| CA (1) | CA1190550A (enExample) |
| DE (1) | DE3267352D1 (enExample) |
| DK (1) | DK168627B1 (enExample) |
| ES (2) | ES8305352A1 (enExample) |
| GB (1) | GB2096600B (enExample) |
| GR (1) | GR76518B (enExample) |
| HK (1) | HK61686A (enExample) |
| IE (1) | IE52387B1 (enExample) |
| IL (1) | IL65137A (enExample) |
| MY (1) | MY8600700A (enExample) |
| NO (1) | NO157175C (enExample) |
| NZ (1) | NZ199885A (enExample) |
| PH (1) | PH18345A (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4367236A (en) * | 1981-11-04 | 1983-01-04 | Merrell Dow Pharmaceuticals Inc. | Method for the treatment of cardiac failure with alkanoylimidazol-2-one derivatives |
| US4552880A (en) * | 1983-02-15 | 1985-11-12 | Merrell Dow Pharmaceuticals Inc. | Aroylimidazolones |
| US4532250A (en) * | 1983-11-23 | 1985-07-30 | American Hospital Supply Corporation | 5-Heteroarylimidazol-2-ones having cardiotonic activity |
| US4556665A (en) * | 1984-07-09 | 1985-12-03 | Schering A.G. | Cardiotonic 1,3-dihydro-4-[[(imidazol-1-yl)aryl]carbonyl]imidazol-2-ones |
| US4803278A (en) * | 1984-07-30 | 1989-02-07 | Merrell Dow Pharmaceuticals, Inc. | Preparation of 1,3-dihydro-4-pyridoyl-2H-imidazol-2-ones |
| ZA855592B (en) * | 1984-07-30 | 1986-03-26 | Merrell Dow Pharma | The preparation of 1,3-dihydro-4-pyridoyl-2h-imidazol-2-ones |
| ZA881807B (en) * | 1987-03-20 | 1988-09-05 | Merrell Dow Pharmaceuticals Inc. | Method for reducing reperfusion injury with imidazol-2-thiones |
| US4999365A (en) * | 1987-03-20 | 1991-03-12 | Merrell Dow Pharmaceuticals Inc. | Method of reducing reperfusion injury with imidazol-2-thiones |
| ZA887662B (en) * | 1987-10-19 | 1989-06-28 | Merrell Dow Pharma | Method for reducing reperfusion injury with imidazol-2-thione-carboxamides |
| AU8212491A (en) * | 1990-06-29 | 1992-01-23 | Upjohn Company, The | Substituted 1-(alkoxyphenyl)piperazines with cns and antihypertensive activity |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| MX354786B (es) | 2007-06-04 | 2018-03-21 | Synergy Pharmaceuticals Inc | Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos. |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| ES2522968T3 (es) | 2008-06-04 | 2014-11-19 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| AU2009270833B2 (en) | 2008-07-16 | 2015-02-19 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| DK2681236T3 (en) | 2011-03-01 | 2018-04-16 | Synergy Pharmaceuticals Inc | PROCEDURE FOR MANUFACTURING GUANYLATE CYCLASE-C-AGONISTS |
| WO2014131024A2 (en) | 2013-02-25 | 2014-08-28 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| AU2014235215A1 (en) | 2013-03-15 | 2015-10-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
| BR112015030326A2 (pt) | 2013-06-05 | 2017-08-29 | Synergy Pharmaceuticals Inc | Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos |
| AU2014305843B2 (en) | 2013-08-09 | 2019-08-29 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| EP4706758A3 (en) | 2019-05-21 | 2026-05-06 | Ardelyx, Inc. | Methods for inhibiting phosphate transport |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2441933A (en) * | 1945-07-30 | 1948-05-18 | Hoffmann La Roche | Substituted imidazolones and process of making them |
| US3538104A (en) * | 1969-02-28 | 1970-11-03 | Geigy Chem Corp | Pyridyl-2-imidazolones |
| ZA803332B (en) * | 1979-06-18 | 1981-01-28 | Richardson Merrell Inc | Novel 4-aroylimidazol-2-ones |
| NZ193935A (en) * | 1979-06-18 | 1985-05-31 | Richardson Merrell Inc | 4-aroyl-imidazol-2-one derivatives;pharmaceutical compositions |
| PH18106A (en) * | 1981-02-18 | 1985-03-21 | Merrell Dow Pharma | Novel-4-aroylimidazol-2-ones |
-
1981
- 1981-10-23 US US06/314,312 patent/US4405628A/en not_active Expired - Lifetime
-
1982
- 1982-03-01 PH PH26929A patent/PH18345A/en unknown
- 1982-03-01 CA CA000397351A patent/CA1190550A/en not_active Expired
- 1982-03-01 IL IL65137A patent/IL65137A/xx not_active IP Right Cessation
- 1982-03-02 AU AU81037/82A patent/AU557590B2/en not_active Ceased
- 1982-03-02 GR GR67455A patent/GR76518B/el unknown
- 1982-03-02 NZ NZ199885A patent/NZ199885A/en unknown
- 1982-03-03 ES ES510087A patent/ES8305352A1/es not_active Expired
- 1982-03-04 GB GB8206412A patent/GB2096600B/en not_active Expired
- 1982-03-04 DE DE8282101706T patent/DE3267352D1/de not_active Expired
- 1982-03-04 EP EP82101706A patent/EP0059948B1/en not_active Expired
- 1982-03-04 AT AT82101706T patent/ATE16489T1/de active
- 1982-03-04 DK DK095482A patent/DK168627B1/da not_active IP Right Cessation
- 1982-03-04 IE IE491/82A patent/IE52387B1/en not_active IP Right Cessation
- 1982-03-04 KR KR8200933A patent/KR890000765B1/ko not_active Expired
- 1982-03-04 NO NO820686A patent/NO157175C/no unknown
-
1983
- 1983-01-25 ES ES519254A patent/ES519254A0/es active Granted
-
1986
- 1986-08-21 HK HK616/86A patent/HK61686A/xx not_active IP Right Cessation
- 1986-12-30 MY MY700/86A patent/MY8600700A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES8402827A1 (es) | 1984-03-01 |
| ES510087A0 (es) | 1983-04-16 |
| MY8600700A (en) | 1986-12-31 |
| PH18345A (en) | 1985-06-05 |
| NO157175B (no) | 1987-10-26 |
| GB2096600B (en) | 1985-06-05 |
| DK95482A (da) | 1982-09-06 |
| GR76518B (enExample) | 1984-08-10 |
| EP0059948B1 (en) | 1985-11-13 |
| KR890000765B1 (ko) | 1989-04-05 |
| GB2096600A (en) | 1982-10-20 |
| ES519254A0 (es) | 1984-03-01 |
| AU8103782A (en) | 1982-09-09 |
| ATE16489T1 (de) | 1985-11-15 |
| IE52387B1 (en) | 1987-10-14 |
| IE820491L (en) | 1982-09-05 |
| NO157175C (no) | 1988-02-03 |
| KR830009046A (ko) | 1983-12-17 |
| AU557590B2 (en) | 1986-12-24 |
| DE3267352D1 (en) | 1985-12-19 |
| IL65137A0 (en) | 1982-05-31 |
| IL65137A (en) | 1987-02-27 |
| HK61686A (en) | 1986-08-29 |
| NZ199885A (en) | 1985-04-30 |
| CA1190550A (en) | 1985-07-16 |
| EP0059948A1 (en) | 1982-09-15 |
| US4405628A (en) | 1983-09-20 |
| DK168627B1 (da) | 1994-05-09 |
| NO820686L (no) | 1982-09-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20020304 |