ES8304983A1 - "un procedimiento para la preparacion de pirrolo(3,4-d)(2)benzacepinas". - Google Patents
"un procedimiento para la preparacion de pirrolo(3,4-d)(2)benzacepinas".Info
- Publication number
- ES8304983A1 ES8304983A1 ES513620A ES513620A ES8304983A1 ES 8304983 A1 ES8304983 A1 ES 8304983A1 ES 513620 A ES513620 A ES 513620A ES 513620 A ES513620 A ES 513620A ES 8304983 A1 ES8304983 A1 ES 8304983A1
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- alkynyl
- alkenyl
- alkyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
- C07C45/305—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation with halogenochromate reagents, e.g. pyridinium chlorochromate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/68—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings containing halogen
- C07C63/72—Polycyclic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE PIRROLO 3,4-D 2 / BENZACEPINAS Y DE SUS SALES DE ADICION DE ACIDO FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE A, R , R , R , R Y R PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE SUSTITUCION EN LA POSICION 2 DE UN COMPUESTO DE FORMULA (II), EN LA QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), CON UN ALQUILO INFERIOR, ALQUELINO C <- ; ALQUILINO C <- , HIDROXIALQUILO C <- O GRUPO -CO-O-ALQUILO INFERIOR. LA REACCION SE LLEVA A CABO EN PRESENCIA DE UNA BASE FUERTE EN CANTIDADES EQUIVALENTES, A UNA TEMPERATURA ENTRE -78 C Y 0 C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES SEDANTES Y ANXIOLITICOS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17555580A | 1980-08-05 | 1980-08-05 | |
US06/286,124 US4354973A (en) | 1980-08-05 | 1981-07-23 | Pyrrolo[3,4-d][2]benzazepines |
Publications (2)
Publication Number | Publication Date |
---|---|
ES513620A0 ES513620A0 (es) | 1983-04-01 |
ES8304983A1 true ES8304983A1 (es) | 1983-04-01 |
Family
ID=26871324
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES504525A Expired ES8300765A1 (es) | 1980-08-05 | 1981-08-04 | Un procedimiento para la preparacion de pirrolo (3,4-d)(2) benzacepinas |
ES513622A Granted ES513622A0 (es) | 1980-08-05 | 1982-07-01 | "un procedimiento para la preparacion de pirrolo (3,4-d) (2)-benzacepinas". |
ES513621A Granted ES513621A0 (es) | 1980-08-05 | 1982-07-01 | "un procedimiento para la preparacion de pirrolo(3,4-d)(2)benzacepinas". |
ES513620A Expired ES8304983A1 (es) | 1980-08-05 | 1982-07-01 | "un procedimiento para la preparacion de pirrolo(3,4-d)(2)benzacepinas". |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES504525A Expired ES8300765A1 (es) | 1980-08-05 | 1981-08-04 | Un procedimiento para la preparacion de pirrolo (3,4-d)(2) benzacepinas |
ES513622A Granted ES513622A0 (es) | 1980-08-05 | 1982-07-01 | "un procedimiento para la preparacion de pirrolo (3,4-d) (2)-benzacepinas". |
ES513621A Granted ES513621A0 (es) | 1980-08-05 | 1982-07-01 | "un procedimiento para la preparacion de pirrolo(3,4-d)(2)benzacepinas". |
Country Status (25)
Country | Link |
---|---|
US (1) | US4354973A (es) |
EP (1) | EP0045519B1 (es) |
AR (1) | AR230639A1 (es) |
AT (1) | ATE13888T1 (es) |
AU (1) | AU545298B2 (es) |
CA (1) | CA1174674A (es) |
CH (1) | CH648849A5 (es) |
DE (2) | DE3131064A1 (es) |
DK (1) | DK347681A (es) |
ES (4) | ES8300765A1 (es) |
FI (1) | FI71149C (es) |
FR (1) | FR2488257A1 (es) |
GB (1) | GB2083460B (es) |
HU (1) | HU188071B (es) |
IE (1) | IE51466B1 (es) |
IL (1) | IL63487A (es) |
IT (1) | IT1138133B (es) |
LU (1) | LU83531A1 (es) |
MC (1) | MC1409A1 (es) |
NL (1) | NL8103655A (es) |
NO (1) | NO812647L (es) |
NZ (1) | NZ197920A (es) |
PH (1) | PH16814A (es) |
PT (1) | PT73481B (es) |
SE (1) | SE8104659L (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL68711A (en) * | 1982-05-18 | 1986-12-31 | Sparamedica Ag | Dihydro-8-halo-6-phenylpyrrolo-(3,4-d)(2)benzazepin derivatives,their preparation and pharmaceutical compositions containing them |
US4436662A (en) | 1982-06-28 | 1984-03-13 | Hoffmann-La Roche Inc. | Pyrrolo[3,4-d][2]benzazepinones |
US5098901A (en) * | 1991-09-10 | 1992-03-24 | Sterling Drug Inc. | Imidazo [1,2-b][2]benzazepine and pyrimido [1,2-b][2]benzazepine antiarrhythmic agents |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3523947A (en) * | 1966-11-23 | 1970-08-11 | Hoffmann La Roche | 1-cyclic amidine-5-aryl-1,4-benzodiazepine and process |
US4022801A (en) * | 1974-06-03 | 1977-05-10 | Ciba-Geigy Corporation | Pyrazolobenzazepines |
US3947585A (en) * | 1974-06-03 | 1976-03-30 | Ciba-Geigy Corporation | Pyrazolobenzazepines |
US4169150A (en) * | 1975-11-12 | 1979-09-25 | Teijin Limited | Benzodiazepine derivatives and pharmaceutical compositions containing said derivatives |
-
1981
- 1981-07-23 US US06/286,124 patent/US4354973A/en not_active Expired - Fee Related
- 1981-07-27 CH CH4869/81A patent/CH648849A5/de not_active IP Right Cessation
- 1981-08-03 NL NL8103655A patent/NL8103655A/nl not_active Application Discontinuation
- 1981-08-03 HU HU812247A patent/HU188071B/hu unknown
- 1981-08-03 LU LU83531A patent/LU83531A1/de unknown
- 1981-08-03 SE SE8104659A patent/SE8104659L/xx unknown
- 1981-08-03 IT IT23347/81A patent/IT1138133B/it active
- 1981-08-03 IL IL63487A patent/IL63487A/xx unknown
- 1981-08-03 NZ NZ197920A patent/NZ197920A/en unknown
- 1981-08-04 NO NO812647A patent/NO812647L/no unknown
- 1981-08-04 PH PH26000A patent/PH16814A/en unknown
- 1981-08-04 MC MC811533A patent/MC1409A1/xx unknown
- 1981-08-04 FI FI812416A patent/FI71149C/fi not_active IP Right Cessation
- 1981-08-04 DK DK347681A patent/DK347681A/da not_active Application Discontinuation
- 1981-08-04 PT PT73481A patent/PT73481B/pt unknown
- 1981-08-04 CA CA000383108A patent/CA1174674A/en not_active Expired
- 1981-08-04 FR FR8115107A patent/FR2488257A1/fr active Granted
- 1981-08-04 ES ES504525A patent/ES8300765A1/es not_active Expired
- 1981-08-04 GB GB8123763A patent/GB2083460B/en not_active Expired
- 1981-08-05 DE DE19813131064 patent/DE3131064A1/de not_active Withdrawn
- 1981-08-05 AU AU73825/81A patent/AU545298B2/en not_active Ceased
- 1981-08-05 AR AR286350A patent/AR230639A1/es active
- 1981-08-05 AT AT81106137T patent/ATE13888T1/de not_active IP Right Cessation
- 1981-08-05 EP EP81106137A patent/EP0045519B1/de not_active Expired
- 1981-08-05 DE DE8181106137T patent/DE3171021D1/de not_active Expired
- 1981-08-14 IE IE1775/81A patent/IE51466B1/en unknown
-
1982
- 1982-07-01 ES ES513622A patent/ES513622A0/es active Granted
- 1982-07-01 ES ES513621A patent/ES513621A0/es active Granted
- 1982-07-01 ES ES513620A patent/ES8304983A1/es not_active Expired
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