BG103861A - 6,7-disubstituted-4-aminopyrido[2,3-d]pyrimidine compounds - Google Patents
6,7-disubstituted-4-aminopyrido[2,3-d]pyrimidine compoundsInfo
- Publication number
- BG103861A BG103861A BG103861A BG10386199A BG103861A BG 103861 A BG103861 A BG 103861A BG 103861 A BG103861 A BG 103861A BG 10386199 A BG10386199 A BG 10386199A BG 103861 A BG103861 A BG 103861A
- Authority
- BG
- Bulgaria
- Prior art keywords
- aminopyrido
- disubstituted
- compounds
- pyrimidine compounds
- therapeutically effective
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The compounds have the formula where R1, R2, R3 & R4 are variants and are selected from the groups including alkyl, aryl, heteoraryl and heterocycle and their substituted variants. The invention also relates to a method for the adenosinekinase inhibition by the applications including a therapeutically effective quantity of them in combination with a pharmaceutically acceptable carrier. The invention also relates to a method for the treatment of cerebral ischaemia, epilepsy, pain, inflammation and sepsis in mammals where therapeutically effective quantity of the compounds is applied, and to methods for their preparation. 18 claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83439397A | 1997-04-16 | 1997-04-16 | |
PCT/US1998/004127 WO1998046603A1 (en) | 1997-04-16 | 1998-04-16 | 6,7-disubstituted-4-aminopyrido[2,3-d]pyrimidine compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
BG103861A true BG103861A (en) | 2000-06-30 |
Family
ID=25266829
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG103861A BG103861A (en) | 1997-04-16 | 1999-11-05 | 6,7-disubstituted-4-aminopyrido[2,3-d]pyrimidine compounds |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0979230A1 (en) |
JP (1) | JP2001520649A (en) |
KR (1) | KR20010006453A (en) |
CN (1) | CN1259948A (en) |
AR (1) | AR012435A1 (en) |
AU (1) | AU744528B2 (en) |
BG (1) | BG103861A (en) |
BR (1) | BR9809088A (en) |
CA (1) | CA2287465A1 (en) |
CO (1) | CO4940439A1 (en) |
HU (1) | HUP0001402A3 (en) |
IL (1) | IL131892A0 (en) |
NO (1) | NO995033L (en) |
NZ (1) | NZ337844A (en) |
PL (1) | PL336262A1 (en) |
SK (1) | SK142099A3 (en) |
TR (1) | TR199902456T2 (en) |
TW (1) | TW458977B (en) |
WO (1) | WO1998046603A1 (en) |
ZA (1) | ZA982912B (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001057040A1 (en) * | 2000-02-03 | 2001-08-09 | Abbott Laboratories | 6,7-disubstituted-4-aminopyrido[2,3-d]pyrimidine compounds |
KR100639772B1 (en) * | 2001-02-12 | 2006-10-30 | 에프. 호프만-라 로슈 아게 | 6-substituted pyrido-pyrimidines |
US20090209492A1 (en) | 2004-11-12 | 2009-08-20 | Trustees Of Tufts College | Lipase Inhibitors |
EP2139332A4 (en) * | 2007-03-28 | 2010-04-21 | Merck Sharp & Dohme | Substituted pyrido[2,3-d]pyrimidine derivatives as cannabinoid-1 receptor modulators |
SG11201502527UA (en) * | 2012-10-05 | 2015-04-29 | Rigel Pharmaceuticals Inc | Gdf-8 inhibitors |
US10016432B2 (en) | 2016-05-27 | 2018-07-10 | Legacy Emanuel Hospital & Health Center | Methanocarba derivatives of pseudoribose that inhibit adenosine kinase |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB774094A (en) * | 1953-01-02 | 1957-05-08 | Wellcome Found | Improvements in or relating to pyrimidine compounds |
IL112249A (en) * | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
-
1998
- 1998-03-27 TW TW087104674A patent/TW458977B/en not_active IP Right Cessation
- 1998-04-06 ZA ZA982912A patent/ZA982912B/en unknown
- 1998-04-14 CO CO98020309A patent/CO4940439A1/en unknown
- 1998-04-15 AR ARP980101732A patent/AR012435A1/en unknown
- 1998-04-16 CN CN98806072A patent/CN1259948A/en active Pending
- 1998-04-16 WO PCT/US1998/004127 patent/WO1998046603A1/en not_active Application Discontinuation
- 1998-04-16 BR BR9809088-7A patent/BR9809088A/en not_active IP Right Cessation
- 1998-04-16 PL PL98336262A patent/PL336262A1/en unknown
- 1998-04-16 CA CA002287465A patent/CA2287465A1/en not_active Abandoned
- 1998-04-16 AU AU70981/98A patent/AU744528B2/en not_active Ceased
- 1998-04-16 IL IL13189298A patent/IL131892A0/en unknown
- 1998-04-16 EP EP98917950A patent/EP0979230A1/en not_active Withdrawn
- 1998-04-16 HU HU0001402A patent/HUP0001402A3/en unknown
- 1998-04-16 TR TR1999/02456T patent/TR199902456T2/en unknown
- 1998-04-16 KR KR1019997009543A patent/KR20010006453A/en not_active Application Discontinuation
- 1998-04-16 NZ NZ337844A patent/NZ337844A/en unknown
- 1998-04-16 JP JP54387898A patent/JP2001520649A/en active Pending
- 1998-04-16 SK SK1420-99A patent/SK142099A3/en unknown
-
1999
- 1999-10-15 NO NO995033A patent/NO995033L/en not_active Application Discontinuation
- 1999-11-05 BG BG103861A patent/BG103861A/en unknown
Also Published As
Publication number | Publication date |
---|---|
HUP0001402A2 (en) | 2000-10-28 |
PL336262A1 (en) | 2000-06-19 |
SK142099A3 (en) | 2000-05-16 |
CA2287465A1 (en) | 1998-10-22 |
CO4940439A1 (en) | 2000-07-24 |
TW458977B (en) | 2001-10-11 |
NZ337844A (en) | 2001-11-30 |
AR012435A1 (en) | 2000-10-18 |
KR20010006453A (en) | 2001-01-26 |
AU744528B2 (en) | 2002-02-28 |
JP2001520649A (en) | 2001-10-30 |
BR9809088A (en) | 2000-08-01 |
AU7098198A (en) | 1998-11-11 |
EP0979230A1 (en) | 2000-02-16 |
CN1259948A (en) | 2000-07-12 |
NO995033L (en) | 1999-12-15 |
NO995033D0 (en) | 1999-10-15 |
HUP0001402A3 (en) | 2001-01-29 |
WO1998046603A1 (en) | 1998-10-22 |
TR199902456T2 (en) | 2000-07-21 |
IL131892A0 (en) | 2001-03-19 |
ZA982912B (en) | 1998-10-09 |
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