HUP0001402A2 - 6,7-disubstituted-4-aminopyrido[2,3-d] pyrimidine compounds, pharmaceutical compositions thereof and process for their preparation - Google Patents
6,7-disubstituted-4-aminopyrido[2,3-d] pyrimidine compounds, pharmaceutical compositions thereof and process for their preparationInfo
- Publication number
- HUP0001402A2 HUP0001402A2 HU0001402A HUP0001402A HUP0001402A2 HU P0001402 A2 HUP0001402 A2 HU P0001402A2 HU 0001402 A HU0001402 A HU 0001402A HU P0001402 A HUP0001402 A HU P0001402A HU P0001402 A2 HUP0001402 A2 HU P0001402A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- short
- aminopyrido
- disubstituted
- pyrimidine compounds
- Prior art date
Links
- -1 6,7-disubstituted-4-aminopyrido[2,3-d] pyrimidine compounds Chemical class 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- OOXNYFKPOPJIOT-UHFFFAOYSA-N 5-(3-bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-amine;dihydrochloride Chemical compound Cl.Cl.C=12C(N)=NC=NC2=NC(C=2C=NC(=CC=2)N2CCOCC2)=CC=1C1=CC=CC(Br)=C1 OOXNYFKPOPJIOT-UHFFFAOYSA-N 0.000 abstract 1
- 108010076278 Adenosine kinase Proteins 0.000 abstract 1
- 102100032534 Adenosine kinase Human genes 0.000 abstract 1
- 201000006474 Brain Ischemia Diseases 0.000 abstract 1
- 206010008120 Cerebral ischaemia Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 206010040047 Sepsis Diseases 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 206010008118 cerebral infarction Diseases 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 230000036407 pain Effects 0.000 abstract 1
- 230000037324 pain perception Effects 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A találmány tárgya az (I) általános képletű 6,7-diszubsztituált-4-aminopirido[2,3-d]pirimidin-vegyületek -, a képletben R1 és R2 jelentése egymástól függetlenül hidrogénatom, rövid szénláncúalkilcsoport, arilalkilcsoport vagy acilcsoport, vagy a hozzájukkapcsolódó nitrogénatommal együtt 5-7 tagú gyűrűt alkotnak, amelyadott esetben O, N és S közül választott 1-3 további heteroatomottartalmaz, R3 és R4 jelentése egymástól függetlenül rövid szénláncú alkilcsoport,rövid szénláncú alkenilcsoport, rövid szénláncú alkinilcsoport,arilcsoport, arilalkilcsoport, heteroarilcsoport vagy heterociklusoscsoport, és a szaggatott vonal adott esetben jelenlévő kettős kötéstjelent -, amelyek adenozin-kináz gátló aktivitásuk következtében főlegagyi ischémia, epilepszia, fájdalomérzékelés, fájdalom, gyulladás éssepsis elleni gyógyászati készítmények előállítására alkalmazhatók. ÓThe subject of the invention is the 6,7-disubstituted-4-aminopyrido[2,3-d]pyrimidine compounds of the general formula (I), in which R1 and R2 are independently a hydrogen atom, a lower alkyl group, an arylalkyl group or an acyl group, or the related together with a nitrogen atom, they form a 5-7 membered ring, which in any case contains 1-3 additional heteroatoms selected from O, N and S, R3 and R4 are independently a short-chain alkyl group, a short-carbon alkenyl group, a short-chain alkynyl group, an aryl group, an arylalkyl group, a heteroaryl group or a heterocyclic group, and the dashed line means the double bond that may be present - which, due to their adenosine kinase inhibitory activity, can be used mainly for the production of medicinal preparations against cerebral ischemia, epilepsy, pain perception, pain, inflammation and sepsis. HE
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83439397A | 1997-04-16 | 1997-04-16 | |
| PCT/US1998/004127 WO1998046603A1 (en) | 1997-04-16 | 1998-04-16 | 6,7-disubstituted-4-aminopyrido[2,3-d]pyrimidine compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0001402A2 true HUP0001402A2 (en) | 2000-10-28 |
| HUP0001402A3 HUP0001402A3 (en) | 2001-01-29 |
Family
ID=25266829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0001402A HUP0001402A3 (en) | 1997-04-16 | 1998-04-16 | 6,7-disubstituted-4-aminopyrido[2,3-d] pyrimidine compounds, pharmaceutical compositions thereof and process for their preparation |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0979230A1 (en) |
| JP (1) | JP2001520649A (en) |
| KR (1) | KR20010006453A (en) |
| CN (1) | CN1259948A (en) |
| AR (1) | AR012435A1 (en) |
| AU (1) | AU744528B2 (en) |
| BG (1) | BG103861A (en) |
| BR (1) | BR9809088A (en) |
| CA (1) | CA2287465A1 (en) |
| CO (1) | CO4940439A1 (en) |
| HU (1) | HUP0001402A3 (en) |
| IL (1) | IL131892A0 (en) |
| NO (1) | NO995033L (en) |
| NZ (1) | NZ337844A (en) |
| PL (1) | PL336262A1 (en) |
| SK (1) | SK142099A3 (en) |
| TR (1) | TR199902456T2 (en) |
| TW (1) | TW458977B (en) |
| WO (1) | WO1998046603A1 (en) |
| ZA (1) | ZA982912B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001057040A1 (en) * | 2000-02-03 | 2001-08-09 | Abbott Laboratories | 6,7-disubstituted-4-aminopyrido[2,3-d]pyrimidine compounds |
| BRPI0207172B8 (en) * | 2001-02-12 | 2021-05-25 | Hoffmann La Roche | 6-substituted pyrido-pyrimidines, their composition and use, as well as their intermediate |
| EP1824861A2 (en) | 2004-11-12 | 2007-08-29 | Trustees of the Tufts College | Lipase inhibitors |
| WO2008121257A1 (en) * | 2007-03-28 | 2008-10-09 | Merck & Co., Inc. | Substituted pyrido[2,3-d]pyrimidine derivatives as cannabinoid-1 receptor modulators |
| EA201590693A1 (en) * | 2012-10-05 | 2015-08-31 | Ригель Фармасьютикалс, Инк. | INHIBITORS GDF-8 |
| WO2017205848A1 (en) * | 2016-05-27 | 2017-11-30 | Legacy Emanuel Hospital & Health Center | Methanocarba derivatives of pseudoribose that inhibit adenosine kinase |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB774094A (en) * | 1953-01-02 | 1957-05-08 | Wellcome Found | Improvements in or relating to pyrimidine compounds |
| IL112249A (en) * | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
-
1998
- 1998-03-27 TW TW087104674A patent/TW458977B/en not_active IP Right Cessation
- 1998-04-06 ZA ZA982912A patent/ZA982912B/en unknown
- 1998-04-14 CO CO98020309A patent/CO4940439A1/en unknown
- 1998-04-15 AR ARP980101732A patent/AR012435A1/en unknown
- 1998-04-16 HU HU0001402A patent/HUP0001402A3/en unknown
- 1998-04-16 BR BR9809088-7A patent/BR9809088A/en not_active IP Right Cessation
- 1998-04-16 IL IL13189298A patent/IL131892A0/en unknown
- 1998-04-16 CN CN98806072A patent/CN1259948A/en active Pending
- 1998-04-16 AU AU70981/98A patent/AU744528B2/en not_active Ceased
- 1998-04-16 TR TR1999/02456T patent/TR199902456T2/en unknown
- 1998-04-16 WO PCT/US1998/004127 patent/WO1998046603A1/en not_active Application Discontinuation
- 1998-04-16 JP JP54387898A patent/JP2001520649A/en active Pending
- 1998-04-16 CA CA002287465A patent/CA2287465A1/en not_active Abandoned
- 1998-04-16 NZ NZ337844A patent/NZ337844A/en unknown
- 1998-04-16 SK SK1420-99A patent/SK142099A3/en unknown
- 1998-04-16 EP EP98917950A patent/EP0979230A1/en not_active Withdrawn
- 1998-04-16 KR KR1019997009543A patent/KR20010006453A/en not_active Application Discontinuation
- 1998-04-16 PL PL98336262A patent/PL336262A1/en unknown
-
1999
- 1999-10-15 NO NO995033A patent/NO995033L/en not_active Application Discontinuation
- 1999-11-05 BG BG103861A patent/BG103861A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TR199902456T2 (en) | 2000-07-21 |
| NO995033L (en) | 1999-12-15 |
| KR20010006453A (en) | 2001-01-26 |
| WO1998046603A1 (en) | 1998-10-22 |
| BG103861A (en) | 2000-06-30 |
| ZA982912B (en) | 1998-10-09 |
| PL336262A1 (en) | 2000-06-19 |
| TW458977B (en) | 2001-10-11 |
| CN1259948A (en) | 2000-07-12 |
| CO4940439A1 (en) | 2000-07-24 |
| EP0979230A1 (en) | 2000-02-16 |
| NZ337844A (en) | 2001-11-30 |
| HUP0001402A3 (en) | 2001-01-29 |
| AU7098198A (en) | 1998-11-11 |
| AU744528B2 (en) | 2002-02-28 |
| CA2287465A1 (en) | 1998-10-22 |
| NO995033D0 (en) | 1999-10-15 |
| SK142099A3 (en) | 2000-05-16 |
| JP2001520649A (en) | 2001-10-30 |
| BR9809088A (en) | 2000-08-01 |
| IL131892A0 (en) | 2001-03-19 |
| AR012435A1 (en) | 2000-10-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0100348A2 (en) | Bicycles containing a six menbered ring with one or two nitrogen atoms, process for their preparation, use of them, pharmaceutical compositions containing the same and intermediates | |
| HUP0303108A2 (en) | Substituted pyrazoles and pharmaceutical compositions containing them | |
| HUP0300641A2 (en) | Triazaspiro[5.5]undecane derivatives and pharmaceutical compositions containing the same as the active ingredient | |
| HUP0204083A2 (en) | 2-amino-nicotinamide derivatives and their use as vegf-receptor tyrosine kinase inhibitors, process for their preparation and pharmaceutical compositions containing them | |
| HUP0003309A2 (en) | Imidazolyl-cyclic acetals, process for producing them and pharmaceutical compositions containing the same | |
| HUP0402336A2 (en) | Thieno[2,3-d]pyrimidine-2,4-dione derivatives, process for their preparation, their use in the modulation of autoimmune disease and pharmaceutical compositions containing them | |
| UA66825C2 (en) | Azapolycyclic compounds condensed with aryl | |
| HUP0001507A2 (en) | Pyrrolo [2,3-d] pyrimidine derivatives, process for their preparation, their use and pharmaceutical compositions containing them | |
| HUP0300082A2 (en) | 7- and 9-carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline derivatives, process for their preparation and use and pharmaceutical compositions containing them | |
| HUP0303350A2 (en) | Use of substituted imidazo[1,2-a]pyridine-, imidazo[1,2-a]pyrimidine and imidazo[1,2-a]pyrazine-3-yl-amine derivatives for producing nos-inhibiting pharmaceutical compositions | |
| HUP0301195A2 (en) | Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists and pharmaceutical compositions containing the compounds | |
| HUP0203450A2 (en) | Pyrazolo '4,3-d! pyrimidine derivatives, process for their preparation and pharmaceutical compositions containing them and their use | |
| HUP0103542A2 (en) | 4,4-biarylpiperidine derivatives with opioid receptor activity and pharmaceutical compositions containing them | |
| HK1068334A1 (en) | Derivatives of triazolyl-imidazopyridine and of the triazolylpurines useful as ligands of the adenosine a2a receptor and their use as medicaments | |
| HUP0401083A2 (en) | 4-amino-6-phenyl-pyrrolo [2,3-d] pyrimidine derivatives, pharmaceutical compositions containing them and process for the preparation of the compounds | |
| HUP9802200A2 (en) | Rapamycin derivatives, process for their preparation, pharmaceutical compositions containing them and their use | |
| HUP9802323A2 (en) | Pyrimidine derivatives , process for producing them and pharmaceutical compositions containing them | |
| HUP0301625A2 (en) | 1,3,4-oxadiazine-compounds as inhibitors of copper-containing amine oxidases, process for their preparation and their use for preparation of pharmaceutical compositions | |
| HUP0204246A2 (en) | Novel thiazolo[4,5-d]pyrimidine compounds, process for their preparation, pharmaceutical compositions containing them and their use | |
| HUP0004628A1 (en) | Novel camptothecin tetracyclic analogues, preparation methods and pharmaceutical compositions containing them | |
| HUP0100328A2 (en) | Novel triazolo(4,5-d)pyrimidine compounds, and pharmaceutical compositions containing the compounds | |
| HUP0100558A2 (en) | S-oxide and s,s,-dioxide tetrahydrothiopyran phenyloxazolidinones, their use for preparation of pharmaceutical compositions and process for determining the inhibitory activity of compounds to human monoamino oxidase | |
| HUP0001434A2 (en) | 5,7-disubstituted 4-aminopyrido[2,3-d]pyrimidine compounds, pharmaceutical compouads thereof and process for their preparation | |
| HUP0101498A1 (en) | Use of dexmedetomidine for producing pharmaceutical compositions with sedative effect | |
| HUP0301587A2 (en) | 5-aminoalkyl-pyrazolo[4,3-d]pyrimidines with a phosphodiesterase v-inhibiting effect, pharmaceutical compositions containing them and processes for their preparations |