BG103842A - 5,7-disubstituted 4-aminopyrido [2,3-d]pyrimidine compounds and their application as adenosinekinase inhibitors - Google Patents
5,7-disubstituted 4-aminopyrido [2,3-d]pyrimidine compounds and their application as adenosinekinase inhibitorsInfo
- Publication number
- BG103842A BG103842A BG103842A BG10384299A BG103842A BG 103842 A BG103842 A BG 103842A BG 103842 A BG103842 A BG 103842A BG 10384299 A BG10384299 A BG 10384299A BG 103842 A BG103842 A BG 103842A
- Authority
- BG
- Bulgaria
- Prior art keywords
- alkyl
- heteroaryl
- aryl
- compound
- heterocyclic group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The method of adenosinekinase inhibition includes the application of a compound with the formula where R1 & R2, separately, are selected from H, lower alkyl, C1-C6 alkoxyC1-C6 alkyl, arylC1-C6 alkyl, -C(O)C1-C6 alkyl, -C(O)aryl, -C(O)heterocyclyl, or can be bound together with the nitrogen to which they are attached forming 5-7-member ring optionally containing 1-2 additional heteoratoms selected from O, N or S, R3 is of the group including lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heterocyclic group, heteroarylalkyl or heterocycloalkyl where the heteroaryl or the heterocyclic group are directly or indirectly bound by a ring carbon atom, R4 is from the group including lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heterocyclic group, heteroarylalkyl or heteorcycloalkyl, and the pinctured line --- means optional presence of a double bond provided that the suitable valencies are preserved. The invention also relates to a pharmaceutical composition containing therapeutically effective quantity of the compound in a combination with a pharmaceutically acceptable carrier, to a method for the treatment of cerebral ischaemia, epilepsy, pain killing, inflammation and sepsis in mammals where therapeutically effective quantity of the compound is administered, and to a method for the preparation of the above compounds and compounds with formula I. 19 claims
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83821697A | 1997-04-16 | 1997-04-16 | |
| PCT/US1998/007207 WO1998046605A1 (en) | 1997-04-16 | 1998-04-14 | 5,7-disubstituted 4-aminopyrido[2,3-d]pyrimidine compounds and their use as adenosine kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG103842A true BG103842A (en) | 2000-06-30 |
Family
ID=25276561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG103842A Pending BG103842A (en) | 1997-04-16 | 1999-10-29 | 5,7-disubstituted 4-aminopyrido [2,3-d]pyrimidine compounds and their application as adenosinekinase inhibitors |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0989986A1 (en) |
| JP (1) | JP2001520655A (en) |
| KR (1) | KR20010006509A (en) |
| CN (1) | CN1252070A (en) |
| AR (1) | AR012436A1 (en) |
| AU (1) | AU7108398A (en) |
| BG (1) | BG103842A (en) |
| BR (1) | BR9809055A (en) |
| CA (1) | CA2286909A1 (en) |
| CO (1) | CO4940446A1 (en) |
| HU (1) | HUP0001434A3 (en) |
| IL (1) | IL131618A0 (en) |
| NO (1) | NO995036D0 (en) |
| PL (1) | PL336304A1 (en) |
| SK (1) | SK141799A3 (en) |
| TR (1) | TR199902455T2 (en) |
| WO (1) | WO1998046605A1 (en) |
| ZA (1) | ZA983177B (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000023444A1 (en) * | 1998-10-21 | 2000-04-27 | Abbott Laboratories | 5,7-disubstituted-4-aminopyrido[2,3-d]pyrimidine compounds |
| WO2002064594A2 (en) | 2001-02-12 | 2002-08-22 | F. Hoffmann-La Roche Ag | 6-substituted pyrido-pyrimidines |
| MXPA04006882A (en) | 2002-01-17 | 2004-12-06 | Neurogen Corp | Substituted quinazolin-4-ylamine analogues as modulators of capsaicin. |
| DE10335183A1 (en) * | 2003-07-30 | 2005-02-24 | Bayer Cropscience Ag | Fungicidal drug combinations |
| ATE449097T1 (en) * | 2005-07-21 | 2009-12-15 | Hoffmann La Roche | PYRIDOÄ2,3-DÜPYRIMIDINE-2,4-DIAMINE COMPOUNDS AS PTPIB INHIBITORS |
| US7910595B2 (en) * | 2005-12-21 | 2011-03-22 | Abbott Laboratories | Anti-viral compounds |
| EP1971611B1 (en) | 2005-12-21 | 2012-10-10 | Abbott Laboratories | Anti-viral compounds |
| WO2008133753A2 (en) | 2006-12-20 | 2008-11-06 | Abbott Laboratories | Anti-viral compounds |
| MX2010002258A (en) * | 2007-08-27 | 2010-04-22 | Helicon Therapeutics Inc | Therapeutic isoxazole compounds. |
| CA2694401C (en) | 2007-08-31 | 2012-12-04 | Eisai R&D Management Co., Ltd. | Polycyclic compound |
| DE102007061764A1 (en) * | 2007-12-20 | 2009-06-25 | Bayer Healthcare Ag | Anellated cyanopyridines and their use |
| MX2011008501A (en) * | 2009-02-26 | 2011-09-01 | Eisai R&D Man Co Ltd | Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors. |
| US9550750B2 (en) | 2012-10-05 | 2017-01-24 | Merck Sharp & Dohme Corp. | Indoline compounds as aldosterone synthase inhibitors |
| US9822122B2 (en) | 2016-03-31 | 2017-11-21 | Oncternal Therapeutics, Inc. | Indoline analogs and uses thereof |
| CN110256420B (en) * | 2019-05-07 | 2020-04-28 | 江西中医药大学 | Tetrahydropyridopyrimidine derivatives, their preparation and use |
| CN110283171A (en) * | 2019-07-17 | 2019-09-27 | 鼎泰(南京)临床医学研究有限公司 | Compound of the one kind containing Pyridopyrimidine -4- amine structure, pharmaceutical composition and its application |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5324731A (en) * | 1989-02-14 | 1994-06-28 | Amira, Inc. | Method of inhibiting transformation of cells in which purine metabolic enzyme activity is elevated |
| IL112249A (en) * | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| US6143749A (en) * | 1995-06-07 | 2000-11-07 | Abbott Laboratories | Heterocyclic substituted cyclopentane compounds |
-
1998
- 1998-04-14 AU AU71083/98A patent/AU7108398A/en not_active Abandoned
- 1998-04-14 BR BR9809055-0A patent/BR9809055A/en not_active Application Discontinuation
- 1998-04-14 KR KR1019997009599A patent/KR20010006509A/en not_active Application Discontinuation
- 1998-04-14 SK SK1417-99A patent/SK141799A3/en unknown
- 1998-04-14 EP EP98918093A patent/EP0989986A1/en not_active Withdrawn
- 1998-04-14 TR TR1999/02455T patent/TR199902455T2/en unknown
- 1998-04-14 IL IL13161898A patent/IL131618A0/en unknown
- 1998-04-14 WO PCT/US1998/007207 patent/WO1998046605A1/en not_active Application Discontinuation
- 1998-04-14 CA CA002286909A patent/CA2286909A1/en not_active Abandoned
- 1998-04-14 HU HU0001434A patent/HUP0001434A3/en unknown
- 1998-04-14 CN CN98804151A patent/CN1252070A/en active Pending
- 1998-04-14 PL PL98336304A patent/PL336304A1/en unknown
- 1998-04-14 JP JP54408898A patent/JP2001520655A/en active Pending
- 1998-04-15 AR ARP980101733A patent/AR012436A1/en unknown
- 1998-04-15 ZA ZA983177A patent/ZA983177B/en unknown
- 1998-04-16 CO CO98020979A patent/CO4940446A1/en unknown
-
1999
- 1999-10-15 NO NO995036A patent/NO995036D0/en not_active Application Discontinuation
- 1999-10-29 BG BG103842A patent/BG103842A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ZA983177B (en) | 1999-01-22 |
| EP0989986A1 (en) | 2000-04-05 |
| CA2286909A1 (en) | 1998-10-22 |
| CN1252070A (en) | 2000-05-03 |
| HUP0001434A3 (en) | 2001-01-29 |
| IL131618A0 (en) | 2001-01-28 |
| TR199902455T2 (en) | 2000-01-21 |
| PL336304A1 (en) | 2000-06-19 |
| AR012436A1 (en) | 2000-10-18 |
| NO995036L (en) | 1999-10-15 |
| CO4940446A1 (en) | 2000-07-24 |
| BR9809055A (en) | 2000-08-08 |
| JP2001520655A (en) | 2001-10-30 |
| AU7108398A (en) | 1998-11-11 |
| KR20010006509A (en) | 2001-01-26 |
| SK141799A3 (en) | 2000-08-14 |
| HUP0001434A2 (en) | 2000-10-28 |
| WO1998046605A1 (en) | 1998-10-22 |
| NO995036D0 (en) | 1999-10-15 |
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