BR9809055A - 5,7-disubstituted 4-amino-pyrido (2,3-d) pyrimidine compounds and their use as adenosinokinase inhibitors - Google Patents
5,7-disubstituted 4-amino-pyrido (2,3-d) pyrimidine compounds and their use as adenosinokinase inhibitorsInfo
- Publication number
- BR9809055A BR9809055A BR9809055-0A BR9809055A BR9809055A BR 9809055 A BR9809055 A BR 9809055A BR 9809055 A BR9809055 A BR 9809055A BR 9809055 A BR9809055 A BR 9809055A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- aryl
- heteroaryl
- heterocyclic
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
"COMPOSTOS DE 4-AMINO--PIRIDO[2,3-d]PIRIMIDINA 5,7-DISSUBSTITUìDA E SEU USO COMO INIBIDORES DE ADENOSINOCINASE" Método para inibir adenosinocinase administrando um composto que tem a fórmula (I) onde R^ 1^ e R^ 2^ são independentemente selecionados entre H, alquila inferior, alcóxi (C~ 1~-C~ 6~)-alquila (C~ 1~-C~ 6~), aril-alquila (C~ 1~-C~ 6~), -C(O)-alquila (C~ 1~-C~ 6~), -C(O)-arila, -C(O)-heterocíclico, ou podem unir-se ao nitrogênio ao qual eles estão anexados, para formar um anel de 5 a 7 membros, contendo opcionalmente 1 a 2 heteroátomos adicionais, selecionados entre O, N ou S; R^ 3^ é selecionado em grupo consistindo de alquila inferior, alquenila inferior, alquinila inferior, ciclo-alquila, arila, aril-alquila, heteroarila, grupo heterocíclico, heteroaril-alquila ou heterociclo-alquila, em que os grupos heteroarila e heterocíclico estão ligados diretamente ou indiretamente por um carbono anelar; R^ 4^ é selecionado em grupo consistindo de alquila inferior, alquenila inferior, alquinila inferior, ciclo-alquila, arila, aril-alquila, heteroarila, grupo heterocíclico, heteroaril-alquila ou heterociclo-alquila; e uma linha tracejada - - - indica que uma dupla ligação está opcionalmente presente, desde que as valências apropriadas sejam mantidas, uma composição farmacêutica que compreende uma quantidade terapeuticamente eficaz de um desses compostos acima em combinação com um excipiente de uso farmacêutico, e um método para tratar isquemia cerebral, epilepsia, nicipercepção, inflamação e sepse em um mamífero que necessite desse tratamento, que compreende administrar ao mamífero uma quantidade terapeuticamente eficaz de um composto desses, um processo para preparar esses compostos, e compostos que têm a fórmula acima na qual R^ 1^, R^ 2^, R^ 3^ e R^ 4^ são definidos separadamente."4-AMINO COMPOUNDS - PIRID [2,3-d] PYRIMIDIN 5,7-DISSUBSTITUED AND THEIR USE AS ADENOSINOCINASE INHIBITORS" Method to inhibit adenosinokinase by administering a compound that has the formula (I) where R ^ 1 ^ e R ^ 2 ^ are independently selected from H, lower alkyl, (C ~ 1 ~ -C ~ 6 ~) -alkyl (C ~ 1 ~ -C ~ 6 ~), aryl-alkyl (C ~ 1 ~ -C ~ 6 ~), -C (O) -alkyl (C ~ 1 ~ -C ~ 6 ~), -C (O) -aryl, -C (O) -heterocyclic, or they can bond with the nitrogen to which they are attached, to form a 5- to 7-membered ring, optionally containing 1 to 2 additional heteroatoms, selected from O, N or S; R ^ 3 ^ is selected from the group consisting of lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, aryl, aryl-alkyl, heteroaryl, heterocyclic group, heteroaryl-alkyl or heterocycle-alkyl, in which the heteroaryl and heterocyclic groups are linked directly or indirectly by an annular carbon; R 4 is selected from the group consisting of lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, aryl, aryl-alkyl, heteroaryl, heterocyclic, heteroaryl-alkyl or heterocyclo-alkyl; and a dotted line - - - indicates that a double bond is optionally present, provided that the appropriate valencies are maintained, a pharmaceutical composition comprising a therapeutically effective amount of one of these compounds above in combination with a pharmaceutical excipient, and a method to treat cerebral ischemia, epilepsy, niciperception, inflammation and sepsis in a mammal in need of such treatment, which comprises administering to the mammal a therapeutically effective amount of such a compound, a process for preparing those compounds, and compounds having the above formula in which R ^ 1 ^, R ^ 2 ^, R ^ 3 ^ and R ^ 4 ^ are defined separately.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83821697A | 1997-04-16 | 1997-04-16 | |
| PCT/US1998/007207 WO1998046605A1 (en) | 1997-04-16 | 1998-04-14 | 5,7-disubstituted 4-aminopyrido[2,3-d]pyrimidine compounds and their use as adenosine kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9809055A true BR9809055A (en) | 2000-08-08 |
Family
ID=25276561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9809055-0A BR9809055A (en) | 1997-04-16 | 1998-04-14 | 5,7-disubstituted 4-amino-pyrido (2,3-d) pyrimidine compounds and their use as adenosinokinase inhibitors |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0989986A1 (en) |
| JP (1) | JP2001520655A (en) |
| KR (1) | KR20010006509A (en) |
| CN (1) | CN1252070A (en) |
| AR (1) | AR012436A1 (en) |
| AU (1) | AU7108398A (en) |
| BG (1) | BG103842A (en) |
| BR (1) | BR9809055A (en) |
| CA (1) | CA2286909A1 (en) |
| CO (1) | CO4940446A1 (en) |
| HU (1) | HUP0001434A3 (en) |
| IL (1) | IL131618A0 (en) |
| NO (1) | NO995036L (en) |
| PL (1) | PL336304A1 (en) |
| SK (1) | SK141799A3 (en) |
| TR (1) | TR199902455T2 (en) |
| WO (1) | WO1998046605A1 (en) |
| ZA (1) | ZA983177B (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000023444A1 (en) * | 1998-10-21 | 2000-04-27 | Abbott Laboratories | 5,7-disubstituted-4-aminopyrido[2,3-d]pyrimidine compounds |
| IL156872A0 (en) | 2001-02-12 | 2004-02-08 | Hoffmann La Roche | 6-substituted pyrido-pyrimidines |
| MXPA04006882A (en) | 2002-01-17 | 2004-12-06 | Neurogen Corp | Substituted quinazolin-4-ylamine analogues as modulators of capsaicin. |
| DE10335183A1 (en) * | 2003-07-30 | 2005-02-24 | Bayer Cropscience Ag | Fungicidal drug combinations |
| ATE449097T1 (en) * | 2005-07-21 | 2009-12-15 | Hoffmann La Roche | PYRIDOÄ2,3-DÜPYRIMIDINE-2,4-DIAMINE COMPOUNDS AS PTPIB INHIBITORS |
| AU2006330924B2 (en) * | 2005-12-21 | 2012-03-15 | Abbvie Inc. | Anti-viral compounds |
| ES2395386T3 (en) | 2005-12-21 | 2013-02-12 | Abbott Laboratories | Antiviral compounds |
| EP2094276A4 (en) | 2006-12-20 | 2011-01-05 | Abbott Lab | Anti-viral compounds |
| MX2010002258A (en) | 2007-08-27 | 2010-04-22 | Helicon Therapeutics Inc | Therapeutic isoxazole compounds. |
| EP2559693B1 (en) | 2007-08-31 | 2014-11-26 | Eisai R&D Management Co., Ltd. | Polycyclic compound |
| DE102007061764A1 (en) * | 2007-12-20 | 2009-06-25 | Bayer Healthcare Ag | Anellated cyanopyridines and their use |
| WO2010098487A1 (en) * | 2009-02-26 | 2010-09-02 | Eisai R&D Management Co., Ltd. | Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors |
| WO2014055595A1 (en) | 2012-10-05 | 2014-04-10 | Merck Sharp & Dohme Corp. | Indoline compounds as aldosterone synthase inhibitiors related applications |
| KR102514814B1 (en) | 2016-03-31 | 2023-03-27 | 온크터널 테라퓨틱스, 인코포레이티드. | Indoline analogs and uses thereof |
| CN110256420B (en) * | 2019-05-07 | 2020-04-28 | 江西中医药大学 | Tetrahydropyridopyrimidine derivatives, their preparation and use |
| CN110283171A (en) * | 2019-07-17 | 2019-09-27 | 鼎泰(南京)临床医学研究有限公司 | Compound of the one kind containing Pyridopyrimidine -4- amine structure, pharmaceutical composition and its application |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5324731A (en) * | 1989-02-14 | 1994-06-28 | Amira, Inc. | Method of inhibiting transformation of cells in which purine metabolic enzyme activity is elevated |
| IL112249A (en) * | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| US6143749A (en) * | 1995-06-07 | 2000-11-07 | Abbott Laboratories | Heterocyclic substituted cyclopentane compounds |
-
1998
- 1998-04-14 BR BR9809055-0A patent/BR9809055A/en not_active Application Discontinuation
- 1998-04-14 SK SK1417-99A patent/SK141799A3/en unknown
- 1998-04-14 HU HU0001434A patent/HUP0001434A3/en unknown
- 1998-04-14 EP EP98918093A patent/EP0989986A1/en not_active Withdrawn
- 1998-04-14 AU AU71083/98A patent/AU7108398A/en not_active Abandoned
- 1998-04-14 CA CA002286909A patent/CA2286909A1/en not_active Abandoned
- 1998-04-14 TR TR1999/02455T patent/TR199902455T2/en unknown
- 1998-04-14 CN CN98804151A patent/CN1252070A/en active Pending
- 1998-04-14 IL IL13161898A patent/IL131618A0/en unknown
- 1998-04-14 KR KR1019997009599A patent/KR20010006509A/en not_active Application Discontinuation
- 1998-04-14 PL PL98336304A patent/PL336304A1/en unknown
- 1998-04-14 WO PCT/US1998/007207 patent/WO1998046605A1/en not_active Application Discontinuation
- 1998-04-14 JP JP54408898A patent/JP2001520655A/en active Pending
- 1998-04-15 AR ARP980101733A patent/AR012436A1/en unknown
- 1998-04-15 ZA ZA983177A patent/ZA983177B/en unknown
- 1998-04-16 CO CO98020979A patent/CO4940446A1/en unknown
-
1999
- 1999-10-15 NO NO995036A patent/NO995036L/en not_active Application Discontinuation
- 1999-10-29 BG BG103842A patent/BG103842A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001520655A (en) | 2001-10-30 |
| HUP0001434A2 (en) | 2000-10-28 |
| NO995036D0 (en) | 1999-10-15 |
| WO1998046605A1 (en) | 1998-10-22 |
| CO4940446A1 (en) | 2000-07-24 |
| BG103842A (en) | 2000-06-30 |
| ZA983177B (en) | 1999-01-22 |
| EP0989986A1 (en) | 2000-04-05 |
| CA2286909A1 (en) | 1998-10-22 |
| AU7108398A (en) | 1998-11-11 |
| TR199902455T2 (en) | 2000-01-21 |
| CN1252070A (en) | 2000-05-03 |
| IL131618A0 (en) | 2001-01-28 |
| AR012436A1 (en) | 2000-10-18 |
| SK141799A3 (en) | 2000-08-14 |
| PL336304A1 (en) | 2000-06-19 |
| NO995036L (en) | 1999-10-15 |
| KR20010006509A (en) | 2001-01-26 |
| HUP0001434A3 (en) | 2001-01-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |