CO4940446A1 - COMPOUNDS 4-AMINOPIRIDE [2,3-D] PIRIMIDINE 5,7-DISSTITUTED - Google Patents
COMPOUNDS 4-AMINOPIRIDE [2,3-D] PIRIMIDINE 5,7-DISSTITUTEDInfo
- Publication number
- CO4940446A1 CO4940446A1 CO98020979A CO98020979A CO4940446A1 CO 4940446 A1 CO4940446 A1 CO 4940446A1 CO 98020979 A CO98020979 A CO 98020979A CO 98020979 A CO98020979 A CO 98020979A CO 4940446 A1 CO4940446 A1 CO 4940446A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- aryl
- group
- heterocyclic
- heteroaryl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
Un compuesto que tiene la fórmula: en donde R1 y R2 son independientemente seleccionados entre H, alquil inferior, alcoxi C1 -C6 -alquil C1 -C6 , aril-alquil C1 -C6 , -C(O)-alquil C1 -C6 , -C(O)-aril, -C(O)-heterocíclico, o pueden unirse junto con el nitrógeno al cual van ligados para formar un anillo de 5-7 miembros que contiene opcionalmente 1 - 2 heteroátomos adicionales seleccionados entre O, N, ó S; R3 se selecciona del grupo conformado por alquil inferior, alquenil inferior, alquinil inferior, cicloalquil, aril, arilalquil, heteroaril, grupo heterocíclico, heteroarilalquil o heterocicloalquil en donde los grupos heteroaril y heterocíclico van ligados directamente o indirectamente a través de un carbono del anillo; R4 se selecciona del grupo conformado por alquil inferior, alquenil inferior, alquinil inferior, cicloalquil, aril, arilalquil, heteroaril, grupo heterocíclico, heteroarilalquil o heterocicloalquil; en donde la línea entrecortada --- indica que opcionalmente está presente un doble enlace a condición de que se mantengan las valencias apropiadas, in vitro o a un mamífero.A compound having the formula: wherein R1 and R2 are independently selected from H, lower alkyl, C1-C6-alkoxy-C1-C6-alkyl, aryl-C1-C6-alkyl, -C (O) -C1-C6-alkyl, - C (O) -aryl, -C (O) -heterocyclic, or can bind together with the nitrogen to which they are attached to form a 5-7 membered ring optionally containing 1-2 additional heteroatoms selected from O, N, or S; R3 is selected from the group consisting of lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heterocyclic, heteroarylalkyl or heterocycloalkyl group where the heteroaryl and heterocyclic groups are linked directly or indirectly through a ring carbon; R4 is selected from the group consisting of lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heterocyclic group, heteroarylalkyl or heterocycloalkyl; wherein the broken line --- indicates that a double bond is optionally present provided that the appropriate valences are maintained, in vitro or to a mammal.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83821697A | 1997-04-16 | 1997-04-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4940446A1 true CO4940446A1 (en) | 2000-07-24 |
Family
ID=25276561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO98020979A CO4940446A1 (en) | 1997-04-16 | 1998-04-16 | COMPOUNDS 4-AMINOPIRIDE [2,3-D] PIRIMIDINE 5,7-DISSTITUTED |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0989986A1 (en) |
| JP (1) | JP2001520655A (en) |
| KR (1) | KR20010006509A (en) |
| CN (1) | CN1252070A (en) |
| AR (1) | AR012436A1 (en) |
| AU (1) | AU7108398A (en) |
| BG (1) | BG103842A (en) |
| BR (1) | BR9809055A (en) |
| CA (1) | CA2286909A1 (en) |
| CO (1) | CO4940446A1 (en) |
| HU (1) | HUP0001434A3 (en) |
| IL (1) | IL131618A0 (en) |
| NO (1) | NO995036D0 (en) |
| PL (1) | PL336304A1 (en) |
| SK (1) | SK141799A3 (en) |
| TR (1) | TR199902455T2 (en) |
| WO (1) | WO1998046605A1 (en) |
| ZA (1) | ZA983177B (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000023444A1 (en) * | 1998-10-21 | 2000-04-27 | Abbott Laboratories | 5,7-disubstituted-4-aminopyrido[2,3-d]pyrimidine compounds |
| BRPI0207172B8 (en) | 2001-02-12 | 2021-05-25 | Hoffmann La Roche | 6-substituted pyrido-pyrimidines, their composition and use, as well as their intermediate |
| JP2005526714A (en) | 2002-01-17 | 2005-09-08 | ニューロジェン・コーポレーション | Substituted quinazolin-4-ylamine analogs as modulators of capsaicin |
| DE10335183A1 (en) * | 2003-07-30 | 2005-02-24 | Bayer Cropscience Ag | Fungicidal drug combinations |
| ATE449097T1 (en) * | 2005-07-21 | 2009-12-15 | Hoffmann La Roche | PYRIDOÄ2,3-DÜPYRIMIDINE-2,4-DIAMINE COMPOUNDS AS PTPIB INHIBITORS |
| RU2441869C2 (en) * | 2005-12-21 | 2012-02-10 | Эбботт Лэборетриз | Antiviral compouds |
| WO2007081517A2 (en) | 2005-12-21 | 2007-07-19 | Abbott Laboratories | Anti-viral compounds |
| WO2008133753A2 (en) | 2006-12-20 | 2008-11-06 | Abbott Laboratories | Anti-viral compounds |
| ES2748599T3 (en) * | 2007-08-27 | 2020-03-17 | Dart Neuroscience Cayman Ltd | Isoxazole therapeutic compounds |
| JP5433418B2 (en) | 2007-08-31 | 2014-03-05 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Polycyclic compound |
| DE102007061764A1 (en) * | 2007-12-20 | 2009-06-25 | Bayer Healthcare Ag | Anellated cyanopyridines and their use |
| CA2753696A1 (en) * | 2009-02-26 | 2010-09-02 | Noritaka Kitazawa | Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors |
| WO2014055595A1 (en) | 2012-10-05 | 2014-04-10 | Merck Sharp & Dohme Corp. | Indoline compounds as aldosterone synthase inhibitiors related applications |
| KR102375929B1 (en) | 2016-03-31 | 2022-03-16 | 온크터널 테라퓨틱스, 인코포레이티드. | Indoline analogs and uses thereof |
| CN110256420B (en) * | 2019-05-07 | 2020-04-28 | 江西中医药大学 | Tetrahydropyridopyrimidine derivatives, their preparation and use |
| CN110283171A (en) * | 2019-07-17 | 2019-09-27 | 鼎泰(南京)临床医学研究有限公司 | Compound of the one kind containing Pyridopyrimidine -4- amine structure, pharmaceutical composition and its application |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5324731A (en) * | 1989-02-14 | 1994-06-28 | Amira, Inc. | Method of inhibiting transformation of cells in which purine metabolic enzyme activity is elevated |
| IL112249A (en) * | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| US6143749A (en) * | 1995-06-07 | 2000-11-07 | Abbott Laboratories | Heterocyclic substituted cyclopentane compounds |
-
1998
- 1998-04-14 CA CA002286909A patent/CA2286909A1/en not_active Abandoned
- 1998-04-14 EP EP98918093A patent/EP0989986A1/en not_active Withdrawn
- 1998-04-14 WO PCT/US1998/007207 patent/WO1998046605A1/en not_active Application Discontinuation
- 1998-04-14 SK SK1417-99A patent/SK141799A3/en unknown
- 1998-04-14 AU AU71083/98A patent/AU7108398A/en not_active Abandoned
- 1998-04-14 CN CN98804151A patent/CN1252070A/en active Pending
- 1998-04-14 TR TR1999/02455T patent/TR199902455T2/en unknown
- 1998-04-14 JP JP54408898A patent/JP2001520655A/en active Pending
- 1998-04-14 HU HU0001434A patent/HUP0001434A3/en unknown
- 1998-04-14 BR BR9809055-0A patent/BR9809055A/en not_active Application Discontinuation
- 1998-04-14 PL PL98336304A patent/PL336304A1/en unknown
- 1998-04-14 IL IL13161898A patent/IL131618A0/en unknown
- 1998-04-14 KR KR1019997009599A patent/KR20010006509A/en not_active Application Discontinuation
- 1998-04-15 AR ARP980101733A patent/AR012436A1/en unknown
- 1998-04-15 ZA ZA983177A patent/ZA983177B/en unknown
- 1998-04-16 CO CO98020979A patent/CO4940446A1/en unknown
-
1999
- 1999-10-15 NO NO995036A patent/NO995036D0/en not_active Application Discontinuation
- 1999-10-29 BG BG103842A patent/BG103842A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0001434A2 (en) | 2000-10-28 |
| NO995036L (en) | 1999-10-15 |
| BR9809055A (en) | 2000-08-08 |
| NO995036D0 (en) | 1999-10-15 |
| CA2286909A1 (en) | 1998-10-22 |
| JP2001520655A (en) | 2001-10-30 |
| TR199902455T2 (en) | 2000-01-21 |
| BG103842A (en) | 2000-06-30 |
| ZA983177B (en) | 1999-01-22 |
| EP0989986A1 (en) | 2000-04-05 |
| IL131618A0 (en) | 2001-01-28 |
| AR012436A1 (en) | 2000-10-18 |
| SK141799A3 (en) | 2000-08-14 |
| HUP0001434A3 (en) | 2001-01-29 |
| KR20010006509A (en) | 2001-01-26 |
| PL336304A1 (en) | 2000-06-19 |
| WO1998046605A1 (en) | 1998-10-22 |
| AU7108398A (en) | 1998-11-11 |
| CN1252070A (en) | 2000-05-03 |
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