ES8303430A1 - Un procedimiento para la preparacion de un derivado de cefa-losporina - Google Patents
Un procedimiento para la preparacion de un derivado de cefa-losporinaInfo
- Publication number
- ES8303430A1 ES8303430A1 ES506532A ES506532A ES8303430A1 ES 8303430 A1 ES8303430 A1 ES 8303430A1 ES 506532 A ES506532 A ES 506532A ES 506532 A ES506532 A ES 506532A ES 8303430 A1 ES8303430 A1 ES 8303430A1
- Authority
- ES
- Spain
- Prior art keywords
- compound
- formulai
- lower alkyl
- acid
- acyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930186147 Cephalosporin Natural products 0.000 title 1
- 229940124587 cephalosporin Drugs 0.000 title 1
- 150000001780 cephalosporins Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- -1 1H-tetrazol-5-yl Chemical group 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- UCKZMPLVLCKKMO-LHLIQPBNSA-N cephamycin Chemical group S1CC(C)=C(C(O)=O)N2C(=O)[C@@H](C)[C@]21OC UCKZMPLVLCKKMO-LHLIQPBNSA-N 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000008282 halocarbons Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/57—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE CEFALOSPORINA, DE FORMULA (I), DONDE R REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO (ALCOXI INFERIOR)METILO O (ALCOXI INFERIOR)CARBONILALCOXIMETILO, R REPRESENTA UN GRUPO 1H-TETRAZOL-5-ILO,1,3,4-TIADIAZOL-2-ILO, Y R REPRESENTA UN GRUPO ACILO, Y SUS SALES FARMACOLOGICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II), DONDE R REPRESENTA UN GRUPO ACILAMIDO, ALCOXICARBONILAMIDO O FTALIMIDO; R >A REPRESENTA UN GRUPO (ALCOXI INFERIOR)METILO O ARALQUILOXIMETILO; Y R TIENE EL SIGNIFICADO YA INDICADO, CON UN COMPUESTO DE FORMULA R -X, DONDE R TIENE EL SIGNIFICADO YA INDICADO Y X REPRESENTA UN ATOMO DE HALOGENO, EN PRESENCIA DE UN COMPUESTO DE FORMULA (III), DONDE R REPRESENTA UN GRUPO ALQUILO INFERIOR. DE APLICACION EN LA PREPARACION DE ANTIBIOTICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55149112A JPS5772986A (en) | 1980-10-24 | 1980-10-24 | Production of cephalosporin derviative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8303430A1 true ES8303430A1 (es) | 1983-02-01 |
| ES506532A0 ES506532A0 (es) | 1983-02-01 |
Family
ID=15467965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES506532A Granted ES506532A0 (es) | 1980-10-24 | 1981-10-23 | Un procedimiento para la preparacion de un derivado de cefa-losporina |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS5772986A (es) |
| CA (1) | CA1155835A (es) |
| CH (1) | CH649088A5 (es) |
| ES (1) | ES506532A0 (es) |
| FI (1) | FI72122C (es) |
| IT (1) | IT1144849B (es) |
| NL (1) | NL8104831A (es) |
-
1980
- 1980-10-24 JP JP55149112A patent/JPS5772986A/ja active Granted
-
1981
- 1981-10-23 CA CA000388592A patent/CA1155835A/en not_active Expired
- 1981-10-23 FI FI813320A patent/FI72122C/fi not_active IP Right Cessation
- 1981-10-23 ES ES506532A patent/ES506532A0/es active Granted
- 1981-10-23 IT IT68386/81A patent/IT1144849B/it active
- 1981-10-23 CH CH6792/81A patent/CH649088A5/de not_active IP Right Cessation
- 1981-10-26 NL NL8104831A patent/NL8104831A/nl not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IT1144849B (it) | 1986-10-29 |
| FI72122B (fi) | 1986-12-31 |
| CH649088A5 (en) | 1985-04-30 |
| ES506532A0 (es) | 1983-02-01 |
| FI72122C (fi) | 1987-04-13 |
| JPH0157116B2 (es) | 1989-12-04 |
| IT8168386A0 (it) | 1981-10-23 |
| NL8104831A (nl) | 1982-05-17 |
| CA1155835A (en) | 1983-10-25 |
| FI813320L (fi) | 1982-04-25 |
| JPS5772986A (en) | 1982-05-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19971001 |