JPS5645484A - C-15003pho and its preparation - Google Patents
C-15003pho and its preparationInfo
- Publication number
- JPS5645484A JPS5645484A JP12221679A JP12221679A JPS5645484A JP S5645484 A JPS5645484 A JP S5645484A JP 12221679 A JP12221679 A JP 12221679A JP 12221679 A JP12221679 A JP 12221679A JP S5645484 A JPS5645484 A JP S5645484A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- carbon atoms
- less carbon
- alkanoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
NEW MATERIAL:Maytansinoid compounds of formula I (when R1 is hydroxyl and R2 is H, R3 is H, alkzaoyl of 5 or less carbon atoms except the group of formula II; when R1 is H and R2 is hyroxyl, R3 is H, alkznoyl of 5 or less carbon atoms). EXAMPLE:C-15003epi-PHO-0. USE:Antibacterial, antiprotozoal, antitumorigenic or synthetic intermediate thereof. PREPARATION:A compound of formula III (R'3 is H, alkanoyl of 5 or less carbon atoms) is brought into contact with the culture medium of a specific microorganism or its treated product to produce a compound of formula IV. As the microorganism, is used, e.g., Streptomyces sclerotialus IFO-12246 or the like. Another process is the deacylation of a compound of formula V (R''3 is alkanoyl of 5 or less carbon atoms) to give a compound of formula VI.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12221679A JPS5645484A (en) | 1979-09-21 | 1979-09-21 | C-15003pho and its preparation |
| EP80105163A EP0028683A1 (en) | 1979-09-21 | 1980-08-29 | Antibiotic C-15003 PHO and production thereof |
| US06/188,238 US4364866A (en) | 1979-09-21 | 1980-09-17 | Maytansinoids |
| CA000360469A CA1146887A (en) | 1979-09-21 | 1980-09-18 | Antibiotic c-15003 pho and production thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12221679A JPS5645484A (en) | 1979-09-21 | 1979-09-21 | C-15003pho and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5645484A true JPS5645484A (en) | 1981-04-25 |
| JPS6361951B2 JPS6361951B2 (en) | 1988-11-30 |
Family
ID=14830421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP12221679A Granted JPS5645484A (en) | 1979-09-21 | 1979-09-21 | C-15003pho and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5645484A (en) |
-
1979
- 1979-09-21 JP JP12221679A patent/JPS5645484A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6361951B2 (en) | 1988-11-30 |
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