ES8303090A1 - Procedimiento para la obtencion de comprimidos medicionales de rapida disgregacion. - Google Patents

Procedimiento para la obtencion de comprimidos medicionales de rapida disgregacion.

Info

Publication number
ES8303090A1
ES8303090A1 ES506981A ES506981A ES8303090A1 ES 8303090 A1 ES8303090 A1 ES 8303090A1 ES 506981 A ES506981 A ES 506981A ES 506981 A ES506981 A ES 506981A ES 8303090 A1 ES8303090 A1 ES 8303090A1
Authority
ES
Spain
Prior art keywords
pharmaceutical active
disaggregating
fast
pharmaceutical tablet
disintegrating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES506981A
Other languages
English (en)
Other versions
ES506981A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES506981A0 publication Critical patent/ES506981A0/es
Publication of ES8303090A1 publication Critical patent/ES8303090A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPRIMIDOS MEDICINALES DE RAPIDA DISGREGACION, QUE CONTIENEN EL MEDICAMENTO EN FORMA GRANULADA CON CESION RETARDADA DE LA SUSTANCIA ACTIVA. COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE INTRODUCE EL PRODUCTO ACTIVO MEDICINAL CRISTALINO O GRANULADO EN UN APARATO DE ROCIADO EN LECHO FLUIDIFICADO O EN UN RECIPIENTE DE GRAGEADO; SEGUNDA, DICHO PRODUCTO ACTIVO MEDICINAL SE RECUBRE POR ROCIADO CON UNA MEZCLA HOMOGENEA, DISPERSADA EN AGUA, FORMADA POR UN ESTER DEL ACIDO POLIACRILICO INSOLUBLE EN AGUA PERO DISPERSABLE EN ELLA Y POR UN ESTER DE CELULOSA INSOLUBLE EN AGUA PERO DISPERSABLE EN ELLA; Y POR ULTIMO, SE COMPRIME EL PRODUCTO ACTIVO MEDICINAL EN FORMA GRANULADA CON UN AGENTE DE DISGREGACION QUE TENGA PROPIEDADES AGLUTINANTES.
ES506981A 1980-11-12 1981-11-10 Procedimiento para la obtencion de comprimidos medicionales de rapida disgregacion. Expired ES8303090A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH839380 1980-11-12

Publications (2)

Publication Number Publication Date
ES506981A0 ES506981A0 (es) 1983-02-01
ES8303090A1 true ES8303090A1 (es) 1983-02-01

Family

ID=4339640

Family Applications (1)

Application Number Title Priority Date Filing Date
ES506981A Expired ES8303090A1 (es) 1980-11-12 1981-11-10 Procedimiento para la obtencion de comprimidos medicionales de rapida disgregacion.

Country Status (20)

Country Link
EP (1) EP0052076B1 (es)
JP (1) JPS57109715A (es)
AT (1) ATE13486T1 (es)
AU (1) AU552861B2 (es)
CA (1) CA1178202A (es)
CY (1) CY1429A (es)
DE (1) DE3170764D1 (es)
DK (1) DK154537C (es)
ES (1) ES8303090A1 (es)
FI (1) FI76254C (es)
GB (1) GB2086725B (es)
GR (1) GR76337B (es)
HK (1) HK53388A (es)
IE (1) IE51827B1 (es)
IL (1) IL64255A0 (es)
MY (1) MY8700132A (es)
NO (1) NO157964C (es)
NZ (1) NZ198937A (es)
PT (1) PT73963B (es)
ZA (1) ZA817795B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3314003A1 (de) * 1983-04-18 1984-10-18 Boehringer Ingelheim KG, 6507 Ingelheim Teilbare tablette mit verzoegerter wirkstofffreigabe und verfahren zu deren herstellung
CH658188A5 (de) * 1984-03-23 1986-10-31 Ciba Geigy Ag Lagerstabile schnellzerfallende pharmazeutische presslinge.
JPS6144811A (ja) * 1984-08-10 1986-03-04 Ss Pharmaceut Co Ltd 徐放性ジクロフエナクナトリウム製剤
ES8801121A1 (es) * 1985-02-19 1988-01-01 Key Pharma Procedimiento de fabricacion de una unidad de dosificacion para la administracion oral de cloruro potasico.
JPS61210025A (ja) * 1985-03-14 1986-09-18 Teisan Seiyaku Kk 安定化された抗生物質複合顆粒製剤
EP0272265B1 (de) * 1985-09-25 1991-05-22 Gergely, Gerhard, Dr. Zerfallstablette und verfahren zu ihrer herstellung
EP0301006B1 (en) * 1986-04-01 1992-05-06 The Upjohn Company Methylprednisolone/sodium carboxymethyl starch tablet composition
GB8628359D0 (en) * 1986-11-27 1986-12-31 Zyma Sa Galenical formulation
GB8702411D0 (en) * 1987-02-03 1987-03-11 Zyma Sa Swellable pellets
GB8707421D0 (en) * 1987-03-27 1987-04-29 Wellcome Found Pharmaceutical formulations
GB8707416D0 (en) * 1987-03-27 1987-04-29 Wellcome Found Pharmaceutical formulations
GB8724763D0 (en) * 1987-10-22 1987-11-25 Aps Research Ltd Sustained-release formulations
CH675537A5 (es) * 1988-03-25 1990-10-15 Ciba Geigy Ag
JPH0273011A (ja) * 1988-07-28 1990-03-13 Warner Lambert Co 医薬投与剤型製造用のセルロースおよびアクリル系重合体の水性重合体分散体およびその投与剤型
JP2514078B2 (ja) * 1988-08-22 1996-07-10 エスエス製薬株式会社 圧縮成型製剤
KR100190254B1 (ko) * 1991-01-30 1999-06-01 레슬리 에드워즈 수-분산성 정제
US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
US5698226A (en) * 1993-07-13 1997-12-16 Glaxo Wellcome Inc. Water-dispersible tablets
US6245351B1 (en) 1996-03-07 2001-06-12 Takeda Chemical Industries, Ltd. Controlled-release composition
FR2766089B1 (fr) * 1997-07-21 2000-06-02 Prographarm Lab Comprime multiparticulaire perfectionne a delitement rapide
KR100882156B1 (ko) * 2003-08-08 2009-02-06 아지노모토 가부시키가이샤 나테글리니드 함유 제제
JP5122380B2 (ja) * 2008-06-16 2013-01-16 エーザイ・アール・アンド・ディー・マネジメント株式会社 薬物の放出を制御した速崩錠及びその製法
EP2253306A1 (en) * 2009-05-18 2010-11-24 Royal College of Surgeons in Ireland Orodispersible dosage forms containing solid drug dispersions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2336218C3 (de) * 1973-07-17 1985-11-14 Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz Orale Arzneiform
US4143129A (en) * 1975-10-11 1979-03-06 Lilly Industries Limited Cephalexin tablets
GB1560475A (en) * 1975-10-11 1980-02-06 Lilly Industries Ltd Pharmaceutical formulation
US4140756A (en) * 1976-06-10 1979-02-20 Mead Johnson & Company Film-coated matrix core tablet

Also Published As

Publication number Publication date
FI76254C (fi) 1988-10-10
AU7738281A (en) 1982-05-20
NO813826L (no) 1982-05-13
NO157964C (no) 1988-06-29
NZ198937A (en) 1985-04-30
DK499181A (da) 1982-05-13
PT73963A (de) 1981-12-01
IL64255A0 (en) 1982-02-28
GR76337B (es) 1984-08-04
ES506981A0 (es) 1983-02-01
IE812643L (en) 1982-05-12
GB2086725A (en) 1982-05-19
JPS57109715A (en) 1982-07-08
HK53388A (en) 1988-07-22
IE51827B1 (en) 1987-04-01
AU552861B2 (en) 1986-06-26
NO157964B (no) 1988-03-14
DK154537B (da) 1988-11-28
JPH0228564B2 (es) 1990-06-25
CA1178202A (en) 1984-11-20
DK154537C (da) 1989-04-17
MY8700132A (en) 1987-12-31
PT73963B (de) 1983-11-23
EP0052076A1 (de) 1982-05-19
DE3170764D1 (en) 1985-07-04
GB2086725B (en) 1985-08-21
ZA817795B (en) 1982-10-27
CY1429A (en) 1988-09-02
EP0052076B1 (de) 1985-05-29
ATE13486T1 (de) 1985-06-15
FI76254B (fi) 1988-06-30
FI813532L (fi) 1982-05-13

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970606